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Scavenger receptor class B member 1

Summary

UniProt ID: O18824
Gene Symbol: SCARB1
Gene ID: 282346
Organism: Bos taurus (domestic cattle)

External Links

PubChem: O18824
Re-Glyco: O18824

Annotation

Keyword: Cell membrane Disulfide bond Glycoprotein Receptor Reference proteome Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 29 in total

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GO Term	Evidence Code	Reference
endothelial cell proliferation
cholesterol catabolic process
positive regulation of nitric oxide mediated signal transduction
positive regulation of triglyceride biosynthetic process	IEA	GO_REF
positive regulation of cholesterol storage	IEA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

lipoprotein particle mediated signaling [inference]

high density lipoprotein particle mediated signaling

cell recognition [inference]

phagocytosis, recognition [inference]

recognition of apoptotic cell

metabolic process [inference]

catabolic process [inference]

lipid catabolic process [inference]

steroid catabolic process [inference]

sterol catabolic process [inference]

cholesterol catabolic process

small molecule catabolic process [inference]

alcohol catabolic process [inference]

cholesterol catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid catabolic process [inference]

sterol catabolic process [inference]

cholesterol catabolic process

sterol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol catabolic process

sterol catabolic process [inference]

cholesterol catabolic process

lipid catabolic process [inference]

steroid catabolic process [inference]

sterol catabolic process [inference]

cholesterol catabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

alcohol catabolic process [inference]

cholesterol catabolic process

secondary alcohol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol catabolic process

small molecule catabolic process [inference]

alcohol catabolic process [inference]

cholesterol catabolic process

cell population proliferation [inference]

epithelial cell proliferation [inference]

endothelial cell proliferation

cell motility [inference]

cell migration [inference]

endothelial cell migration [inference]

blood vessel endothelial cell migration

transmembrane transport [inference]

vitamin transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-containing complex remodeling [inference]

protein-lipid complex remodeling [inference]

plasma lipoprotein particle remodeling [inference]

high-density lipoprotein particle remodeling

protein-lipid complex organization [inference]

protein-lipid complex remodeling [inference]

plasma lipoprotein particle remodeling [inference]

high-density lipoprotein particle remodeling

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle remodeling [inference]

high-density lipoprotein particle remodeling

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

vasodilation

digestive system process [inference]

intestinal absorption [inference]

intestinal lipid absorption

plasma lipoprotein particle clearance

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle remodeling [inference]

high-density lipoprotein particle remodeling

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis [inference]

acylglycerol homeostasis [inference]

triglyceride homeostasis

sterol homeostasis [inference]

cholesterol homeostasis

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

adhesion of symbiont to host

response to stimulus [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

detection of molecule of bacterial origin [inference]

detection of lipopolysaccharide

response to lipopolysaccharide [inference]

detection of lipopolysaccharide

detection of external biotic stimulus [inference]

detection of molecule of bacterial origin [inference]

detection of lipopolysaccharide

response to biotic stimulus [inference]

detection of biotic stimulus [inference]

detection of external biotic stimulus [inference]

detection of molecule of bacterial origin [inference]

detection of lipopolysaccharide

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

detection of molecule of bacterial origin [inference]

detection of lipopolysaccharide

response to lipopolysaccharide [inference]

detection of lipopolysaccharide

detection of external biotic stimulus [inference]

detection of molecule of bacterial origin [inference]

detection of lipopolysaccharide

response to chemical [inference]

response to lipid [inference]

response to lipopolysaccharide [inference]

detection of lipopolysaccharide

response to oxygen-containing compound [inference]

response to lipopolysaccharide [inference]

detection of lipopolysaccharide

detection of stimulus [inference]

detection of chemical stimulus [inference]

detection of molecule of bacterial origin [inference]

detection of lipopolysaccharide

detection of biotic stimulus [inference]

detection of external biotic stimulus [inference]

detection of molecule of bacterial origin [inference]

detection of lipopolysaccharide

localization [inference]

establishment of localization [inference]

transport [inference]

lipid transport [inference]

phospholipid transport

sterol transport [inference]

cholesterol transport [inference]

lipopolysaccharide transport

organophosphate ester transport [inference]

phospholipid transport

organic hydroxy compound transport [inference]

sterol transport [inference]

cholesterol transport [inference]

vitamin transport [inference]

vitamin transmembrane transport

transmembrane transport [inference]

vitamin transmembrane transport

carbohydrate derivative transport [inference]

lipopolysaccharide transport

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of sphingolipid mediated signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

regulation of sphingolipid mediated signaling pathway [inference]

positive regulation of sphingolipid mediated signaling pathway

regulation of intracellular signal transduction [inference]

regulation of nitric oxide mediated signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of sphingolipid mediated signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

regulation of localization [inference]

regulation of lipid localization [inference]

positive regulation of lipid localization [inference]

positive regulation of lipid storage [inference]

positive regulation of cholesterol storage

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of sphingolipid mediated signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of sphingolipid mediated signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

positive regulation of lipid storage [inference]

positive regulation of cholesterol storage

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of sphingolipid mediated signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

positive regulation of lipid localization [inference]

positive regulation of lipid storage [inference]

positive regulation of cholesterol storage

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of sphingolipid mediated signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

regulation of sphingolipid mediated signaling pathway [inference]

positive regulation of sphingolipid mediated signaling pathway

regulation of intracellular signal transduction [inference]

regulation of nitric oxide mediated signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of sphingolipid mediated signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

regulation of cellular process [inference]

signal transduction [inference]

lipoprotein particle mediated signaling [inference]

high density lipoprotein particle mediated signaling

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of sphingolipid mediated signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

regulation of sphingolipid mediated signaling pathway [inference]

positive regulation of sphingolipid mediated signaling pathway

regulation of intracellular signal transduction [inference]

regulation of nitric oxide mediated signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of sphingolipid mediated signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

regulation of lipid storage [inference]

positive regulation of lipid storage [inference]

positive regulation of cholesterol storage

regulation of cholesterol storage [inference]

positive regulation of cholesterol storage

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of triglyceride biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride biosynthetic process

regulation of catabolic process [inference]

regulation of lipid catabolic process [inference]

regulation of phospholipid catabolic process [inference]

regulation of phosphatidylcholine catabolic process

regulation of phosphorus metabolic process [inference]

regulation of phospholipid metabolic process [inference]

regulation of phospholipid catabolic process [inference]

regulation of phosphatidylcholine catabolic process

regulation of phosphatidylcholine metabolic process [inference]

regulation of phosphatidylcholine catabolic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

positive regulation of lipid metabolic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of triglyceride biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

regulation of lipid catabolic process [inference]

regulation of phospholipid catabolic process [inference]

regulation of phosphatidylcholine catabolic process

regulation of triglyceride metabolic process [inference]

regulation of triglyceride biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride biosynthetic process

regulation of phospholipid metabolic process [inference]

regulation of phospholipid catabolic process [inference]

regulation of phosphatidylcholine catabolic process

regulation of phosphatidylcholine metabolic process [inference]

regulation of phosphatidylcholine catabolic process

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of sphingolipid mediated signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

positive regulation of lipid storage [inference]

positive regulation of cholesterol storage

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

vasodilation

Displaying **all 5** entries
GO Term	Evidence Code	Reference
lysosome
caveola	IBA	GO_REF
caveola	IEA	GO_REF GO_REF
cell surface	IBA	GO_REF
cell surface	IEA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cell surface

membrane [inference]

plasma membrane region [inference]

plasma membrane raft [inference]

caveola

membrane microdomain [inference]

membrane raft [inference]

plasma membrane raft [inference]

caveola

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	Reference
lipopolysaccharide binding	IEA	GO_REF
amyloid-beta binding	IEA	GO_REF
lipopolysaccharide immune receptor activity	IEA	GO_REF
scavenger receptor activity	IBA	GO_REF
high-density lipoprotein particle binding	IEA	GO_REF

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

apolipoprotein binding [inference]

apolipoprotein A-I binding

lipid binding

lipopolysaccharide binding

peptide binding [inference]

amyloid-beta binding

protein-containing complex binding [inference]

protein-lipid complex binding [inference]

lipoprotein particle binding [inference]

carbohydrate derivative binding [inference]

lipopolysaccharide binding

cargo receptor activity [inference]

scavenger receptor activity

lipoprotein particle receptor activity [inference]

high-density lipoprotein particle receptor activity

molecular transducer activity [inference]

signaling receptor activity [inference]

pattern recognition receptor activity [inference]

lipopolysaccharide immune receptor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MGNLSRARRVTAALGFIGLLFAVLGIIMIVMVPSIIKQQVLKNVRIDPNSLSFNMWKEIPVPFYLSVYFFNIVNPEGIIQGQKPQVQEHGPYVYREFRHKSNITFNNNDTVSFLEYRSYQFQPDKSRGQESDYIVMPNILVLSASMMMENRPGLLKLMMTLAFSTLGQRAFMNRTVGEIMWGYDDPLIHLINQYFPNSLPFKGKFGLFAELNNSDSGLFTVFTGVKNFSRIHLVDKWNGVSKVNYWHSDQCNMINGTSGQMWAPFMTPESSLEFYSPEACRSMKLVYKEQGVFGGIPTFRFVAPSTLFANGSVYPPNEGFCPCRESGIQNVSTCRFNAPLFLSHPHFYNADPVLAEAVSGLHPNPKEHSLFLDIHPVTGIPMNCSVKLQLSLFVKSVKGIGQTGNIQPVVLPLMWFEESGAMEGETLETFYIQLVLMPKVLHYAQYVLLALGCVLLLIPIIYQIRSQEKCYLFWISFKKGSKDKEAVQAYSEFLMTSAPKGTVLQEARL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 9** entries
Position	Description	Source
102	N-linked (GlcNAc...) asparagine	UniProt
108	N-linked (GlcNAc...) asparagine	UniProt
173	N-linked (GlcNAc...) asparagine	UniProt
212	N-linked (GlcNAc...) asparagine	UniProt
227	N-linked (GlcNAc...) asparagine	UniProt
255	N-linked (GlcNAc...) asparagine	UniProt
310	N-linked (GlcNAc...) asparagine	UniProt
330	N-linked (GlcNAc...) asparagine	UniProt
383	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 2** entries
Pathway Name	Organism
HDL clearance	Bos taurus
Scavenging by Class B Receptors	Bos taurus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

International Collaboration

Acknowledgements