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NPC intracellular cholesterol transporter 1

Summary

UniProt ID

O35604

Gene Symbol

Npc1

Gene ID

18145

Organism

Mus musculus (house mouse)

External Links

GlycoProtDB

GPDB0003118

GlyConnect

Niemann-Pick C1 protein

GlyGen

O35604

PubChem

O35604

SwissLipids

SLP:000000479

RaftProt

O35604

Re-Glyco

O35604

Annotation

Keyword

Cholesterol metabolism
Disulfide bond
Endosome
Glycoprotein
Lipid transport
Lysosome
Reference proteome
Signal
Transmembrane helix

Gene Ontology (GO)

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GO Term
extracellular region
nuclear envelope
lysosome
plasma membrane
membrane
vesicle
endosome
endoplasmic reticulum
Golgi apparatus
perinuclear region of cytoplasm

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

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GO Term
lysosomal transport
cholesterol storage
sterol transport
membrane raft organization
intracellular lipid transport
intracellular cholesterol transport
cyclodextrin metabolic process
autophagy
cholesterol metabolic process
response to xenobiotic stimulus

Displaying **all 2** entries
GO Term
cholesterol transfer activity
cholesterol binding

Annotation information from UniProt.

Sequence

MGAHHPALGLLLLLLCPAQVFSQSCVWYGECGIATGDKRYNCKYSGPPKPLPKDGYDLVQELCPGLFFDNVSLCCDIQQLQTLKSNLQLPLQFLSRCPSCFYNLMTLFCELTCSPHQSQFLNVTATEDYFDPKTQENKTNVKELEYFVGQSFANAMYNACRDVEAPSSNEKALGLLCGRDARACNATNWIEYMFNKDNGQAPFTIIPVFSDLSILGMEPMRNATKGCNESVDEVTGPCSCQDCSIVCGPKPQPPPPPMPWRIWGLDAMYVIMWVTYVAFLFVFFGALLAVWCHRRRYFVSEYTPIDSNIAFSVNSSDKGEASCCDPLGAAFDDCLRRMFTKWGAFCVRNPTCIIFFSLAFITVCSSGLVFVQVTTNPVELWSAPHSQARLEKEYFDKHFGPFFRTEQLIIQAPNTSVHIYEPYPAGADVPFGPPLNKEILHQVLDLQIAIESITASYNNETVTLQDICVAPLSPYNKNCTIMSVLNYFQNSHAVLDSQVGDDFYIYADYHTHFLYCVRAPASLNDTSLLHGPCLGTFGGPVFPWLVLGGYDDQNYNNATALVITFPVNNYYNDTERLQRAWAWEKEFISFVKNYKNPNLTISFTAERSIEDELNRESNSDVFTVIISYVVMFLYISLALGHIQSCSRLLVDSKISLGIAGILIVLSSVACSLGIFSYMGMPLTLIVIEVIPFLVLAVGVDNIFILVQTYQRDERLQEETLDQQLGRILGEVAPTMFLSSFSETSAFFFGALSSMPAVHTFSLFAGMAVLIDFLLQITCFVSLLGLDIKRQEKNHLDILCCVRGADDGQGSHASESYLFRFFKNYFAPLLLKDWLRPIVVAVFVGVLSFSVAVVNKVDIGLDQSLSMPNDSYVIDYFKSLAQYLHSGPPVYFVLEEGYNYSSRKGQNMVCGGMGCDNDSLVQQIFNAAELDTYTRVGFAPSSWIDDYFDWVSPQSSCCRLYNVTHQFCNASVMDPTCVRCRPLTPEGKQRPQGKEFMKFLPMFLSDNPNPKCGKGGHAAYGSAVNIVGDDTYIGATYFMTYHTILKTSADYTDAMKKARLIASNITETMRSKGSDYRVFPYSVFYVFYEQYLTIIDDTIFNLSVSLGSIFLVTLVVLGCELWSAVIMCITIAMILVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTMSTKGSRVSRAEEALAHMGSSVFSGITLTKFGGIVVLAFAKSQIFEIFYFRMYLAMVLLGATHGLIFLPVLLSYIGPSVNKAKRHTTYERYRGTERERLLNF

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

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Position	Description	GlyTouCan ID	Source
70	N-linked (GlcNAc...) asparagine		UniProt GlyGen
122	N-linked (GlcNAc...) asparagine		UniProt GlyGen
137	N-linked (GlcNAc...) asparagine		UniProt GlyGen
185	N-linked (GlcNAc...) asparagine		GlycoProtDB UniProt GlyGen
222	N-linked (GlcNAc...) asparagine	G92942VI	UniProt GlyGen
228	N-linked (GlcNAc...) asparagine	G31852PQ	UniProt GlyGen
314		G17023GV	GlyGen
414	N-linked (GlcNAc...) asparagine	G58053OY	GlycoProtDB UniProt GlyGen
459	N-linked (GlcNAc...) asparagine		UniProt GlyGen
478	N-linked (GlcNAc...) asparagine		UniProt GlyGen