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Excitatory amino acid transporter 4

Summary

UniProt ID

O35921

Gene Symbol

Eaat4
Slc1a6

Gene ID

[84012]

Organism

Rattus norvegicus (Norway rat)

External Links

PubChem: O35921
Re-Glyco: O35921

Annotation

Keyword: Amino-acid transport Cell membrane Chloride Glycoprotein Metal-binding Phosphoprotein Potassium Reference proteome Sodium Symport Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	Reference
neurotransmitter uptake	ISO	GO_REF
L-glutamate transmembrane transport	ISO	GO_REF
L-glutamate transmembrane transport	IDA	PMID
L-glutamate transmembrane transport	IBA	GO_REF
regulation of membrane potential	ISO	GO_REF

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

carboxylic acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

localization [inference]

establishment of localization [inference]

transport [inference]

neurotransmitter transport [inference]

neurotransmitter uptake

amino acid transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

acidic amino acid transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

organic anion transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

C4-dicarboxylate transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

carboxylic acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

organic acid transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

C4-dicarboxylate transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

carboxylic acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

carboxylic acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

nitrogen compound transport [inference]

L-amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

import into cell [inference]

neurotransmitter uptake

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

establishment of localization in cell

biological regulation [inference]

regulation of biological quality [inference]

regulation of membrane potential

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	Reference
Golgi apparatus	ISO	GO_REF
plasma membrane	ISO	GO_REF
plasma membrane	IMP	PMID
plasma membrane	IBA	GO_REF
plasma membrane	IEA	GO_REF GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex

cellular anatomical structure [inference]

membrane

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

cell junction [inference]

synapse [inference]

excitatory synapse [inference]

parallel fiber to Purkinje cell synapse

glutamatergic synapse

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

membraneless organelle [inference]

intracellular membraneless organelle [inference]

cytoskeleton [inference]

intermediate filament cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular membraneless organelle [inference]

cytoskeleton [inference]

intermediate filament cytoskeleton

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	Reference
L-glutamate transmembrane transporter activity	ISO	GO_REF
L-glutamate transmembrane transporter activity	TAS	PMID
L-glutamate transmembrane transporter activity	IBA	GO_REF
L-glutamate transmembrane transporter activity	IEA	GO_REF
high-affinity L-glutamate transmembrane transporter activity	IDA	PMID

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

solute:sodium symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

organic acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

organic acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

monoatomic anion transmembrane transporter activity

amino acid transmembrane transporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

acidic amino acid transmembrane transporter activity [inference]

L-glutamate transmembrane transporter activity

high-affinity L-glutamate transmembrane transporter activity

L-aspartate transmembrane transporter activity

neutral L-amino acid transmembrane transporter activity

L-amino acid transmembrane transporter activity [inference]

L-glutamate transmembrane transporter activity

high-affinity L-glutamate transmembrane transporter activity

L-aspartate transmembrane transporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity [inference]

solute:monoatomic cation symporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

solute:sodium symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

organic acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

carboxylic acid transmembrane transporter activity [inference]

dicarboxylic acid transmembrane transporter activity [inference]

L-aspartate transmembrane transporter activity

L-amino acid transmembrane transporter activity [inference]

L-glutamate transmembrane transporter activity

high-affinity L-glutamate transmembrane transporter activity

L-aspartate transmembrane transporter activity

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

C4-dicarboxylate transmembrane transporter activity [inference]

L-aspartate transmembrane transporter activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MSSHGNSLFLRESGAGGGCLQGLQDSLQQRALRTRLRLQTMTREHVRRFLRRNAFILLTVSAVIIGVSLAFALRPYQLTYRQIKYFSFPGELLMRMLQMLVLPLIVSSRVTGMASLDNKATGRMGMRAAVYYMVTTVIAVFIGILMVTIIHPGKGSKEGLHREGRIETVPTADAFMDLVRNMFPPNLVEACFKQFKTQYSTRVVTRTIVRTDNGSELGASISPPSSAENETSILENVTRALGTLQEVISFEETVPVPGSANGINALGLVVFSVAFGLVIGGMKHKGRVLRDFFDSLNEAIMRLVGIIIWYAPVGILFLIAGKILEMEDMAVLGGQLGMYTLTVIVGLFLHAGGVLPLIYFLVTHRNPFPFIGGILQALITAMGTSSSSATLPITFRCLEEGLGVDRRITRFVLPVGATVNMDGTALYEALAAIFIAQVNNYELNLGQITTISITATAASVGAAGIPQAGLVTMVIVLTSVGLPTEDITLIIAVDWFLDRLRTMTNVLGDSIGAAVIEHLSQRELELQEAELTLPSLGKPYKSLMAQAKGASRGRGGNESVM

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites