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Zona pellucida sperm-binding protein 2

Summary

UniProt ID: O54767
Gene Symbol: Zp2 Zpa
Gene ID: 81828
Organism: Rattus norvegicus (Norway rat)

External Links

GlyGen: O54767
Re-Glyco: O54767

Annotation

Keyword: Cell membrane Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Extracellular matrix Fertilization Glycoprotein Receptor Reference proteome Signal Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	Reference
humoral immune response mediated by circulating immunoglobulin	ISO	GO_REF
binding of sperm to zona pellucida	ISS	PMID
binding of sperm to zona pellucida	ISO	GO_REF
binding of sperm to zona pellucida	IBA	GO_REF
prevention of polyspermy	ISS	PMID

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

leukocyte mediated immunity [inference]

lymphocyte mediated immunity [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response [inference]

humoral immune response mediated by circulating immunoglobulin

immune response [inference]

adaptive immune response [inference]

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response [inference]

humoral immune response mediated by circulating immunoglobulin

humoral immune response [inference]

humoral immune response mediated by circulating immunoglobulin

cellular process [inference]

cell recognition [inference]

cell-cell recognition [inference]

sperm-egg recognition [inference]

binding of sperm to zona pellucida

response to stimulus [inference]

immune response [inference]

adaptive immune response [inference]

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response [inference]

humoral immune response mediated by circulating immunoglobulin

humoral immune response [inference]

humoral immune response mediated by circulating immunoglobulin

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of reproductive process [inference]

negative regulation of fertilization [inference]

prevention of polyspermy

regulation of reproductive process [inference]

regulation of fertilization [inference]

negative regulation of fertilization [inference]

prevention of polyspermy

negative regulation of reproductive process [inference]

negative regulation of fertilization [inference]

prevention of polyspermy

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	Reference
multivesicular body	ISS	GO_REF
multivesicular body	ISO	GO_REF
endoplasmic reticulum	ISS	GO_REF
endoplasmic reticulum	ISO	GO_REF
plasma membrane	ISS	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

intracellular anatomical structure [inference]

inclusion body

membrane [inference]

plasma membrane

external encapsulating structure [inference]

extracellular matrix

specialized extracellular matrix [inference]

egg coat

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome [inference]

multivesicular body

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome [inference]

multivesicular body

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome [inference]

multivesicular body

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	Reference
acrosin binding	ISO	GO_REF
acrosin binding	IBA	GO_REF
structural constituent of egg coat	ISS	GO_REF
structural constituent of egg coat	ISO	GO_REF
structural constituent of egg coat	IBA	GO_REF

GO Hierarchy

molecular function

structural molecule activity [inference]

extracellular matrix structural constituent [inference]

structural constituent of egg coat

binding [inference]

protein binding [inference]

enzyme binding [inference]

acrosin binding

identical protein binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MARWQRVYWLRSLFFALVTSVNSLSLPQSENPAFPGTLICDKDEVRVEFSSRFDMEKWNPSLVDTFGNEISNCTYALDLEKFILKFPYETCTIKVIGGYQVNIRVQDTNADVSYKDDVHHFFCPAIQAEIHEVSEIVVCMEDLISFSFPQLFSRLADENQNVSEMGWIIKIGNGTRVHTLPLKDAIVQGFNLLIDSQKITLHVPANATGVAHYVQESSYLYTVQLKLLFSSPGQKITFSSQAICAPDLSVACNVTHMSLTIPEFPGKLKSVGFGQRNIPEDQWHANGIDKEATNGLRLHFRKSLLKTKPSEKCPFYQFYFSSLELTFNFQGDMLSTVIDPECHCESPVSIDELCTRDGFMDFEVYSHQTKPALNLESLLVGNSSCQPIFKVQSLGLARFHIPLNGCGTRQKFEGDKVIYENEIHALWENPPSNIIFRNSEFRMTVRCHYIRDSMLLRAHIKSHSSPVASVKPGPLALVLQTYPDISYQRPYRKNEYPLVRYLRQPIYMEVTVLNRNDPNIKLVLDDCWATTFEDPASVPQWQIIMDGCEYELDNYRTTFHAANSSAAHSGHYQRFDVKTFAFVSESRGLSSLIYFHCSALICNQASPLCSVTCPAPLRNKREASKEGTMTVSLPGPIILLSDDSSSKGVMNPDSYEITKDIASKTLGAVAALVGSAVIIGFICYLHKKRIVRFNS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 8** entries
Position	Description	PubMed ID	Source
72	N-linked (GlcNAc...) asparagine; partial	16342937	UniProt GlyGen
161	N-linked (GlcNAc...) asparagine; partial	16342937	UniProt GlyGen
173	N-linked (GlcNAc...) asparagine	16342937	UniProt GlyGen
206	N-linked (GlcNAc...) asparagine	16342937	UniProt GlyGen
253	N-linked (GlcNAc...) asparagine	16342937	UniProt GlyGen
382	N-linked (GlcNAc...) asparagine	16342937	UniProt GlyGen
444	O-linked (GalNAc...) threonine		UniProt GlyGen
563	N-linked (GlcNAc...) asparagine	16342937	UniProt GlyGen