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Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

Summary

UniProt ID: O55143
Gene Symbol: Atp2a2
Gene ID: 11938
Organism: Mus musculus (house mouse)

External Links

GlyGen: O55143
PubChem: O55143
RaftProt: O55143
O-GlcNAcAtlas: O55143
Re-Glyco: O55143

Annotation

Keyword: ATP-binding Alternative splicing Calcium transport Direct protein sequencing Disulfide bond Endoplasmic reticulum Magnesium Metal-binding Nitration Phosphoprotein Reference proteome Sarcoplasmic reticulum Translocase Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 51 in total

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GO Term	Evidence Code	Reference
autophagosome assembly	ISS	GO_REF
autophagosome assembly	ISO	GO_REF
autophagosome assembly	IBA	GO_REF
autophagosome assembly	IEA	GO_REF
regulation of the force of heart contraction	IGI	PMID

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

ER-nucleus signaling pathway

intracellular signaling cassette [inference]

calcium-mediated signaling [inference]

regulation of cardiac muscle contraction by calcium ion signaling

intercellular transport [inference]

cytosol to endoplasmic reticulum transport [inference]

calcium ion transport from cytosol to endoplasmic reticulum

membrane docking [inference]

organelle localization by membrane tethering

cellular localization [inference]

intracellular transport [inference]

cytosol to endoplasmic reticulum transport [inference]

calcium ion transport from cytosol to endoplasmic reticulum

calcium ion import into sarcoplasmic reticulum

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transport from cytosol to endoplasmic reticulum

cytosol to endoplasmic reticulum transport [inference]

calcium ion transport from cytosol to endoplasmic reticulum

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vacuole organization [inference]

autophagosome organization [inference]

autophagosome assembly

organelle assembly [inference]

autophagosome assembly

cellular component assembly [inference]

organelle assembly [inference]

autophagosome assembly

membrane organization [inference]

T-tubule organization

mitochondrion-endoplasmic reticulum membrane tethering

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle hypertrophy [inference]

muscle hypertrophy in response to stress [inference]

cardiac muscle hypertrophy in response to stress

striated muscle hypertrophy [inference]

cardiac muscle hypertrophy [inference]

cardiac muscle hypertrophy in response to stress

muscle adaptation [inference]

muscle hypertrophy in response to stress [inference]

cardiac muscle hypertrophy in response to stress

striated muscle adaptation [inference]

cardiac muscle adaptation [inference]

cardiac muscle hypertrophy in response to stress

relaxation of muscle [inference]

relaxation of cardiac muscle

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

endoplasmic reticulum calcium ion homeostasis

positive regulation of endoplasmic reticulum calcium ion concentration

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

endoplasmic reticulum calcium ion homeostasis

positive regulation of endoplasmic reticulum calcium ion concentration

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

endoplasmic reticulum calcium ion homeostasis

positive regulation of endoplasmic reticulum calcium ion concentration

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

endoplasmic reticulum calcium ion homeostasis

positive regulation of endoplasmic reticulum calcium ion concentration

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

endoplasmic reticulum calcium ion homeostasis

positive regulation of endoplasmic reticulum calcium ion concentration

inorganic ion homeostasis [inference]

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

endoplasmic reticulum calcium ion homeostasis

positive regulation of endoplasmic reticulum calcium ion concentration

response to stimulus [inference]

response to stress [inference]

muscle hypertrophy in response to stress [inference]

cardiac muscle hypertrophy in response to stress

response to oxidative stress [inference]

cellular response to oxidative stress

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone

response to chemical [inference]

response to hormone [inference]

response to peptide hormone

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

response to nitrogen compound [inference]

response to peptide hormone

response to oxygen-containing compound [inference]

response to peptide hormone

muscle adaptation [inference]

muscle hypertrophy in response to stress [inference]

cardiac muscle hypertrophy in response to stress

striated muscle adaptation [inference]

cardiac muscle adaptation [inference]

cardiac muscle hypertrophy in response to stress

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport

sarcoplasmic reticulum calcium ion transport

calcium ion import into sarcoplasmic reticulum

calcium ion transmembrane transport

calcium ion transport from cytosol to endoplasmic reticulum

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transport from cytosol to endoplasmic reticulum

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transport from cytosol to endoplasmic reticulum

intercellular transport [inference]

cytosol to endoplasmic reticulum transport [inference]

calcium ion transport from cytosol to endoplasmic reticulum

intracellular transport [inference]

cytosol to endoplasmic reticulum transport [inference]

calcium ion transport from cytosol to endoplasmic reticulum

calcium ion import into sarcoplasmic reticulum

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transport from cytosol to endoplasmic reticulum

cytosol to endoplasmic reticulum transport [inference]

calcium ion transport from cytosol to endoplasmic reticulum

establishment of localization in cell [inference]

intracellular transport [inference]

cytosol to endoplasmic reticulum transport [inference]

calcium ion transport from cytosol to endoplasmic reticulum

calcium ion import into sarcoplasmic reticulum

organelle localization [inference]

organelle localization by membrane tethering

cellular localization [inference]

intracellular transport [inference]

cytosol to endoplasmic reticulum transport [inference]

calcium ion transport from cytosol to endoplasmic reticulum

calcium ion import into sarcoplasmic reticulum

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis [inference]

regulation of calcium ion-dependent exocytosis of neurotransmitter

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of calcium ion-dependent exocytosis [inference]

regulation of calcium ion-dependent exocytosis of neurotransmitter

regulation of synaptic vesicle exocytosis [inference]

regulation of calcium ion-dependent exocytosis of neurotransmitter

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis [inference]

regulation of calcium ion-dependent exocytosis of neurotransmitter

regulation of neurotransmitter transport [inference]

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis [inference]

regulation of calcium ion-dependent exocytosis of neurotransmitter

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of calcium ion-dependent exocytosis [inference]

regulation of calcium ion-dependent exocytosis of neurotransmitter

regulation of synaptic vesicle exocytosis [inference]

regulation of calcium ion-dependent exocytosis of neurotransmitter

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of muscle cell apoptotic process [inference]

positive regulation of striated muscle cell apoptotic process [inference]

positive regulation of cardiac muscle cell apoptotic process

negative regulation of biological process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of blood circulation [inference]

negative regulation of heart contraction

regulation of response to stimulus [inference]

regulation of muscle adaptation [inference]

regulation of skeletal muscle adaptation [inference]

transition between fast and slow fiber

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

ER-nucleus signaling pathway

intracellular signaling cassette [inference]

calcium-mediated signaling [inference]

regulation of cardiac muscle contraction by calcium ion signaling

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis [inference]

regulation of calcium ion-dependent exocytosis of neurotransmitter

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

regulation of muscle cell apoptotic process [inference]

positive regulation of muscle cell apoptotic process [inference]

positive regulation of striated muscle cell apoptotic process [inference]

positive regulation of cardiac muscle cell apoptotic process

regulation of striated muscle cell apoptotic process [inference]

positive regulation of striated muscle cell apoptotic process [inference]

positive regulation of cardiac muscle cell apoptotic process

regulation of cardiac muscle cell apoptotic process [inference]

positive regulation of cardiac muscle cell apoptotic process

positive regulation of apoptotic process [inference]

positive regulation of muscle cell apoptotic process [inference]

positive regulation of striated muscle cell apoptotic process [inference]

positive regulation of cardiac muscle cell apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of muscle cell apoptotic process [inference]

positive regulation of striated muscle cell apoptotic process [inference]

positive regulation of cardiac muscle cell apoptotic process

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of muscle cell apoptotic process [inference]

positive regulation of striated muscle cell apoptotic process [inference]

positive regulation of cardiac muscle cell apoptotic process

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of calcium ion-dependent exocytosis [inference]

regulation of calcium ion-dependent exocytosis of neurotransmitter

regulation of synaptic vesicle exocytosis [inference]

regulation of calcium ion-dependent exocytosis of neurotransmitter

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of calcium ion-dependent exocytosis [inference]

regulation of calcium ion-dependent exocytosis of neurotransmitter

regulation of synaptic vesicle exocytosis [inference]

regulation of calcium ion-dependent exocytosis of neurotransmitter

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis [inference]

regulation of calcium ion-dependent exocytosis of neurotransmitter

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of muscle system process [inference]

regulation of muscle contraction

regulation of striated muscle contraction [inference]

regulation of cardiac muscle contraction [inference]

regulation of cardiac muscle contraction by calcium ion signaling

regulation of muscle adaptation [inference]

regulation of skeletal muscle adaptation [inference]

transition between fast and slow fiber

regulation of blood circulation [inference]

regulation of heart contraction [inference]

regulation of cardiac muscle contraction [inference]

regulation of cardiac muscle contraction by calcium ion signaling

negative regulation of blood circulation [inference]

negative regulation of heart contraction

negative regulation of multicellular organismal process [inference]

negative regulation of blood circulation [inference]

negative regulation of heart contraction

regulation of action potential [inference]

regulation of cardiac muscle cell action potential [inference]

regulation of cardiac muscle cell action potential involved in regulation of contraction

regulation of biological quality [inference]

regulation of the force of heart contraction

regulation of membrane potential [inference]

regulation of cardiac muscle cell membrane potential

regulation of action potential [inference]

regulation of cardiac muscle cell action potential [inference]

regulation of cardiac muscle cell action potential involved in regulation of contraction

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GO Term	Evidence Code	Reference
endoplasmic reticulum	ISO	PMID GO_REF
endoplasmic reticulum	IDA	PMID
endoplasmic reticulum	IEA	GO_REF
endoplasmic reticulum membrane	ISO	GO_REF
endoplasmic reticulum membrane	EXP	PMID PMID

GO Hierarchy

cellular component

protein-containing complex

membrane protein complex [inference]

transmembrane transporter complex [inference]

ATPase dependent transmembrane transport complex [inference]

cation-transporting ATPase complex [inference]

calcium ion-transporting ATPase complex

transporter complex [inference]

transmembrane transporter complex [inference]

ATPase dependent transmembrane transport complex [inference]

cation-transporting ATPase complex [inference]

calcium ion-transporting ATPase complex

cellular anatomical structure [inference]

longitudinal sarcoplasmic reticulum

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

sarcoplasmic reticulum membrane

bounding membrane of organelle [inference]

sarcoplasmic reticulum membrane

extrinsic component of membrane [inference]

extrinsic component of plasma membrane [inference]

extrinsic component of cytoplasmic side of plasma membrane

cell junction [inference]

synapse [inference]

ribbon synapse

anchoring junction [inference]

cell-cell junction [inference]

apical ectoplasmic specialization

cell projection [inference]

plasma membrane bounded cell projection

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

sarcoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

sarcoplasmic reticulum

perinuclear region of cytoplasm

Displaying entries **1 - 5** of 26 in total

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GO Term	Evidence Code	Reference
calcium channel regulator activity	ISO	GO_REF
calcium channel regulator activity	IEA	GO_REF
P-type calcium transporter activity	ISO	GO_REF GO_REF
P-type calcium transporter activity	EXP	PMID
P-type calcium transporter activity	IDA	PMID PMID

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

P-type calcium transporter activity

P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential

metal ion transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

P-type calcium transporter activity

P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential

active monoatomic ion transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

P-type calcium transporter activity

P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

active monoatomic ion transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

P-type calcium transporter activity

P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential

ATPase-coupled transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

P-type calcium transporter activity

P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential

P-type transmembrane transporter activity [inference]

P-type ion transporter activity [inference]

P-type calcium transporter activity

P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential

binding [inference]

nucleic acid binding [inference]

RNA binding [inference]

lncRNA binding

protein binding [inference]

signaling receptor binding [inference]

G protein-coupled receptor binding [inference]

lutropin-choriogonadotropic hormone receptor binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding [inference]

calcium ion binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

molecular function regulator activity [inference]

transporter regulator activity [inference]

channel regulator activity [inference]

ion channel regulator activity [inference]

calcium channel regulator activity

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

P-type calcium transporter activity

P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential

P-type transmembrane transporter activity [inference]

P-type ion transporter activity [inference]

P-type calcium transporter activity

P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLLELVIEQFEDLLVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAVGDKVPADIRLTSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSKVISLICIAVWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDKVEGDTCSLNEFSITGSTYAPIGEVQKDDKPVKCHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPEGVIDRCTHIRVGSTKVPMTPGVKQKIMSVIREWGSGSDTLRCLALATHDNPLKREEMHLEDSANFIKYETNLTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMITGDNKGTAVAICRRIGIFGQDEDVTSKAFTGREFDELSPSAQRDACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKSEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVGAATVGAAAWWFIAADGGPRVSFYQLSHFLQCKEDNPDFDGVDCAIFESPYPMTMALSVLVTIEMCNALNSLSENQSLLRMPPWENIWLVGSICLSMSLHFLILYVEPLPLIFQITPLNLTQWLMVLKISLPVILMDETLKFVARNYLEQPGKECVQPATKSSCSLSACTDGISWPFVLLIMPLVVWVYSTDTNFSDMFWS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
210			G49108TO	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 3** entries
Pathway Name	Organism
Ion homeostasis	Mus musculus
Ion transport by P-type ATPases	Mus musculus
Reduction of cytosolic Ca++ levels	Mus musculus

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:2734	keratosis follicularis	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Acknowledgements