GlyCosmos Portal

Submissions

E3 ubiquitin-protein ligase MGRN1

Summary

UniProt ID: O60291
Gene Symbol: MGRN1 KIAA0544 RNF156
Gene ID: 23295
Organism: Homo sapiens (human)

External Links

The Human Metabolome Database: HMDBP09273
The O-GlcNAc Database: O60291
RaftProt: O60291
Re-Glyco: O60291

Annotation

Keyword: Alternative splicing Cell membrane Cytoplasm Endosome Myristate Nucleus Phosphoprotein Proteomics identification Reference proteome Transferase Ubl conjugation Ubl conjugation pathway Zinc-finger

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

1

2

3

Next ›

Last »
GO Term	Evidence Code	Reference
protein polyubiquitination
protein monoubiquitination	IMP	PMID
smoothened signaling pathway	IBA	GO_REF
heart development
endosome to lysosome transport	IMP	PMID

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

smoothened signaling pathway

metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

intercellular transport [inference]

endosome to lysosome transport

vesicle-mediated transport [inference]

endosome to lysosome transport

cellular localization [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly

protein-containing complex organization [inference]

protein-containing complex assembly

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

heart development

localization [inference]

establishment of localization [inference]

transport [inference]

intercellular transport [inference]

endosome to lysosome transport

vesicle-mediated transport [inference]

endosome to lysosome transport

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport

establishment of localization in cell [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport

cellular localization [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of G protein-coupled receptor signaling pathway

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of smoothened signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of smoothened signaling pathway

positive regulation of biological process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of behavior [inference]

positive regulation of feeding behavior [inference]

positive regulation of eating behavior

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of smoothened signaling pathway

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of secondary metabolite biosynthetic process [inference]

negative regulation of melanin biosynthetic process

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of smoothened signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of smoothened signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of G protein-coupled receptor signaling pathway

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of smoothened signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of smoothened signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

smoothened signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of G protein-coupled receptor signaling pathway

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of smoothened signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of smoothened signaling pathway

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of secondary metabolite biosynthetic process [inference]

negative regulation of melanin biosynthetic process

regulation of secondary metabolite biosynthetic process [inference]

regulation of melanin biosynthetic process [inference]

negative regulation of melanin biosynthetic process

negative regulation of secondary metabolite biosynthetic process [inference]

negative regulation of melanin biosynthetic process

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of secondary metabolite biosynthetic process [inference]

negative regulation of melanin biosynthetic process

regulation of secondary metabolic process [inference]

regulation of secondary metabolite biosynthetic process [inference]

regulation of melanin biosynthetic process [inference]

negative regulation of melanin biosynthetic process

negative regulation of secondary metabolite biosynthetic process [inference]

negative regulation of melanin biosynthetic process

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of secondary metabolite biosynthetic process [inference]

negative regulation of melanin biosynthetic process

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of smoothened signaling pathway

regulation of multicellular organismal process [inference]

regulation of behavior [inference]

positive regulation of behavior [inference]

positive regulation of feeding behavior [inference]

positive regulation of eating behavior

regulation of feeding behavior [inference]

regulation of eating behavior [inference]

positive regulation of eating behavior

positive regulation of feeding behavior [inference]

positive regulation of eating behavior

positive regulation of multicellular organismal process [inference]

positive regulation of behavior [inference]

positive regulation of feeding behavior [inference]

positive regulation of eating behavior

Displaying entries **1 - 5** of 16 in total

1

2

3

4

Next ›

Last »
GO Term	Evidence Code	Reference
ubiquitin ligase complex
nucleus	EXP	PMID
nucleus	IDA	PMID PMID
nucleus	IEA	GO_REF
cytoplasm	IDA	PMID PMID

GO Hierarchy

cellular component

protein-containing complex [inference]

intracellular protein-containing complex [inference]

ubiquitin ligase complex

catalytic complex [inference]

transferase complex [inference]

ubiquitin ligase complex

cellular anatomical structure [inference]

membrane

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 6 in total

1

2

Next ›

Last »
GO Term	Evidence Code	Reference
ubiquitin-protein transferase activity	IDA	PMID PMID
ubiquitin-protein transferase activity	IEA	GO_REF
zinc ion binding
ubiquitin protein ligase activity	IBA	GO_REF
ubiquitin protein ligase activity	IEA	GO_REF GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

aminoacyltransferase activity [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity

ubiquitin protein ligase activity

ubiquitin-like protein ligase activity [inference]

ubiquitin protein ligase activity

catalytic activity, acting on a protein [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity

ubiquitin protein ligase activity

ubiquitin-like protein ligase activity [inference]

ubiquitin protein ligase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

molecular sequestering activity [inference]

protein sequestering activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MGSILSRRIAGVEDIDIQANSAYRYPPKSGNYFASHFFMGGEKFDTPHPEGYLFGENMDLNFLGSRPVQFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRYKDDADSPTEDGDKPRVLYSLEFTFDADARVAITIYCQASEEFLNGRAVYSPKSPSLQSETVHYKRGVSQQFSLPSFKIDFSEWKDDELNFDLDRGVFPVVIQAVVDEGDVVEVTGHAHVLLAAFEKHMDGSFSVKPLKQKQIVDRVSYLLQEIYGIENKNNQETKPSDDENSDNSNECVVCLSDLRDTLILPCRHLCLCTSCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPVSFSPVLAQSLEHDEHSCPFKKSKPHPASLASKKPKRETNSDSVPPGYEPISLLEALNGLRAVSPAIPSAPLYEEITYSGISDGLSQASCPLAAIDHILDSSRQKGRPQSKAPDSTLRSPSSPIHEEDEEKLSEDVDAPPPLGGAELALRESSSPESFITEEVDESSSPQQGTRAASIENVLQDSSPEHCGRGPPADIYLPALGPDSCSVGIDE

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites