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MIRAGE
NKG2-D type II integral membrane protein
Summary
- UniProt ID
- O70215
- Gene Symbol
- Klrk1 Nkg2d Nkrp2
- Gene ID
- 24934
- Organism
- Rattus norvegicus (Norway rat)
Annotation
- Keyword
- Adaptive immunity Cell membrane Differentiation Disulfide bond Glycoprotein Innate immunity Lectin Receptor Reference proteome Signal-anchor Transmembrane helix
Gene Ontology (GO)
| GO Term | Evidence Code | Reference |
|---|---|---|
| stimulatory C-type lectin receptor signaling pathway | ||
| adaptive immune response |
|
|
| positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target | ||
| natural killer cell activation | ||
| cell differentiation |
|
|
GO Hierarchy
biological process
immune system process [inference]
cellular process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
positive regulation of immune system process [inference]
regulation of leukocyte migration [inference]
regulation of immune effector process [inference]
regulation of immune response [inference]
regulation of locomotion [inference]
positive regulation of biological process [inference]
positive regulation of immune system process [inference]
positive regulation of response to stimulus [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of response to biotic stimulus [inference]
regulation of response to external stimulus [inference]
positive regulation of response to stimulus [inference]
regulation of immune response [inference]
regulation of response to stress [inference]
regulation of cellular process [inference]
| GO Term | Evidence Code | Reference |
|---|---|---|
| plasma membrane | ||
| plasma membrane | ||
| external side of plasma membrane | ||
| external side of plasma membrane | ||
| cell surface |
| GO Term | Evidence Code | Reference |
|---|---|---|
| kinase binding | ||
| carbohydrate binding |
|
|
| MHC class Ib receptor activity | ||
| signaling receptor activity | ||
| signaling receptor activity |
GO Hierarchy
Sequence
MSKCHNYDLKPAKWDTSQEHQKQRSALPTSRPGENGIIRRRSSIEELKISPLFVVRVLVAAMTIRFTVITLTWLAVFITLLCNKEVSVSSREGYCGPCPNDWICHRNNCYQFFNENKAWNQSQASCLSQNSSLLKIYSKEEQDFLKLVKSYHWMGLVQSPANGSWQWEDGSSLSPNELTLVKTPSGTCAVYGSSFKAYTEDCSNPNTYICMKRAV
Glycosylation Sites
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| DAP12 signaling | Rattus norvegicus |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | Rattus norvegicus |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:4231 | histiocytoma |
