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Integrin beta-5

Summary

UniProt ID: O70309
Gene Symbol: Itgb5
Gene ID: 16419
Organism: Mus musculus (house mouse)

External Links

GlycoProtDB

GPDB0003173

GlyConnect

Integrin beta-5

GlyGen

O70309

PubChem

O70309

Re-Glyco

O70309

Annotation

Keyword: Alternative splicing Calcium Cell adhesion Cell membrane Disulfide bond EGF-like domain Glycoprotein Integrin Magnesium Metal-binding Phosphoprotein Receptor Reference proteome Repeat Signal Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	Reference
cell-matrix adhesion	ISO	GO_REF
cell-matrix adhesion	NAS	PMID
cell-matrix adhesion	IBA	GO_REF
transforming growth factor beta receptor signaling pathway	ISO	GO_REF
transforming growth factor beta receptor signaling pathway	IMP	PMID

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell-substrate adhesion [inference]

cell-matrix adhesion

cell adhesion mediated by integrin

cell-cell adhesion

epithelial cell-cell adhesion

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

transforming growth factor beta receptor signaling pathway

integrin-mediated signaling pathway

actin filament-based process [inference]

actin cytoskeleton organization [inference]

actomyosin structure organization [inference]

stress fiber assembly

cell motility [inference]

cell migration

wound healing, spreading of cells [inference]

wound healing, spreading of epidermal cells

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization [inference]

actomyosin structure organization [inference]

stress fiber assembly

cellular component assembly [inference]

actin filament bundle assembly [inference]

contractile actin filament bundle assembly [inference]

stress fiber assembly

supramolecular fiber organization [inference]

actin filament organization [inference]

actin filament bundle organization [inference]

actin filament bundle assembly [inference]

contractile actin filament bundle assembly [inference]

stress fiber assembly

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

transforming growth factor beta receptor signaling pathway

integrin-mediated signaling pathway

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	Reference
plasma membrane	TAS	Reactome
plasma membrane	IEA	GO_REF
focal adhesion	IDA	PMID
focal adhesion	IBA	GO_REF
focal adhesion	IEA	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

signaling receptor complex

plasma membrane signaling receptor complex [inference]

integrin complex

integrin alphav-beta5 complex

protein complex involved in cell adhesion [inference]

integrin complex

integrin alphav-beta5 complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

integrin complex

integrin alphav-beta5 complex

cellular anatomical structure [inference]

cell surface

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

cell leading edge

Displaying **all 5** entries
GO Term	Evidence Code	Reference
signaling receptor binding	ISO	GO_REF
integrin binding	IBA	GO_REF
integrin binding	IPI	PMID PMID
integrin binding	IEA	GO_REF
metal ion binding

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding

integrin binding

cell adhesion molecule binding [inference]

integrin binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

protein-containing complex binding [inference]

integrin binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MPRVPATLYACLLGLCALVPRLAGLNICTSGSATSCEECLLIHPKCAWCSKEYFGNPRSITSRCDLKANLIRNGCEGEIESPASSTHVLRNLPLSSKGSSATGSDVIQMTPQEIAVSLRPGEQTTFQLQVRQVEDYPVDLYYLMDLSLSMKDDLENIRSLGTKLAEEMRKLTSNFRLGFGSFVDKDISPFSYTAPRYQTNPCIGYKLFPNCVPSFGFRHLLPLTDRVDSFNEEVRKQRVSRNRDAPEGGFDAVLQAAVCKEKIGWRKDALHLLVFTTDDVPHIALDGKLGGLVQPHDGQCHLNEANEYTASNQMDYPSLALLGEKLAENNINLIFAVTKNHYMLYKNFTALIPGTTVEILHGDSKNIIQLIINAYSSIRAKVELSVWDQPEDLNLFFTATCQDGISYPGQRKCEGLKIGDTASFEVSVEARSCPGRQAAQSFTLRPVGFRDSLQVEVAYNCTCGCSTGLEPNSARCSGNGTYTCGLCECDPGYLGTRCECQEGENQSGYQNLCREAEGKPLCSGRGECSCNQCSCFESEFGRIYGPFCECDSFSCARNKGVLCSGHGECHCGECKCHAGYIGDNCNCSTDVSTCKAKDGQICSDRGRCVCGQCQCTEPGAFGETCEKCPTCPDACSSKRDCVECLLLHQGKPDNQTCHHQCKDEVITWVDTIVKDDQEAVLCFYKTAKDCVMMFSYTELPNGRSNLTVLREPECGSAPNAMTILLAVVGSILLIGMALLAIWKLLVTIHDRREFAKFQSERSRARYEMASNPLYRKPISTHTVDFAFNKFNKSYNGSV

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 7** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
347	N-linked (GlcNAc...) asparagine		G83460ZZ	UniProt GlyGen
460	N-linked (GlcNAc...) asparagine			UniProt GlyGen
479	N-linked (GlcNAc...) asparagine			GlycoProtDB UniProt GlyGen
505	N-linked (GlcNAc...) asparagine		G62765YT	UniProt GlyGen
586	N-linked (GlcNAc...) asparagine	30899004	G41247ZX G06110VR	UniProt GlyGen GlyConnect
654	N-linked (GlcNAc...) asparagine		G62765YT	GlycoProtDB UniProt GlyGen
705	N-linked (GlcNAc...) asparagine		G80920RR	UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 7** entries
Pathway Name	Organism
Cross-presentation of particulate exogenous antigens (phagosomes)	Mus musculus
ECM proteoglycans	Mus musculus
Integrin cell surface interactions	Mus musculus
Molecules associated with elastic fibres	Mus musculus
Smooth Muscle Contraction	Mus musculus
Syndecan interactions	Mus musculus
TGF-beta receptor signaling activates SMADs	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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