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Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

Summary

UniProt ID: O70507
Gene Symbol: Bcng3 Hcn4
Gene ID: 330953
Organism: Mus musculus (house mouse)

External Links

GlyGen: O70507
PubChem: O70507
O-GlcNAcAtlas: O70507
Re-Glyco: O70507

Annotation

Keyword: Cell membrane Glycoprotein Ligand-gated ion channel Phosphoprotein Potassium channel Reference proteome Sodium channel Transmembrane helix Voltage-gated channel cAMP-binding

Gene Ontology (GO)

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GO Term	Evidence Code	Reference
in utero embryonic development	IMP	PMID
regulation of heart rate	ISS	GO_REF
regulation of heart rate	ISO	GO_REF
regulation of heart rate	IEA	GO_REF
regulation of membrane depolarization	ISO	GO_REF

GO Hierarchy

biological process

cellular process [inference]

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to oxygen-containing compound [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

sodium ion import across plasma membrane

potassium ion transmembrane transport

potassium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

multicellular organismal process [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

developmental process [inference]

anatomical structure development [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

response to stimulus [inference]

response to chemical [inference]

response to organophosphorus [inference]

response to cAMP [inference]

cellular response to cAMP

response to cGMP [inference]

cellular response to cGMP

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to oxygen-containing compound [inference]

response to nitrogen compound [inference]

response to purine-containing compound [inference]

response to cAMP [inference]

cellular response to cAMP

response to cGMP [inference]

cellular response to cGMP

cellular response to nitrogen compound [inference]

response to oxygen-containing compound [inference]

response to cAMP [inference]

cellular response to cAMP

response to cGMP [inference]

cellular response to cGMP

cellular response to oxygen-containing compound [inference]

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to oxygen-containing compound [inference]

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport

metal ion transport [inference]

potassium ion transport [inference]

potassium ion transmembrane transport

potassium ion import across plasma membrane

sodium ion transport [inference]

sodium ion transmembrane transport

sodium ion import across plasma membrane

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

sodium ion import across plasma membrane

potassium ion transmembrane transport

potassium ion import across plasma membrane

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

sodium ion import across plasma membrane

potassium ion transmembrane transport

potassium ion import across plasma membrane

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

sodium ion import across plasma membrane

potassium ion transmembrane transport

potassium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

import into cell [inference]

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

regulation of membrane depolarization

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of muscle system process [inference]

regulation of muscle contraction [inference]

regulation of striated muscle contraction [inference]

regulation of cardiac muscle contraction

regulation of blood circulation [inference]

regulation of heart contraction

regulation of heart rate

regulation of heart rate by cardiac conduction

regulation of cardiac muscle contraction

cardiac conduction [inference]

regulation of heart rate by cardiac conduction

regulation of action potential [inference]

regulation of cardiac muscle cell action potential [inference]

regulation of cardiac muscle cell action potential involved in regulation of contraction

regulation of biological quality [inference]

regulation of heart rate

regulation of heart rate by cardiac conduction

regulation of membrane potential

action potential [inference]

cardiac muscle cell action potential [inference]

SA node cell action potential

regulation of membrane depolarization

membrane depolarization [inference]

membrane depolarization during action potential [inference]

membrane depolarization during cardiac muscle cell action potential [inference]

membrane depolarization during SA node cell action potential

regulation of action potential [inference]

regulation of cardiac muscle cell action potential [inference]

regulation of cardiac muscle cell action potential involved in regulation of contraction

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GO Term	Evidence Code	Reference
plasma membrane	ISS	GO_REF
plasma membrane	ISO	GO_REF GO_REF
plasma membrane	EXP	PMID
plasma membrane	IEA	GO_REF GO_REF
basolateral plasma membrane	ISO	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

voltage-gated potassium channel complex [inference]

HCN channel complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

potassium channel complex [inference]

voltage-gated potassium channel complex [inference]

HCN channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

potassium channel complex [inference]

voltage-gated potassium channel complex [inference]

HCN channel complex

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

basolateral plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

cell body [inference]

neuronal cell body

perinuclear region of cytoplasm

presynapse [inference]

terminal bouton

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GO Term	Evidence Code	Reference
intracellularly cAMP-activated cation channel activity	ISO	GO_REF
intracellularly cAMP-activated cation channel activity	IMP	PMID
intracellularly cAMP-activated cation channel activity	IEA	GO_REF
voltage-gated sodium channel activity	ISO	GO_REF
voltage-gated sodium channel activity	IEA	GO_REF

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

voltage-gated potassium channel activity involved in SA node cell action potential depolarization

monoatomic cation channel activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

voltage-gated potassium channel activity involved in SA node cell action potential depolarization

sodium channel activity [inference]

voltage-gated sodium channel activity

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

voltage-gated potassium channel activity involved in SA node cell action potential depolarization

ligand-gated monoatomic cation channel activity [inference]

intracellularly cyclic nucleotide-activated monoatomic cation channel activity [inference]

intracellularly cAMP-activated cation channel activity

ligand-gated monoatomic ion channel activity [inference]

intracellularly ligand-gated monoatomic ion channel activity [inference]

intracellularly cyclic nucleotide-activated monoatomic cation channel activity [inference]

intracellularly cAMP-activated cation channel activity

cyclic nucleotide-activated monoatomic ion channel activity [inference]

intracellularly cyclic nucleotide-activated monoatomic cation channel activity [inference]

intracellularly cAMP-activated cation channel activity

ligand-gated monoatomic cation channel activity [inference]

intracellularly cyclic nucleotide-activated monoatomic cation channel activity [inference]

intracellularly cAMP-activated cation channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

voltage-gated potassium channel activity involved in SA node cell action potential depolarization

sodium channel activity [inference]

voltage-gated sodium channel activity

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

voltage-gated potassium channel activity involved in SA node cell action potential depolarization

ligand-gated monoatomic cation channel activity [inference]

intracellularly cyclic nucleotide-activated monoatomic cation channel activity [inference]

intracellularly cAMP-activated cation channel activity

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

voltage-gated potassium channel activity involved in SA node cell action potential depolarization

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

voltage-gated potassium channel activity involved in SA node cell action potential depolarization

monoatomic cation channel activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

voltage-gated potassium channel activity involved in SA node cell action potential depolarization

sodium channel activity [inference]

voltage-gated sodium channel activity

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

voltage-gated potassium channel activity involved in SA node cell action potential depolarization

ligand-gated monoatomic cation channel activity [inference]

intracellularly cyclic nucleotide-activated monoatomic cation channel activity [inference]

intracellularly cAMP-activated cation channel activity

ligand-gated monoatomic ion channel activity [inference]

intracellularly ligand-gated monoatomic ion channel activity [inference]

intracellularly cyclic nucleotide-activated monoatomic cation channel activity [inference]

intracellularly cAMP-activated cation channel activity

cyclic nucleotide-activated monoatomic ion channel activity [inference]

intracellularly cyclic nucleotide-activated monoatomic cation channel activity [inference]

intracellularly cAMP-activated cation channel activity

ligand-gated monoatomic cation channel activity [inference]

intracellularly cyclic nucleotide-activated monoatomic cation channel activity [inference]

intracellularly cAMP-activated cation channel activity

gated channel activity [inference]

voltage-gated channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

voltage-gated potassium channel activity involved in SA node cell action potential depolarization

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

intracellularly ligand-gated monoatomic ion channel activity [inference]

intracellularly cyclic nucleotide-activated monoatomic cation channel activity [inference]

intracellularly cAMP-activated cation channel activity

cyclic nucleotide-activated monoatomic ion channel activity [inference]

intracellularly cyclic nucleotide-activated monoatomic cation channel activity [inference]

intracellularly cAMP-activated cation channel activity

ligand-gated monoatomic cation channel activity [inference]

intracellularly cyclic nucleotide-activated monoatomic cation channel activity [inference]

intracellularly cAMP-activated cation channel activity

binding [inference]

protein binding [inference]

identical protein binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

cAMP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

cyclic nucleotide binding [inference]

cAMP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

cyclic nucleotide binding [inference]

cAMP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MDKLPPSMRKRLYSLPQQVGAKAWIMDEEEDGEEEGAGGRQDPSRRSIRLRPLPSPSPSVAAGCSESRGAALGATESEGPGRSAGKSSTNGDCRRFRGSLASLGSRGGGSGGAGGGSSLGHLHDSAEERRLIAAEGDASPGEDRTPPGLATEPERPATAAQPAASPPPQQPPQPASASCEQPSADTAIKVEGGAAASDQILPEAEVRLGQSGFMQRQFGAMLQPGVNKFSLRMFGSQKAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTTPWIVFNVVSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFVVDFISSIPVDYIFLIVETRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPHDCWVSINGMVNNSWGKQYSYALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQGKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKETKLADGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALDRLDRIGKKNSILLHKVQHDLNSGVFNYQENEIIQQIVRHDREMAHCAHRVQAAASATPTPTPVIWTPLIQAPLQAAAATTSVAIALTHHPRLPAAIFRPPPGPGLGNLGAGQTPRHPRRLQSLIPSALGSASPASSPSQVDTPSSSSFHIQQLAGFSAPPGLSPLLPSSSSSPPPGACGSPPAPTPSTSTAAAASTTGFGHFHKALGGSLSSSDSPLLTPLQPGARSPQAAQPPPPLPGARGGLGLLEHFLPPPPSSRSPSSSPGQLGQPPGELSLGLAAGPSSTPETPPRPERPSFMAGASGGASPVAFTPRGGLSPPGHSPGPPRTFPSAPPRASGSHGSLLLPPASSPPPPQVPQRRGTPPLTPGRLTQDLKLISASQPALPQDGAQTLRRASPHSSGESVAAFSLYPRAGGGSGSSGGLGPPGRPYGAIPGQHVTLPRKTSSGSLPPPLSLFGARAASSGGPPLTTAAPQREPGARSEPVRSKLPSNL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites