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cGMP-specific 3',5'-cyclic phosphodiesterase

Summary

UniProt ID

O76074

Gene Symbol

PDE5
PDE5A

Gene ID

8654

Organism

Homo sapiens (human)

External Links

GlyGen: O76074
PubChem: O76074
The Human Metabolome Database: HMDBP00655
RaftProt: O76074
Re-Glyco: O76074

Annotation

Keyword

3D-structure
Allosteric enzyme
Alternative splicing
Hydrolase
Metal-binding
Phosphoprotein
Reference proteome
Repeat
Zinc
cGMP-binding

Gene Ontology (GO)

Displaying 1 entry
GO Term
cytosol

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 11 in total

1

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GO Term
regulation of nitric oxide mediated signal transduction
positive regulation of oocyte development
cAMP-mediated signaling
relaxation of cardiac muscle
positive regulation of cardiac muscle hypertrophy
positive regulation of MAP kinase activity
cGMP catabolic process
oocyte development
negative regulation of cardiac muscle contraction
T cell proliferation

Displaying **all 7** entries
GO Term
metal ion binding
3',5'-cyclic-nucleotide phosphodiesterase activity
3',5'-cyclic-AMP phosphodiesterase activity
cGMP binding
3',5'-cyclic-GMP phosphodiesterase activity
calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity
calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity

Annotation information from UniProt.

Sequence

MERAGPSFGQQRQQQQPQQQKQQQRDQDSVEAWLDDHWDFTFSYFVRKATREMVNAWFAERVHTIPVCKEGIRGHTESCSCPLQQSPRADNSAPGTPTRKISASEFDRPLRPIVVKDSEGTVSFLSDSEKKEQMPLTPPRFDHDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNCIRLEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKINYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQEKMLINGESGQAKRN

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
137				GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 3** entries
Pathway Name	Organism
RHOBTB1 GTPase cycle	Homo sapiens
Smooth Muscle Contraction	Homo sapiens
cGMP effects	Homo sapiens

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:2986	IgA glomerulonephritis	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements