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Ras-related protein Rab7

Summary

UniProt ID: O76742
Gene Symbol: CG5915 Rab-7 Rab-r7 Rab7 Rab7A
Gene ID: 42841
Organism: Drosophila melanogaster (fruit fly)

External Links

The O-GlcNAc Database: O76742
Re-Glyco: O76742

Annotation

Keyword: Autophagy Cell projection Cytoplasmic vesicle Endosome GTP-binding Hydrolase Lysosome Membrane Phosphoprotein Prenylation Protein transport Reference proteome Synapse

Gene Ontology (GO)

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	Reference
endocytosis	IMP	PMID
phagocytosis	IEP	PMID
border follicle cell migration	IMP	PMID
endosome to lysosome transport	TAS	PMID
endosome to lysosome transport	IMP	PMID

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

small GTPase-mediated signal transduction [inference]

Rab protein signal transduction

intercellular transport [inference]

endosome to lysosome transport

endosome to lysosome transport via multivesicular body sorting pathway

vesicle-mediated transport

exocytosis [inference]

exosomal secretion

endocytosis

receptor-mediated endocytosis [inference]

clathrin-dependent endocytosis [inference]

clathrin-dependent endocytosis involved in vitellogenesis

phagocytosis

endosome to lysosome transport

endosome to lysosome transport via multivesicular body sorting pathway

endosomal transport

endocytic recycling

endosome transport via multivesicular body sorting pathway [inference]

endosome to lysosome transport via multivesicular body sorting pathway

multivesicular body sorting pathway [inference]

endosome transport via multivesicular body sorting pathway [inference]

endosome to lysosome transport via multivesicular body sorting pathway

vesicle-mediated transport to the plasma membrane [inference]

endocytic recycling

cell motility [inference]

cell migration [inference]

ameboidal-type cell migration [inference]

epithelial cell migration [inference]

follicle cell of egg chamber migration [inference]

border follicle cell migration

cellular localization [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport

endosome to lysosome transport via multivesicular body sorting pathway

endosomal transport

endocytic recycling

endosome transport via multivesicular body sorting pathway [inference]

endosome to lysosome transport via multivesicular body sorting pathway

localization within membrane [inference]

vesicle-mediated transport to the plasma membrane [inference]

endocytic recycling

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vesicle organization [inference]

vesicle fusion [inference]

organelle fusion [inference]

organelle membrane fusion [inference]

vesicle fusion [inference]

membrane organization [inference]

T-tubule organization

membrane fusion [inference]

organelle membrane fusion [inference]

vesicle fusion [inference]

export from cell [inference]

secretion by cell [inference]

exocytosis [inference]

exosomal secretion

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

imaginal disc pattern formation [inference]

dorsal/ventral pattern formation, imaginal disc [inference]

wing disc dorsal/ventral pattern formation

wing disc pattern formation [inference]

wing disc dorsal/ventral pattern formation

dorsal/ventral pattern formation [inference]

dorsal/ventral pattern formation, imaginal disc [inference]

wing disc dorsal/ventral pattern formation

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

symbiont entry into host [inference]

symbiont entry into host cell

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein transport

establishment of localization [inference]

transport [inference]

intercellular transport [inference]

endosome to lysosome transport

endosome to lysosome transport via multivesicular body sorting pathway

protein transport

vesicle-mediated transport

exocytosis [inference]

exosomal secretion

endocytosis

receptor-mediated endocytosis [inference]

clathrin-dependent endocytosis [inference]

clathrin-dependent endocytosis involved in vitellogenesis

phagocytosis

endosome to lysosome transport

endosome to lysosome transport via multivesicular body sorting pathway

endosomal transport

endocytic recycling

endosome transport via multivesicular body sorting pathway [inference]

endosome to lysosome transport via multivesicular body sorting pathway

multivesicular body sorting pathway [inference]

endosome transport via multivesicular body sorting pathway [inference]

endosome to lysosome transport via multivesicular body sorting pathway

vesicle-mediated transport to the plasma membrane [inference]

endocytic recycling

secretion [inference]

secretion by cell [inference]

exocytosis [inference]

exosomal secretion

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport

endosome to lysosome transport via multivesicular body sorting pathway

endosomal transport

endocytic recycling

endosome transport via multivesicular body sorting pathway [inference]

endosome to lysosome transport via multivesicular body sorting pathway

import into cell [inference]

endocytosis

receptor-mediated endocytosis [inference]

clathrin-dependent endocytosis [inference]

clathrin-dependent endocytosis involved in vitellogenesis

phagocytosis

export from cell [inference]

secretion by cell [inference]

exocytosis [inference]

exosomal secretion

establishment of protein localization [inference]

protein transport

establishment of localization in cell [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport

endosome to lysosome transport via multivesicular body sorting pathway

endosomal transport

endocytic recycling

endosome transport via multivesicular body sorting pathway [inference]

endosome to lysosome transport via multivesicular body sorting pathway

establishment of vesicle localization [inference]

exosomal secretion

establishment of organelle localization [inference]

establishment of vesicle localization [inference]

exosomal secretion

organelle localization [inference]

vesicle localization [inference]

establishment of vesicle localization [inference]

exosomal secretion

establishment of organelle localization [inference]

establishment of vesicle localization [inference]

exosomal secretion

cellular localization [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport

endosome to lysosome transport via multivesicular body sorting pathway

endosomal transport

endocytic recycling

endosome transport via multivesicular body sorting pathway [inference]

endosome to lysosome transport via multivesicular body sorting pathway

localization within membrane [inference]

vesicle-mediated transport to the plasma membrane [inference]

endocytic recycling

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

small GTPase-mediated signal transduction [inference]

Rab protein signal transduction

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	Reference
autophagosome membrane	IEA	GO_REF
lysosome	IBA	GO_REF
late endosome	IDA	PMID PMID PMID
late endosome	IBA	GO_REF
plasma membrane	HDA	PMID

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytoplasm [inference]

cell cortex

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

bounding membrane of organelle [inference]

vacuolar membrane [inference]

autophagosome membrane

lytic vacuole membrane [inference]

lysosomal membrane [inference]

autolysosome membrane

endosome membrane [inference]

cell junction [inference]

synapse

perikaryon

organelle [inference]

membrane-bounded organelle [inference]

vesicle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

endocytic vesicle [inference]

phagocytic vesicle

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

endocytic vesicle [inference]

phagocytic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

endocytic vesicle [inference]

phagocytic vesicle

cell body [inference]

neuronal cell body

presynapse

Displaying **all 5** entries
GO Term	Evidence Code	Reference
GTPase activity	ISS	GO_REF
GTPase activity	IEA	GO_REF
G protein activity	IEA	GO_REF
GTP binding	IEA	GO_REF
protein-containing complex binding	IPI	PMID

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

GTPase activity

G protein activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

GTP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleoside triphosphate binding [inference]

GTP binding

protein-containing complex binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleoside triphosphate binding [inference]

GTP binding

molecular function regulator activity [inference]

G protein activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MSGRKKSLLKVIILGDSSVGKTSLMNQYVNKRFSNQYKATIGADFCTKEVVVNDRVVTMQIWDTAGQERFQSLGVAFYRGADCCVLVYDVTAPNSFKNLDSWRDEFLIQASPRDPDHFPFVVLGNKVDLDNRQVSTRRAQQWCQSKNDIPYYETSAKEGINVEMAFQVIAKNALELEAEAEVINDFPDQITLGSQNNRPGNPDNCQC

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
47		40245499	G49108TO	The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 9** entries
Pathway Name	Organism
Neutrophil degranulation	Drosophila melanogaster
RAB GEFs exchange GTP for GDP on RABs	Drosophila melanogaster
RAB geranylgeranylation	Drosophila melanogaster
RAC1 GTPase cycle	Drosophila melanogaster
RAC3 GTPase cycle	Drosophila melanogaster
RHOF GTPase cycle	Drosophila melanogaster
RHOH GTPase cycle	Drosophila melanogaster
RHOQ GTPase cycle	Drosophila melanogaster
TBC/RABGAPs	Drosophila melanogaster