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Tumor necrosis factor receptor superfamily member 6

Summary

UniProt ID: O77736
Gene Symbol: APT1 FAS TNFRSF6
Gene ID: 396826
Organism: Sus scrofa (pig)

External Links

PubChem: O77736
Re-Glyco: O77736

Annotation

Keyword: Apoptosis Calmodulin-binding Cell membrane Disulfide bond Glycoprotein Palmitate Phosphoprotein Receptor Reference proteome Repeat Signal Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	Reference
activation-induced cell death of T cells	IBA	GO_REF
immune response	IEA	GO_REF
regulation of stress-activated MAPK cascade	IBA	GO_REF
negative regulation of apoptotic process	IBA	GO_REF
motor neuron apoptotic process	IBA	GO_REF

GO Hierarchy

biological process

immune system process [inference]

immune response

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

extrinsic apoptotic signaling pathway

apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway

necroptotic signaling pathway

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

neuron apoptotic process [inference]

motor neuron apoptotic process

leukocyte apoptotic process [inference]

lymphocyte apoptotic process [inference]

T cell apoptotic process [inference]

activation-induced cell death of T cells

response to stimulus [inference]

immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of stress-activated MAPK cascade

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of stress-activated MAPK cascade

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

extrinsic apoptotic signaling pathway

apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway

necroptotic signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of stress-activated MAPK cascade

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cellular response to stress [inference]

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	Reference
external side of plasma membrane	IBA	GO_REF
CD95 death-inducing signaling complex	IBA	GO_REF
CD95 death-inducing signaling complex	IEA	GO_REF
membrane raft	ISS	GO_REF
membrane raft	IBA	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

death-inducing signaling complex [inference]

CD95 death-inducing signaling complex

cellular anatomical structure [inference]

membrane [inference]

membrane microdomain [inference]

membrane raft

side of membrane [inference]

external side of plasma membrane

Displaying **all 2** entries
GO Term	Evidence Code	Reference
tumor necrosis factor receptor activity	IBA	GO_REF
calmodulin binding	ISS	GO_REF

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

calmodulin binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

death receptor activity [inference]

tumor necrosis factor receptor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MSGIWVLLSLVFTCIAGPLSKGDDAQVTDPDSEMVKLNITKRESECPEGQHREGQFCCQPCPPGKRKHADCTSPGGAPQCVPCSEGEDYTDKNHHSSKCRRCRVCDGEHGLEVEKNCTRTQNTKCRCKPNFFCHTSQCEHCNPCTTCEHGVIENCTPTSNTKCREVFQSAGSRSNLHWLWALLILIPVPALVYREVKRRCRRKENGYQKPITSNAEEVPMIKDVDLGKYITRIAEQMKITEVKDFVRKNGIEETKIDEIMHDNPKDTAEQKVQLLRNWYLYHGKKDAYCTLIQGLRKAKLSALADKINDIVQKDVTSEQENANSQNENESLT

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
38	N-linked (GlcNAc...) asparagine			UniProt
116	N-linked (GlcNAc...) asparagine			UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
CASP8 activity is inhibited	Sus scrofa
Dimerization of procaspase-8	Sus scrofa
FasL/ CD95L signaling	Sus scrofa
Regulation by c-FLIP	Sus scrofa

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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External Links

Annotation

International Collaboration

Acknowledgements