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WD repeat-containing protein 1

Summary

UniProt ID: O88342
Gene Symbol: Wdr1
Gene ID: 22388
Organism: Mus musculus (house mouse)

External Links

GlyGen: O88342
Re-Glyco: O88342

Annotation

Keyword: Acetylation Actin-binding Cell junction Cell projection Cytoskeleton Direct protein sequencing Phosphoprotein Reference proteome Repeat WD repeat

Gene Ontology (GO)

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	Reference
neutrophil mediated immunity	IMP	PMID
sensory perception of sound	ISO	PMID
regulation of cell shape
actin cytoskeleton organization	IMP	PMID
actin filament depolymerization

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

leukocyte mediated immunity [inference]

myeloid leukocyte mediated immunity [inference]

neutrophil mediated immunity

leukocyte migration [inference]

myeloid leukocyte migration [inference]

granulocyte migration [inference]

neutrophil migration

cellular process [inference]

establishment or maintenance of cell polarity [inference]

establishment or maintenance of polarity of follicular epithelium [inference]

establishment of planar polarity of follicular epithelium

maintenance of cell polarity [inference]

maintenance of apical/basal cell polarity [inference]

maintenance of epithelial cell apical/basal polarity

establishment or maintenance of bipolar cell polarity [inference]

establishment or maintenance of apical/basal cell polarity [inference]

maintenance of apical/basal cell polarity [inference]

maintenance of epithelial cell apical/basal polarity

establishment or maintenance of epithelial cell apical/basal polarity [inference]

maintenance of epithelial cell apical/basal polarity

actin filament-based process [inference]

actin cytoskeleton organization

actomyosin structure organization [inference]

sarcomere organization

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation [inference]

platelet formation

cell motility [inference]

cell migration [inference]

leukocyte migration [inference]

myeloid leukocyte migration [inference]

granulocyte migration [inference]

neutrophil migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization

actomyosin structure organization [inference]

sarcomere organization

cortical cytoskeleton organization

cellular component disassembly [inference]

protein-containing complex disassembly [inference]

protein depolymerization [inference]

actin filament depolymerization

actin filament fragmentation

cellular component assembly [inference]

cell junction assembly [inference]

cell-cell junction assembly [inference]

apical junction assembly

regulation of cellular component size [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament depolymerization

positive regulation of actin filament depolymerization

cell junction organization [inference]

cell junction assembly [inference]

cell-cell junction assembly [inference]

apical junction assembly

cell-cell junction organization [inference]

cell-cell junction assembly [inference]

apical junction assembly

protein-containing complex organization [inference]

protein-containing complex disassembly [inference]

protein depolymerization [inference]

actin filament depolymerization

actin filament fragmentation

supramolecular fiber organization [inference]

actin filament organization [inference]

actin polymerization or depolymerization [inference]

actin filament depolymerization

actin filament fragmentation

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of mechanical stimulus [inference]

sensory perception of sound

developmental process [inference]

anatomical structure morphogenesis [inference]

establishment of tissue polarity [inference]

establishment of planar polarity [inference]

establishment of planar polarity of follicular epithelium

anatomical structure formation involved in morphogenesis [inference]

platelet formation

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation [inference]

platelet formation

locomotion

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament depolymerization

positive regulation of protein-containing complex disassembly [inference]

positive regulation of protein depolymerization [inference]

positive regulation of actin filament depolymerization

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin filament depolymerization

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of cell morphogenesis [inference]

regulation of cell shape

regulation of cell differentiation [inference]

regulation of glial cell differentiation [inference]

regulation of oligodendrocyte differentiation

regulation of cellular process [inference]

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament depolymerization

positive regulation of actin filament depolymerization

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament depolymerization

positive regulation of actin filament depolymerization

regulation of cell differentiation [inference]

regulation of glial cell differentiation [inference]

regulation of oligodendrocyte differentiation

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament depolymerization

positive regulation of protein-containing complex disassembly [inference]

positive regulation of protein depolymerization [inference]

positive regulation of actin filament depolymerization

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin filament depolymerization

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament depolymerization

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament depolymerization

positive regulation of actin filament depolymerization

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament depolymerization

positive regulation of actin filament depolymerization

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament depolymerization

regulation of protein-containing complex disassembly [inference]

positive regulation of protein-containing complex disassembly [inference]

positive regulation of protein depolymerization [inference]

positive regulation of actin filament depolymerization

regulation of protein depolymerization [inference]

regulation of actin filament depolymerization

positive regulation of actin filament depolymerization

positive regulation of protein depolymerization [inference]

positive regulation of actin filament depolymerization

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament depolymerization

positive regulation of protein-containing complex disassembly [inference]

positive regulation of protein depolymerization [inference]

positive regulation of actin filament depolymerization

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin filament depolymerization

regulation of supramolecular fiber organization [inference]

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament depolymerization

positive regulation of actin filament depolymerization

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin filament depolymerization

regulation of membrane repolarization [inference]

regulation of cardiac muscle cell membrane repolarization [inference]

regulation of ventricular cardiac muscle cell membrane repolarization

regulation of biological quality [inference]

regulation of cell shape

regulation of membrane potential [inference]

regulation of membrane repolarization [inference]

regulation of cardiac muscle cell membrane repolarization [inference]

regulation of ventricular cardiac muscle cell membrane repolarization

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament depolymerization

positive regulation of actin filament depolymerization

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	Reference
podosome	IEA	GO_REF
cytosol	ISO	GO_REF
cytosol	IEA	GO_REF
plasma membrane	ISO	GO_REF
cell-cell junction	ISO	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytosol

membrane [inference]

plasma membrane

cell junction

synapse

glutamatergic synapse

anchoring junction [inference]

cell-cell junction

myelin sheath

organelle [inference]

membraneless organelle [inference]

intracellular membraneless organelle [inference]

podosome

cytoskeleton [inference]

actin cytoskeleton

cortical cytoskeleton [inference]

cortical actin cytoskeleton

intracellular organelle [inference]

intracellular membraneless organelle [inference]

podosome

cytoskeleton [inference]

actin cytoskeleton

cortical cytoskeleton [inference]

cortical actin cytoskeleton

Displaying **all 4** entries
GO Term	Evidence Code	Reference
actin binding	ISO	PMID
actin filament binding	ISS	GO_REF
actin filament binding	ISO	PMID
actin filament binding	IEA	GO_REF

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

cytoskeletal protein binding [inference]

actin binding

actin filament binding

protein-containing complex binding [inference]

actin filament binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MPYEIKKVFASLPQVERGVSKILGGDPKGDHFLYTNGKCVILRNIDNPAIADIYTEHAHQVVVAKYAPSGFYIASGDISGKLRIWDTTQKEHLLKYEYQPFAGKIKDIAWTEDSKRIAVVGEGREKFGAVFLWDTGSSVGEITGHNKVINSVDIKQTRPYRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIFIYDGKTGEKVCALGESKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVNVNSVVSTFPMGSNVLDQQLGCLWQKDHLLSISLSGYINYLDKNNPSKPLRVIKGHSKSIQCLTVHRNGGKSYIYSGSHDGHINYWDSETGENDSFSGKGHTNQVSRMTVNESEQLVSCSMDDTVRYTNLTLRDYSGQGVVKLDVQPKCVAVGPGGYTVVVCIGQIVLLKDQKKCFSIDNPGYEPEVVAVHPGGDTVAVGGTDGNVRVYSILASTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETKVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVKEWTITY

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites