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Isocitrate dehydrogenase [NADP] cytoplasmic

Summary

UniProt ID: O88844
Gene Symbol: Idh1
Gene ID: 15926
Organism: Mus musculus (house mouse)

External Links

GlyGen: O88844
PubChem: O88844
Re-Glyco: O88844

Annotation

Keyword: 3D-structure Acetylation Cytoplasm Direct protein sequencing Glyoxylate bypass Magnesium Manganese Metal-binding NADP Oxidoreductase Phosphoprotein Reference proteome Tricarboxylic acid cycle

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	Reference
glyoxylate cycle
tricarboxylic acid cycle	IBA	GO_REF
isocitrate metabolic process	ISS	GO_REF
isocitrate metabolic process	ISO	GO_REF GO_REF
isocitrate metabolic process	IEA	GO_REF GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

aldehyde metabolic process [inference]

glyoxylate metabolic process [inference]

glyoxylate cycle

generation of precursor metabolites and energy [inference]

NADPH regeneration

modified amino acid metabolic process [inference]

glutathione metabolic process

sulfur compound metabolic process [inference]

glutathione metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP+ metabolic process

NADPH regeneration

nicotinamide nucleotide metabolic process [inference]

NADP+ metabolic process

NADPH regeneration

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP+ metabolic process

NADPH regeneration

nicotinamide nucleotide metabolic process [inference]

NADP+ metabolic process

NADPH regeneration

primary metabolic process [inference]

carbohydrate metabolic process [inference]

glyoxylate cycle

tricarboxylic acid cycle

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP+ metabolic process

NADPH regeneration

nicotinamide nucleotide metabolic process [inference]

NADP+ metabolic process

NADPH regeneration

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

isocitrate metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

glyoxylate metabolic process [inference]

glyoxylate cycle

dicarboxylic acid metabolic process [inference]

2-oxoglutarate metabolic process

tricarboxylic acid metabolic process [inference]

isocitrate metabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP+ metabolic process

NADPH regeneration

nicotinamide nucleotide metabolic process [inference]

NADP+ metabolic process

NADPH regeneration

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP+ metabolic process

NADPH regeneration

pyridine-containing compound metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP+ metabolic process

NADPH regeneration

reproductive process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

female gonad development

developmental process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

female gonad development

anatomical structure development [inference]

animal organ development [inference]

gonad development [inference]

female gonad development

reproductive structure development [inference]

gonad development [inference]

female gonad development

response to stimulus [inference]

response to stress [inference]

response to oxidative stress

response to endogenous stimulus [inference]

response to hormone [inference]

response to steroid hormone

response to chemical [inference]

response to hormone [inference]

response to steroid hormone

response to lipid [inference]

response to steroid hormone

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of lipid biosynthetic process [inference]

regulation of phospholipid biosynthetic process

regulation of catabolic process [inference]

regulation of lipid catabolic process [inference]

regulation of phospholipid catabolic process

regulation of phosphorus metabolic process [inference]

regulation of phospholipid metabolic process [inference]

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of lipid biosynthetic process [inference]

regulation of phospholipid biosynthetic process

regulation of lipid catabolic process [inference]

regulation of phospholipid catabolic process

regulation of phospholipid metabolic process [inference]

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	Reference
cytoplasm	ISO	GO_REF
cytoplasm	IEA	GO_REF
mitochondrion	IDA	PMID
mitochondrion	IBA	GO_REF
mitochondrion	HDA	PMID

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

microbody lumen [inference]

peroxisomal matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

microbody [inference]

peroxisome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

microbody [inference]

peroxisome

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	Reference
magnesium ion binding	ISS	GO_REF
magnesium ion binding	ISO	GO_REF
magnesium ion binding	IEA	GO_REF GO_REF
isocitrate dehydrogenase (NADP+) activity	ISS	GO_REF
isocitrate dehydrogenase (NADP+) activity	ISO	GO_REF GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

isocitrate dehydrogenase [NAD(P)+] activity [inference]

isocitrate dehydrogenase (NADP+) activity

binding [inference]

protein binding [inference]

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

magnesium ion binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MSRKIQGGSVVEMQGDEMTRIIWELIKEKLILPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPKDGTQKVTYMVHDFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKKYKSQFEAQKICYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWSRGLAHRAKLDNNTELSFFAKALEDVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKLAQAKL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites