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Synapsin-1

Summary

UniProt ID: O88935
Gene Symbol: Syn-1 Syn1
Gene ID: 20964
Organism: Mus musculus (house mouse)

External Links

GlyGen: O88935
PubChem: O88935
The O-GlcNAc Database: O88935
O-GlcNAcAtlas: O88935
Re-Glyco: O88935

Annotation

Keyword: Actin-binding Alternative splicing Cell projection Cytoplasmic vesicle Direct protein sequencing Glycoprotein Golgi apparatus Methylation Phosphoprotein Reference proteome Repeat Synapse

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	Reference
neurotransmitter secretion	IMP	PMID
neurotransmitter secretion	IGI	PMID
neurotransmitter secretion	IEA	GO_REF
regulation of short-term neuronal synaptic plasticity	TAS	PMID
neuron development	IEA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

vesicle-mediated transport [inference]

vesicle-mediated transport in synapse [inference]

synaptic vesicle cycle

cellular developmental process [inference]

cell development [inference]

neuron development

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell junction organization [inference]

synapse organization

export from cell [inference]

secretion by cell [inference]

signal release [inference]

signal release from synapse [inference]

neurotransmitter secretion

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

neuron development

cellular developmental process [inference]

cell development [inference]

neuron development

localization [inference]

establishment of localization [inference]

transport [inference]

neurotransmitter transport [inference]

neurotransmitter secretion

vesicle-mediated transport [inference]

vesicle-mediated transport in synapse [inference]

synaptic vesicle cycle

secretion [inference]

secretion by cell [inference]

signal release [inference]

signal release from synapse [inference]

neurotransmitter secretion

export from cell [inference]

secretion by cell [inference]

signal release [inference]

signal release from synapse [inference]

neurotransmitter secretion

establishment of localization in cell [inference]

organelle localization [inference]

vesicle localization [inference]

synaptic vesicle localization [inference]

synaptic vesicle clustering

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity [inference]

regulation of short-term neuronal synaptic plasticity

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of synaptic vesicle exocytosis

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis

regulation of neurotransmitter transport [inference]

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of synaptic vesicle exocytosis

regulation of synaptic vesicle cycle

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity [inference]

regulation of short-term neuronal synaptic plasticity

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of synaptic vesicle exocytosis

regulation of synaptic vesicle cycle

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of synaptic vesicle exocytosis

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis

regulation of biological quality [inference]

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity [inference]

regulation of short-term neuronal synaptic plasticity

Displaying entries **1 - 5** of 31 in total

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GO Term	Evidence Code	Reference
synaptonemal complex	IDA	PMID
Golgi apparatus	IEA	GO_REF
cytoskeleton	ISO	GO_REF
cytoskeleton	IEA	GO_REF
synaptic vesicle	ISO	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane [inference]

clathrin-sculpted glutamate transport vesicle membrane

exocytic vesicle membrane [inference]

synaptic vesicle membrane

coated vesicle membrane [inference]

clathrin-coated vesicle membrane [inference]

clathrin-sculpted glutamate transport vesicle membrane

bounding membrane of organelle [inference]

transport vesicle membrane [inference]

clathrin-sculpted glutamate transport vesicle membrane

exocytic vesicle membrane [inference]

synaptic vesicle membrane

coated vesicle membrane [inference]

clathrin-coated vesicle membrane [inference]

clathrin-sculpted glutamate transport vesicle membrane

extrinsic component of membrane [inference]

extrinsic component of organelle membrane [inference]

extrinsic component of synaptic vesicle membrane

cell junction [inference]

synapse

Schaffer collateral - CA1 synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

myelin sheath

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

membraneless organelle [inference]

intracellular membraneless organelle [inference]

cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular membraneless organelle [inference]

cytoskeleton

postsynaptic specialization [inference]

postsynaptic density

synaptonemal structure [inference]

synaptonemal complex

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	Reference
actin binding
ATP binding	IEA	GO_REF
protein kinase binding	IPI	PMID
identical protein binding	IPI	PMID
calcium-dependent protein binding	ISO	GO_REF

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

cytoskeletal protein binding [inference]

actin binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MNYLRRRLSDSNFMANLPNGYMTDLQRPQPPPPPPSAASPGATPGSATASAERASTAAPVASPAAPSPGSSGGGGFFSSLSNAVKQTTAAAAATFSEQVGGGSGGAGRGGAAARVLLVIDEPHTDWAKYFKGKKIHGEIDIKVEQAEFSDLNLVAHANGGFSVDMEVLRNGVKVVRSLKPDFVLIRQHAFSMARNGDYRSLVIGLQYAGIPSVNSLHSVYNFCDKPWVFAQMVRLHKKLGTEEFPLIDQTFYPNHKEMLSSTTYPVVVKMGHAHSGMGKVKVDNQHDFQDIASVVALTKTYATAEPFIDAKYDVRVQKIGQNYKAYMRTSVSGNWKTNTGSAMLEQIAMSDRYKLWVDTCSEIFGGLDICAVEALHGKDGRDHIIEVVGSSMPLIGDHQDEDKQLIVELVVNKMTQALPRQPQRDASPGRGSHSQSSSPGALTLGRQTSQQPAGPPAQQRPPPQGGPPQPGPGPQRQGPPLQQRPPPQGQQHLSGLGPPAGSPLPQRLPSPTAAPQQSASQATPVTQGQGRQSRPVAGGPGAPPAARPPASPSPQRQAGAPQATRQASISGPAPTKASGAPPGGQQRQGPPQKPPGPAGPTRQASQAGPGPRTGPPTTQQPRPSGPGPAGRPAKPQLAQKPSQDVPPPITAAAGGPPHPQLNKSQSLTNAFNLPEPAPPRPSLSQDEVKAETIRSLRKSFASLFSD

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **1 - 10** of 39 in total

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Position	Description	PubMed ID	GlyTouCan ID	Source
36		16452088 22826440 24280219 34678516 35822049 40021952 40885482	G49108TO	The O-GlcNAc Database
39		16452088 22826440 24280219 34678516 35822049 40021952 40885482	G49108TO	The O-GlcNAc Database
43				GlyGen
46		16452088 22826440 24280219 34678516 35822049 40021952 40885482	G49108TO	GlyGen The O-GlcNAc Database
48		16452088 22826440 24280219 34678516 35822049 40021952 40885482	G49108TO	The O-GlcNAc Database
55	O-linked (GlcNAc) serine	16452088 22826440 24280219 34678516 35822049 40021952 40885482	G49108TO	UniProt GlyGen The O-GlcNAc Database
56	O-linked (GlcNAc) threonine	16452088 22826440 24280219 34678516 35822049 40021952 40885482	G49108TO	UniProt GlyGen The O-GlcNAc Database
62			G49108TO	GlyGen
67		16452088 22826440 24280219 34678516 35822049 40021952 40885482	G49108TO	The O-GlcNAc Database
71		16452088 22826440 24280219 34678516 35822049 40021952 40885482	G49108TO	The O-GlcNAc Database