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Alpha-actinin-3

Summary

UniProt ID: O88990
Gene Symbol: Actn3
Gene ID: 11474
Organism: Mus musculus (house mouse)

External Links

GlyGen: O88990
The O-GlcNAc Database: O88990
O-GlcNAcAtlas: O88990
Re-Glyco: O88990

Annotation

Keyword: Acetylation Actin-binding Calcium Metal-binding Reference proteome Repeat

Gene Ontology (GO)

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	Reference
muscle contraction	TAS	PMID
regulation of the force of skeletal muscle contraction	IMP	PMID
skeletal muscle atrophy	IMP	PMID
transition between fast and slow fiber	IMP	PMID
response to denervation involved in regulation of muscle adaptation	IMP	PMID

GO Hierarchy

biological process

cellular process [inference]

actin filament-based process [inference]

actin cytoskeleton organization

cellular developmental process [inference]

cell development [inference]

muscle cell development

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization

cellular component assembly [inference]

cell junction assembly [inference]

cell-substrate junction assembly [inference]

focal adhesion assembly

cell junction organization [inference]

cell junction assembly [inference]

cell-substrate junction assembly [inference]

focal adhesion assembly

cell-substrate junction organization [inference]

cell-substrate junction assembly [inference]

focal adhesion assembly

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction

muscle adaptation [inference]

striated muscle adaptation [inference]

striated muscle atrophy [inference]

skeletal muscle atrophy

skeletal muscle adaptation [inference]

skeletal muscle atrophy

muscle atrophy [inference]

striated muscle atrophy [inference]

skeletal muscle atrophy

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

bone morphogenesis

anatomical structure development [inference]

cell development [inference]

muscle cell development

cellular developmental process [inference]

cell development [inference]

muscle cell development

response to stimulus [inference]

response to inactivity [inference]

response to muscle inactivity [inference]

response to denervation involved in regulation of muscle adaptation

muscle adaptation [inference]

striated muscle adaptation [inference]

striated muscle atrophy [inference]

skeletal muscle atrophy

skeletal muscle adaptation [inference]

skeletal muscle atrophy

muscle atrophy [inference]

striated muscle atrophy [inference]

skeletal muscle atrophy

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling [inference]

negative regulation of calcineurin-mediated signaling [inference]

negative regulation of calcineurin-NFAT signaling cascade

regulation of intracellular signal transduction [inference]

regulation of calcium-mediated signaling [inference]

negative regulation of calcium-mediated signaling [inference]

negative regulation of calcineurin-mediated signaling [inference]

negative regulation of calcineurin-NFAT signaling cascade

regulation of calcineurin-mediated signaling [inference]

regulation of calcineurin-NFAT signaling cascade [inference]

negative regulation of calcineurin-NFAT signaling cascade

negative regulation of calcineurin-mediated signaling [inference]

negative regulation of calcineurin-NFAT signaling cascade

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling [inference]

negative regulation of calcineurin-mediated signaling [inference]

negative regulation of calcineurin-NFAT signaling cascade

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling [inference]

negative regulation of calcineurin-mediated signaling [inference]

negative regulation of calcineurin-NFAT signaling cascade

regulation of growth [inference]

positive regulation of growth [inference]

positive regulation of developmental growth [inference]

positive regulation of skeletal muscle tissue growth

regulation of developmental growth [inference]

regulation of skeletal muscle tissue growth [inference]

positive regulation of skeletal muscle tissue growth

positive regulation of developmental growth [inference]

positive regulation of skeletal muscle tissue growth

positive regulation of biological process [inference]

positive regulation of growth [inference]

positive regulation of developmental growth [inference]

positive regulation of skeletal muscle tissue growth

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of glucose catabolic process to lactate via pyruvate

positive regulation of small molecule metabolic process [inference]

positive regulation of glucose catabolic process to lactate via pyruvate

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of skeletal muscle fiber development

positive regulation of muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of skeletal muscle fiber development

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of skeletal muscle fiber development

positive regulation of muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of skeletal muscle fiber development

positive regulation of muscle organ development [inference]

positive regulation of striated muscle tissue development [inference]

positive regulation of skeletal muscle tissue development [inference]

positive regulation of developmental growth [inference]

positive regulation of skeletal muscle tissue growth

positive regulation of biomineral tissue development [inference]

positive regulation of bone mineralization [inference]

positive regulation of bone mineralization involved in bone maturation

positive regulation of muscle tissue development [inference]

positive regulation of striated muscle tissue development [inference]

positive regulation of skeletal muscle tissue development [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of ossification [inference]

positive regulation of bone mineralization [inference]

positive regulation of bone mineralization involved in bone maturation

positive regulation of muscle contraction [inference]

positive regulation of striated muscle contraction [inference]

positive regulation of fast-twitch skeletal muscle fiber contraction

positive regulation of muscle organ development [inference]

positive regulation of striated muscle tissue development [inference]

positive regulation of skeletal muscle tissue development [inference]

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling [inference]

negative regulation of calcineurin-mediated signaling [inference]

negative regulation of calcineurin-NFAT signaling cascade

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of nucleotide catabolic process [inference]

negative regulation of purine nucleotide catabolic process [inference]

negative regulation of glycolytic process

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of nucleotide metabolic process [inference]

negative regulation of nucleotide catabolic process [inference]

negative regulation of purine nucleotide catabolic process [inference]

negative regulation of glycolytic process

negative regulation of purine nucleotide metabolic process [inference]

negative regulation of purine nucleotide catabolic process [inference]

negative regulation of glycolytic process

negative regulation of ATP metabolic process [inference]

negative regulation of glycolytic process

negative regulation of carbohydrate metabolic process [inference]

negative regulation of glycolytic process

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleotide metabolic process [inference]

negative regulation of nucleotide catabolic process [inference]

negative regulation of purine nucleotide catabolic process [inference]

negative regulation of glycolytic process

negative regulation of purine nucleotide metabolic process [inference]

negative regulation of purine nucleotide catabolic process [inference]

negative regulation of glycolytic process

negative regulation of ATP metabolic process [inference]

negative regulation of glycolytic process

negative regulation of small molecule metabolic process [inference]

negative regulation of nucleotide metabolic process [inference]

negative regulation of nucleotide catabolic process [inference]

negative regulation of purine nucleotide catabolic process [inference]

negative regulation of glycolytic process

negative regulation of purine nucleotide metabolic process [inference]

negative regulation of purine nucleotide catabolic process [inference]

negative regulation of glycolytic process

negative regulation of ATP metabolic process [inference]

negative regulation of glycolytic process

negative regulation of cellular respiration [inference]

negative regulation of oxidative phosphorylation

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling [inference]

negative regulation of calcineurin-mediated signaling [inference]

negative regulation of calcineurin-NFAT signaling cascade

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling [inference]

negative regulation of calcineurin-mediated signaling [inference]

negative regulation of calcineurin-NFAT signaling cascade

negative regulation of multicellular organismal process [inference]

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling [inference]

negative regulation of calcineurin-mediated signaling [inference]

negative regulation of calcineurin-NFAT signaling cascade

regulation of intracellular signal transduction [inference]

regulation of calcium-mediated signaling [inference]

negative regulation of calcium-mediated signaling [inference]

negative regulation of calcineurin-mediated signaling [inference]

negative regulation of calcineurin-NFAT signaling cascade

regulation of calcineurin-mediated signaling [inference]

regulation of calcineurin-NFAT signaling cascade [inference]

negative regulation of calcineurin-NFAT signaling cascade

negative regulation of calcineurin-mediated signaling [inference]

negative regulation of calcineurin-NFAT signaling cascade

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling [inference]

negative regulation of calcineurin-mediated signaling [inference]

negative regulation of calcineurin-NFAT signaling cascade

regulation of muscle adaptation [inference]

regulation of skeletal muscle adaptation [inference]

transition between fast and slow fiber

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling [inference]

negative regulation of calcineurin-mediated signaling [inference]

negative regulation of calcineurin-NFAT signaling cascade

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of skeletal muscle fiber development

positive regulation of muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of skeletal muscle fiber development

regulation of muscle cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of skeletal muscle fiber development

regulation of striated muscle cell differentiation [inference]

regulation of myotube differentiation [inference]

regulation of skeletal muscle fiber development [inference]

positive regulation of skeletal muscle fiber development

positive regulation of striated muscle cell differentiation [inference]

positive regulation of skeletal muscle fiber development

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of skeletal muscle fiber development

regulation of skeletal muscle fiber development [inference]

positive regulation of skeletal muscle fiber development

regulation of muscle organ development [inference]

regulation of striated muscle tissue development [inference]

positive regulation of striated muscle tissue development [inference]

positive regulation of skeletal muscle tissue development [inference]

regulation of skeletal muscle tissue development [inference]

positive regulation of skeletal muscle tissue development [inference]

positive regulation of muscle organ development [inference]

positive regulation of striated muscle tissue development [inference]

positive regulation of skeletal muscle tissue development [inference]

regulation of developmental growth [inference]

regulation of skeletal muscle tissue growth [inference]

positive regulation of skeletal muscle tissue growth

positive regulation of developmental growth [inference]

positive regulation of skeletal muscle tissue growth

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of skeletal muscle fiber development

positive regulation of muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of skeletal muscle fiber development

positive regulation of muscle organ development [inference]

positive regulation of striated muscle tissue development [inference]

positive regulation of skeletal muscle tissue development [inference]

positive regulation of developmental growth [inference]

positive regulation of skeletal muscle tissue growth

positive regulation of biomineral tissue development [inference]

positive regulation of bone mineralization [inference]

positive regulation of bone mineralization involved in bone maturation

positive regulation of muscle tissue development [inference]

positive regulation of striated muscle tissue development [inference]

positive regulation of skeletal muscle tissue development [inference]

regulation of muscle tissue development [inference]

regulation of striated muscle tissue development [inference]

positive regulation of striated muscle tissue development [inference]

positive regulation of skeletal muscle tissue development [inference]

regulation of skeletal muscle tissue development [inference]

positive regulation of skeletal muscle tissue development [inference]

positive regulation of muscle tissue development [inference]

positive regulation of striated muscle tissue development [inference]

positive regulation of skeletal muscle tissue development [inference]

regulation of multicellular organismal development [inference]

regulation of biomineral tissue development [inference]

regulation of bone mineralization [inference]

positive regulation of bone mineralization [inference]

positive regulation of bone mineralization involved in bone maturation

positive regulation of biomineral tissue development [inference]

positive regulation of bone mineralization [inference]

positive regulation of bone mineralization involved in bone maturation

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling [inference]

negative regulation of calcineurin-mediated signaling [inference]

negative regulation of calcineurin-NFAT signaling cascade

regulation of intracellular signal transduction [inference]

regulation of calcium-mediated signaling [inference]

negative regulation of calcium-mediated signaling [inference]

negative regulation of calcineurin-mediated signaling [inference]

negative regulation of calcineurin-NFAT signaling cascade

regulation of calcineurin-mediated signaling [inference]

regulation of calcineurin-NFAT signaling cascade [inference]

negative regulation of calcineurin-NFAT signaling cascade

negative regulation of calcineurin-mediated signaling [inference]

negative regulation of calcineurin-NFAT signaling cascade

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling [inference]

negative regulation of calcineurin-mediated signaling [inference]

negative regulation of calcineurin-NFAT signaling cascade

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling [inference]

negative regulation of calcineurin-mediated signaling [inference]

negative regulation of calcineurin-NFAT signaling cascade

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of nucleotide catabolic process [inference]

negative regulation of purine nucleotide catabolic process [inference]

negative regulation of glycolytic process

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of nucleotide metabolic process [inference]

negative regulation of nucleotide catabolic process [inference]

negative regulation of purine nucleotide catabolic process [inference]

negative regulation of glycolytic process

negative regulation of purine nucleotide metabolic process [inference]

negative regulation of purine nucleotide catabolic process [inference]

negative regulation of glycolytic process

negative regulation of ATP metabolic process [inference]

negative regulation of glycolytic process

negative regulation of carbohydrate metabolic process [inference]

negative regulation of glycolytic process

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleotide metabolic process [inference]

negative regulation of nucleotide catabolic process [inference]

negative regulation of purine nucleotide catabolic process [inference]

negative regulation of glycolytic process

negative regulation of purine nucleotide metabolic process [inference]

negative regulation of purine nucleotide catabolic process [inference]

negative regulation of glycolytic process

negative regulation of ATP metabolic process [inference]

negative regulation of glycolytic process

negative regulation of small molecule metabolic process [inference]

negative regulation of nucleotide metabolic process [inference]

negative regulation of nucleotide catabolic process [inference]

negative regulation of purine nucleotide catabolic process [inference]

negative regulation of glycolytic process

negative regulation of purine nucleotide metabolic process [inference]

negative regulation of purine nucleotide catabolic process [inference]

negative regulation of glycolytic process

negative regulation of ATP metabolic process [inference]

negative regulation of glycolytic process

negative regulation of cellular respiration [inference]

negative regulation of oxidative phosphorylation

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of glucose catabolic process to lactate via pyruvate

positive regulation of small molecule metabolic process [inference]

positive regulation of glucose catabolic process to lactate via pyruvate

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of nucleotide catabolic process [inference]

negative regulation of purine nucleotide catabolic process [inference]

negative regulation of glycolytic process

positive regulation of catabolic process [inference]

positive regulation of glucose catabolic process to lactate via pyruvate

regulation of nucleotide catabolic process [inference]

negative regulation of nucleotide catabolic process [inference]

negative regulation of purine nucleotide catabolic process [inference]

negative regulation of glycolytic process

regulation of purine nucleotide catabolic process [inference]

regulation of glycolytic process [inference]

negative regulation of glycolytic process

negative regulation of purine nucleotide catabolic process [inference]

negative regulation of glycolytic process

regulation of carbohydrate catabolic process [inference]

regulation of glycolytic process [inference]

negative regulation of glycolytic process

regulation of glucose catabolic process to lactate via pyruvate [inference]

positive regulation of glucose catabolic process to lactate via pyruvate

regulation of generation of precursor metabolites and energy [inference]

regulation of glycolytic process [inference]

negative regulation of glycolytic process

regulation of cellular respiration [inference]

negative regulation of cellular respiration [inference]

negative regulation of oxidative phosphorylation

regulation of aerobic respiration

regulation of oxidative phosphorylation [inference]

negative regulation of oxidative phosphorylation

regulation of fermentation [inference]

regulation of glucose catabolic process to lactate via pyruvate [inference]

positive regulation of glucose catabolic process to lactate via pyruvate

regulation of phosphorus metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide catabolic process [inference]

negative regulation of nucleotide catabolic process [inference]

negative regulation of purine nucleotide catabolic process [inference]

negative regulation of glycolytic process

regulation of purine nucleotide catabolic process [inference]

regulation of glycolytic process [inference]

negative regulation of glycolytic process

negative regulation of purine nucleotide catabolic process [inference]

negative regulation of glycolytic process

negative regulation of nucleotide metabolic process [inference]

negative regulation of nucleotide catabolic process [inference]

negative regulation of purine nucleotide catabolic process [inference]

negative regulation of glycolytic process

negative regulation of purine nucleotide metabolic process [inference]

negative regulation of purine nucleotide catabolic process [inference]

negative regulation of glycolytic process

negative regulation of ATP metabolic process [inference]

negative regulation of glycolytic process

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide catabolic process [inference]

regulation of glycolytic process [inference]

negative regulation of glycolytic process

negative regulation of purine nucleotide catabolic process [inference]

negative regulation of glycolytic process

negative regulation of purine nucleotide metabolic process [inference]

negative regulation of purine nucleotide catabolic process [inference]

negative regulation of glycolytic process

negative regulation of ATP metabolic process [inference]

negative regulation of glycolytic process

regulation of ATP metabolic process [inference]

regulation of glycolytic process [inference]

negative regulation of glycolytic process

negative regulation of ATP metabolic process [inference]

negative regulation of glycolytic process

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of nucleotide metabolic process [inference]

negative regulation of nucleotide catabolic process [inference]

negative regulation of purine nucleotide catabolic process [inference]

negative regulation of glycolytic process

negative regulation of purine nucleotide metabolic process [inference]

negative regulation of purine nucleotide catabolic process [inference]

negative regulation of glycolytic process

negative regulation of ATP metabolic process [inference]

negative regulation of glycolytic process

regulation of small molecule metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide catabolic process [inference]

negative regulation of nucleotide catabolic process [inference]

negative regulation of purine nucleotide catabolic process [inference]

negative regulation of glycolytic process

regulation of purine nucleotide catabolic process [inference]

regulation of glycolytic process [inference]

negative regulation of glycolytic process

negative regulation of purine nucleotide catabolic process [inference]

negative regulation of glycolytic process

negative regulation of nucleotide metabolic process [inference]

negative regulation of nucleotide catabolic process [inference]

negative regulation of purine nucleotide catabolic process [inference]

negative regulation of glycolytic process

negative regulation of purine nucleotide metabolic process [inference]

negative regulation of purine nucleotide catabolic process [inference]

negative regulation of glycolytic process

negative regulation of ATP metabolic process [inference]

negative regulation of glycolytic process

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide catabolic process [inference]

regulation of glycolytic process [inference]

negative regulation of glycolytic process

negative regulation of purine nucleotide catabolic process [inference]

negative regulation of glycolytic process

negative regulation of purine nucleotide metabolic process [inference]

negative regulation of purine nucleotide catabolic process [inference]

negative regulation of glycolytic process

negative regulation of ATP metabolic process [inference]

negative regulation of glycolytic process

regulation of ATP metabolic process [inference]

regulation of glycolytic process [inference]

negative regulation of glycolytic process

negative regulation of ATP metabolic process [inference]

negative regulation of glycolytic process

positive regulation of small molecule metabolic process [inference]

positive regulation of glucose catabolic process to lactate via pyruvate

negative regulation of small molecule metabolic process [inference]

negative regulation of nucleotide metabolic process [inference]

negative regulation of nucleotide catabolic process [inference]

negative regulation of purine nucleotide catabolic process [inference]

negative regulation of glycolytic process

negative regulation of purine nucleotide metabolic process [inference]

negative regulation of purine nucleotide catabolic process [inference]

negative regulation of glycolytic process

negative regulation of ATP metabolic process [inference]

negative regulation of glycolytic process

regulation of glucose catabolic process to lactate via pyruvate [inference]

positive regulation of glucose catabolic process to lactate via pyruvate

regulation of primary metabolic process [inference]

regulation of carbohydrate metabolic process [inference]

regulation of carbohydrate catabolic process [inference]

regulation of glycolytic process [inference]

negative regulation of glycolytic process

negative regulation of carbohydrate metabolic process [inference]

negative regulation of glycolytic process

regulation of nucleobase-containing compound metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide catabolic process [inference]

negative regulation of nucleotide catabolic process [inference]

negative regulation of purine nucleotide catabolic process [inference]

negative regulation of glycolytic process

regulation of purine nucleotide catabolic process [inference]

regulation of glycolytic process [inference]

negative regulation of glycolytic process

negative regulation of purine nucleotide catabolic process [inference]

negative regulation of glycolytic process

negative regulation of nucleotide metabolic process [inference]

negative regulation of nucleotide catabolic process [inference]

negative regulation of purine nucleotide catabolic process [inference]

negative regulation of glycolytic process

negative regulation of purine nucleotide metabolic process [inference]

negative regulation of purine nucleotide catabolic process [inference]

negative regulation of glycolytic process

negative regulation of ATP metabolic process [inference]

negative regulation of glycolytic process

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide catabolic process [inference]

regulation of glycolytic process [inference]

negative regulation of glycolytic process

negative regulation of purine nucleotide catabolic process [inference]

negative regulation of glycolytic process

negative regulation of purine nucleotide metabolic process [inference]

negative regulation of purine nucleotide catabolic process [inference]

negative regulation of glycolytic process

negative regulation of ATP metabolic process [inference]

negative regulation of glycolytic process

regulation of ATP metabolic process [inference]

regulation of glycolytic process [inference]

negative regulation of glycolytic process

negative regulation of ATP metabolic process [inference]

negative regulation of glycolytic process

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleotide metabolic process [inference]

negative regulation of nucleotide catabolic process [inference]

negative regulation of purine nucleotide catabolic process [inference]

negative regulation of glycolytic process

negative regulation of purine nucleotide metabolic process [inference]

negative regulation of purine nucleotide catabolic process [inference]

negative regulation of glycolytic process

negative regulation of ATP metabolic process [inference]

negative regulation of glycolytic process

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of skeletal muscle fiber development

positive regulation of muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of skeletal muscle fiber development

regulation of muscle cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of skeletal muscle fiber development

regulation of striated muscle cell differentiation [inference]

regulation of myotube differentiation [inference]

regulation of skeletal muscle fiber development [inference]

positive regulation of skeletal muscle fiber development

positive regulation of striated muscle cell differentiation [inference]

positive regulation of skeletal muscle fiber development

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of skeletal muscle fiber development

regulation of skeletal muscle fiber development [inference]

positive regulation of skeletal muscle fiber development

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of glucose catabolic process to lactate via pyruvate

positive regulation of small molecule metabolic process [inference]

positive regulation of glucose catabolic process to lactate via pyruvate

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of skeletal muscle fiber development

positive regulation of muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of skeletal muscle fiber development

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of nucleotide catabolic process [inference]

negative regulation of purine nucleotide catabolic process [inference]

negative regulation of glycolytic process

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of nucleotide metabolic process [inference]

negative regulation of nucleotide catabolic process [inference]

negative regulation of purine nucleotide catabolic process [inference]

negative regulation of glycolytic process

negative regulation of purine nucleotide metabolic process [inference]

negative regulation of purine nucleotide catabolic process [inference]

negative regulation of glycolytic process

negative regulation of ATP metabolic process [inference]

negative regulation of glycolytic process

negative regulation of carbohydrate metabolic process [inference]

negative regulation of glycolytic process

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleotide metabolic process [inference]

negative regulation of nucleotide catabolic process [inference]

negative regulation of purine nucleotide catabolic process [inference]

negative regulation of glycolytic process

negative regulation of purine nucleotide metabolic process [inference]

negative regulation of purine nucleotide catabolic process [inference]

negative regulation of glycolytic process

negative regulation of ATP metabolic process [inference]

negative regulation of glycolytic process

negative regulation of small molecule metabolic process [inference]

negative regulation of nucleotide metabolic process [inference]

negative regulation of nucleotide catabolic process [inference]

negative regulation of purine nucleotide catabolic process [inference]

negative regulation of glycolytic process

negative regulation of purine nucleotide metabolic process [inference]

negative regulation of purine nucleotide catabolic process [inference]

negative regulation of glycolytic process

negative regulation of ATP metabolic process [inference]

negative regulation of glycolytic process

negative regulation of cellular respiration [inference]

negative regulation of oxidative phosphorylation

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling [inference]

negative regulation of calcineurin-mediated signaling [inference]

negative regulation of calcineurin-NFAT signaling cascade

regulation of multicellular organismal process [inference]

regulation of ossification [inference]

regulation of bone mineralization [inference]

positive regulation of bone mineralization [inference]

positive regulation of bone mineralization involved in bone maturation

positive regulation of ossification [inference]

positive regulation of bone mineralization [inference]

positive regulation of bone mineralization involved in bone maturation

regulation of system process [inference]

regulation of muscle system process

regulation of muscle contraction [inference]

regulation of striated muscle contraction [inference]

regulation of skeletal muscle contraction [inference]

regulation of twitch skeletal muscle contraction [inference]

regulation of fast-twitch skeletal muscle fiber contraction [inference]

positive regulation of fast-twitch skeletal muscle fiber contraction

regulation of skeletal muscle contraction by chemo-mechanical energy conversion [inference]

regulation of the force of skeletal muscle contraction

positive regulation of striated muscle contraction [inference]

positive regulation of fast-twitch skeletal muscle fiber contraction

positive regulation of muscle contraction [inference]

positive regulation of striated muscle contraction [inference]

positive regulation of fast-twitch skeletal muscle fiber contraction

regulation of muscle adaptation [inference]

regulation of skeletal muscle adaptation [inference]

transition between fast and slow fiber

regulation of relaxation of muscle [inference]

negative regulation of relaxation of muscle

positive regulation of multicellular organismal process [inference]

positive regulation of ossification [inference]

positive regulation of bone mineralization [inference]

positive regulation of bone mineralization involved in bone maturation

positive regulation of muscle contraction [inference]

positive regulation of striated muscle contraction [inference]

positive regulation of fast-twitch skeletal muscle fiber contraction

positive regulation of muscle organ development [inference]

positive regulation of striated muscle tissue development [inference]

positive regulation of skeletal muscle tissue development [inference]

negative regulation of multicellular organismal process [inference]

regulation of cold-induced thermogenesis [inference]

negative regulation of cold-induced thermogenesis

regulation of multicellular organismal development [inference]

regulation of biomineral tissue development [inference]

regulation of bone mineralization [inference]

positive regulation of bone mineralization [inference]

positive regulation of bone mineralization involved in bone maturation

positive regulation of biomineral tissue development [inference]

positive regulation of bone mineralization [inference]

positive regulation of bone mineralization involved in bone maturation

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GO Term	Evidence Code	Reference
striated muscle thin filament	TAS	PMID
plasma membrane	IBA	GO_REF
brush border	IDA	PMID
focal adhesion	ISO	GO_REF
focal adhesion	IEA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

cell junction

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

myofilament [inference]

striated muscle thin filament

cell projection

organelle [inference]

membraneless organelle [inference]

intracellular membraneless organelle [inference]

cytoskeleton [inference]

cortical cytoskeleton [inference]

cortical actin cytoskeleton

intracellular organelle [inference]

intracellular membraneless organelle [inference]

cytoskeleton [inference]

cortical cytoskeleton [inference]

cortical actin cytoskeleton

cluster of actin-based cell projections [inference]

brush border

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GO Term	Evidence Code	Reference
calcium ion binding	IEA	GO_REF
protein-macromolecule adaptor activity	TAS	PMID
identical protein binding	ISO	GO_REF
identical protein binding	IEA	GO_REF
transmembrane transporter binding	ISO	GO_REF

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

cytoskeletal protein binding [inference]

actin binding [inference]

actin filament binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

protein-containing complex binding [inference]

actin filament binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MMMVMQPEGLGAGEGPFSGGGGGEYMEQEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPRPDKGKMRFHKIANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDLIDYAKLRKDDPIGNLNTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRICKVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLHKPPRVQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQHLAEKFQQKASLHEAWTRGKEEMLNQHDYESASLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGAIEDLQDVWLVHSVEETQSLLTAHEQFKATLPEADRERGAILGIQGEIQKICQTYGLRPKSGNPYITLSSQDINNKWDTVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQGKVEEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKSNIDRLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLLTSIARTINEVENQVLTRDAKGLSQEQLNEFRASFNHFDRKRNGMMEPDDFRACLISMGYDLGEVEFARIMTMVDPNAAGVVTFQAFIDFMTRETAETDTAEQVVASFKILAGDKNYITPEELRRELPAEQAEYCIRRMAPYKGSGAPSGALDYVAFSSALYGESDL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites