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Netrin receptor UNC5C

Summary

UniProt ID: O95185
Gene Symbol: UNC5C UNC5H3
Gene ID: 8633
Organism: Homo sapiens (human)

External Links

GlyGen: O95185
PubChem: O95185
The O-GlcNAc Database: O95185
O-GlcNAcAtlas: O95185
Re-Glyco: O95185

Annotation

Keyword: Alternative splicing Alzheimer disease Amyloidosis Apoptosis Cell membrane Cell projection Developmental protein Disulfide bond Glycoprotein Immunoglobulin domain Neurodegeneration Phosphoprotein Proteomics identification Receptor Reference proteome Repeat Signal Synaptosome Transmembrane helix

Gene Ontology (GO)

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GO Term	Evidence Code	Reference
apoptotic process
axon guidance	TAS	PMID
axon guidance	IBA	GO_REF
axon guidance	IEA	GO_REF
brain development	TAS	PMID

GO Hierarchy

biological process

cellular process [inference]

cell death [inference]

programmed cell death [inference]

apoptotic process

programmed cell death involved in cell development [inference]

ectopic germ cell programmed cell death

cellular developmental process [inference]

programmed cell death involved in cell development [inference]

ectopic germ cell programmed cell death

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

anterior/posterior axon guidance

reproductive process [inference]

developmental process involved in reproduction [inference]

ectopic germ cell programmed cell death

developmental process [inference]

developmental process involved in reproduction [inference]

ectopic germ cell programmed cell death

anatomical structure development [inference]

tissue development [inference]

ganglion development [inference]

dorsal root ganglion development

animal organ development [inference]

brain development

cellular developmental process [inference]

programmed cell death involved in cell development [inference]

ectopic germ cell programmed cell death

locomotion [inference]

taxis [inference]

chemotaxis [inference]

negative chemotaxis [inference]

chemorepulsion of axon

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of neuron migration

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

regulation of developmental process [inference]

positive regulation of developmental process

regulation of cellular process [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of neuron migration

regulation of reproductive process [inference]

positive regulation of reproductive process

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GO Term	Evidence Code	Reference
plasma membrane	TAS	Reactome Reactome
plasma membrane	IDA	PMID
plasma membrane	IBA	GO_REF
plasma membrane	IEA	GO_REF GO_REF
cell surface	EXP	PMID

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cell surface

membrane [inference]

plasma membrane

cell junction [inference]

synapse

site of polarized growth [inference]

growth cone

cell projection [inference]

plasma membrane bounded cell projection [inference]

lamellipodium

neuron projection [inference]

dendrite

actin-based cell projection [inference]

filopodium

cell body [inference]

neuronal cell body

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GO Term	Evidence Code	Reference
netrin receptor activity	TAS	PMID
netrin receptor activity	IBA	GO_REF
netrin receptor activity	IEA	GO_REF GO_REF
netrin receptor activity involved in chemorepulsion	ISS	GO_REF
netrin receptor activity involved in chemorepulsion	IEA	GO_REF

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

cytoskeletal protein binding [inference]

tubulin binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

netrin receptor activity

netrin receptor activity involved in chemorepulsion

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MRKGLRATAARCGLGLGYLLQMLVLPALALLSASGTGSAAQDDDFFHELPETFPSDPPEPLPHFLIEPEEAYIVKNKPVNLYCKASPATQIYFKCNSEWVHQKDHIVDERVDETSGLIVREVSIEISRQQVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIVAKRKSTTATVIVYVNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTLCPVDGRWTPWSKWSTCGTECTHWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLCMQTAPDSDDVALYVGIVIAVIVCLAISVVVALFVYRKNHRDFESDIIDSSALNGGFQPVNIKAARQDLLAVPPDLTSAAAMYRGPVYALHDVSDKIPMTNSPILDPLPNLKIKVYNTSGAVTPQDDLSEFTSKLSPQMTQSLLENEALSLKNQSLARQTDPSCTAFGSFNSLGGHLIVPNSGVSLLIPAGAIPQGRVYEMYVTVHRKETMRPPMDDSQTLLTPVVSCGPPGALLTRPVVLTMHHCADPNTEDWKILLKNQAAQGQWEDVVVVGEENFTTPCYIQLDAEACHILTENLSTYALVGHSTTKAAAKRLKLAIFGPLCCSSLEYSIRVYCLDDTQDALKEILHLERQMGGQLLEEPKALHFKGSTHNLRLSIHDIAHSLWKSKLLAKYQEIPFYHVWSGSQRNLHCTFTLERFSLNTVELVCKLCVRQVEGEGQIFQLNCTVSEEPTGIDLPLLDPANTITTVTGPSAFSIPLPIRQKLCSSLDAPQTRGHDWRMLAHKLNLDRYLNYFATKSSPTGVILDLWEAQNFPDGNLSMLAAVLEEMGRHETVVSLAAEGQY

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites