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Cytochrome c oxidase subunit 1

Summary

UniProt ID: P00397
Gene Symbol: COI Mtco1 mt-Co1
Gene ID
Organism: Mus musculus (house mouse)

External Links

GlyGen: P00397
PubChem: P00397
RaftProt: P00397
O-GlcNAcAtlas: P00397
Re-Glyco: P00397

Annotation

Keyword: 3D-structure Calcium Copper Heme Magnesium Mitochondrion inner membrane Reference proteome Respiratory chain Sodium Translocase Transmembrane helix

Gene Ontology (GO)

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GO Term	Evidence Code	Reference
response to hypoxia	IEA	GO_REF
oxidative phosphorylation	IEA	GO_REF
response to oxidative stress	ISO	GO_REF
response to oxidative stress	IEA	GO_REF
aerobic respiration	IBA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

cellular respiration [inference]

aerobic respiration

oxidative phosphorylation

electron transport chain [inference]

respiratory electron transport chain

developmental process [inference]

anatomical structure development [inference]

cerebellum development

response to stimulus [inference]

response to stress [inference]

response to abiotic stimulus [inference]

response to electrical stimulus

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

response to chemical [inference]

response to metal ion [inference]

response to copper ion

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GO Term	Evidence Code	Reference
mitochondrion	ISO	GO_REF
mitochondrion	IDA	PMID PMID PMID PMID PMID PMID PMID
mitochondrion	IEA	GO_REF
mitochondrion	HDA	PMID
mitochondrial inner membrane	ISO	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

transmembrane transporter complex [inference]

respiratory chain complex IV

respiratory chain complex [inference]

respiratory chain complex IV

catalytic complex [inference]

cytochrome complex [inference]

respiratory chain complex IV

transporter complex [inference]

transmembrane transporter complex [inference]

respiratory chain complex IV

cellular anatomical structure [inference]

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane

mitochondrial inner membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

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GO Term	Evidence Code	Reference
cytochrome-c oxidase activity	ISS	GO_REF
cytochrome-c oxidase activity	ISO	GO_REF
cytochrome-c oxidase activity	IDA	PMID
cytochrome-c oxidase activity	IBA	GO_REF
cytochrome-c oxidase activity	IEA	GO_REF GO_REF GO_REF GO_REF

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

cytochrome-c oxidase activity

active monoatomic ion transmembrane transporter activity [inference]

cytochrome-c oxidase activity

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

oxidoreduction-driven active transmembrane transporter activity [inference]

cytochrome-c oxidase activity

active monoatomic ion transmembrane transporter activity [inference]

cytochrome-c oxidase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

tetrapyrrole binding [inference]

heme binding

electron transfer activity [inference]

cytochrome-c oxidase activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MFINRWLFSTNHKDIGTLYLLFGAWAGMVGTALSILIRAELGQPGALLGDDQIYNVIVTAHAFVMIFFMVMPMMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSMVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGIISHVVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGLDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGNIKWSPAMLWALGFIFLFTVGGLTGIVLSNSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMAGFVHWFPLFSGFTLDDTWAKAHFAIMFVGVNMTFFPQHFLGLSGMPRRYSDYPDAYTTWNTVSSMGSFISLTAVLIMIFMIWEAFASKREVMSVSYASTNLEWLHGCPPPYHTFEEPTYVKVK

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
9			G49108TO	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 6** entries
Pathway Name	Organism
Complex IV assembly	Mus musculus
Cytoprotection by HMOX1	Mus musculus
Mitochondrial protein degradation	Mus musculus
Mitochondrial translation termination	Mus musculus
Respiratory electron transport	Mus musculus
TP53 Regulates Metabolic Genes	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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External Links

Annotation

International Collaboration

Acknowledgements