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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Epidermal growth factor receptor
Summary
- UniProt ID
- P00533
- Gene Symbol
-
- EGFR
- ERBB
- ERBB1
- HER1
- Organism
- Homo sapiens (human)
External Links
- GlycoProtDB
- GPDB0011271
- GlyConnect
- GlyGen
- P00533
- PubChem
- P00533
- The Human Metabolome Database
- HMDBP01456
- The O-GlcNAc Database
- P00533
- RaftProt
- P00533
- O-GlcNAcAtlas
- P00533
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Alternative splicing
- Cell membrane
- Developmental protein
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Endoplasmic reticulum
- Endosome
- Glycoprotein
- Golgi apparatus
- Host cell receptor for virus entry
- Host-virus interaction
- Hydroxylation
- Isopeptide bond
- Methylation
- Nucleus
- Palmitate
- Phosphoprotein
- Proto-oncogene
- Reference proteome
- Repeat
- Secreted
- Signal
- Transmembrane helix
- Tyrosine-protein kinase
- Ubl conjugation
- Gene Ontology (GO)
| GO Term |
|---|
| perinuclear region of cytoplasm |
| Shc-EGFR complex |
| multivesicular body, internal vesicle lumen |
| Golgi membrane |
| extracellular space |
| nucleus |
| cytoplasm |
| plasma membrane |
| membrane |
| nuclear membrane |
Sequence
MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 56 | N-linked (GlcNAc...) (complex) asparagine; atypical; partial | |||
| 73 | N-linked (GlcNAc...) asparagine; atypical |
|
||
| 128 | N-linked (GlcNAc...) asparagine | |||
| 175 | N-linked (GlcNAc...) asparagine | |||
| 196 | N-linked (GlcNAc...) asparagine | |||
| 271 |
|
|||
| 352 | N-linked (GlcNAc...) asparagine | |||
| 361 | N-linked (GlcNAc...) asparagine | |||
| 364 |
|
|||
| 380 |
|
G48414YA
G83461WR
G84452RH
G23863VK
G78059CC
G27058EU
G10488MI
G41071NU
G06356OH
G80920RR
G90659AW
G14972EH
G87661QW
G25079LO
G42124LM
G46687AB
G49874UX
G41247ZX
G02815KT
G12793SR
G93656SY
G47518TP
G52527GH
G59536GA
G66760KM
G83460ZZ
G86182NS
G70101JE
G02886BB
G59924QI
G62765YT
G64527OM
G05724UK
G31852PQ
G39188ZX
G06110VR
G92050GC
G82830MN
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Signaling by ERBB2 | Homo sapiens |
| Signaling by ERBB2 ECD mutants | Homo sapiens |
| Signaling by ERBB2 KD Mutants | Homo sapiens |
| Signaling by ERBB2 TMD/JMD mutants | Homo sapiens |
| Signaling by ERBB4 | Homo sapiens |
| TFAP2 (AP-2) family regulates transcription of growth factors and their receptors | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
