GlyCosmos Portal

Submissions

Prothrombin

Summary

UniProt ID

P00735

Gene Symbol

F2

Gene ID

280685

Organism

Bos taurus (domestic cattle)

External Links

GlyConnect

Prothrombin

PubChem

P00735

The Human Metabolome Database

HMDBP13489

Re-Glyco

P00735

Annotation

Keyword: 3D-structure Acute phase Blood coagulation Calcium Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Gamma-carboxyglutamic acid Glycoprotein Kringle Reference proteome Repeat Secreted Serine protease Signal Zymogen

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

1

2

Next ›

Last »
GO Term	Evidence Code	Reference
proteolysis	IDA	PMID
proteolysis	IEA	GO_REF
acute-phase response
platelet activation	IBA	GO_REF
positive regulation of blood coagulation	IDA	PMID

GO Hierarchy

biological process

cellular process [inference]

cell activation [inference]

platelet activation

metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein polymerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein polymerization

multicellular organismal process [inference]

cell activation [inference]

platelet activation

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response [inference]

acute inflammatory response [inference]

acute-phase response

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of response to stimulus [inference]

positive regulation of response to wounding [inference]

positive regulation of wound healing [inference]

positive regulation of blood coagulation

positive regulation of multicellular organismal process [inference]

positive regulation of coagulation [inference]

positive regulation of blood coagulation

positive regulation of hemostasis [inference]

positive regulation of blood coagulation

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation

positive regulation of response to stimulus [inference]

positive regulation of response to wounding [inference]

positive regulation of wound healing [inference]

positive regulation of blood coagulation

regulation of response to stress [inference]

regulation of response to wounding [inference]

regulation of wound healing [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation

positive regulation of wound healing [inference]

positive regulation of blood coagulation

positive regulation of response to wounding [inference]

positive regulation of wound healing [inference]

positive regulation of blood coagulation

regulation of multicellular organismal process [inference]

regulation of coagulation [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation

positive regulation of coagulation [inference]

positive regulation of blood coagulation

positive regulation of multicellular organismal process [inference]

positive regulation of coagulation [inference]

positive regulation of blood coagulation

regulation of hemostasis [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation

positive regulation of hemostasis [inference]

positive regulation of blood coagulation

regulation of biological quality [inference]

regulation of body fluid levels [inference]

regulation of hemostasis [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation

positive regulation of hemostasis [inference]

positive regulation of blood coagulation

Displaying 1 entry
GO Term	Evidence Code	Reference
obsolete extracellular space

GO Hierarchy

cellular component

Displaying **all 5** entries
GO Term	Evidence Code	Reference
serine-type endopeptidase activity	IDA	PMID
serine-type endopeptidase activity	IBA	GO_REF
serine-type endopeptidase activity	IEA	GO_REF GO_REF
calcium ion binding	IEA	GO_REF
fibrinogen binding	IPI	PMID

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

protein-containing complex binding [inference]

fibrinogen binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MARVRGPRLPGCLALAALFSLVHSQHVFLAHQQASSLLQRARRANKGFLEEVRKGNLERECLEEPCSREEAFEALESLSATDAFWAKYTACESARNPREKLNECLEGNCAEGVGMNYRGNVSVTRSGIECQLWRSRYPHKPEINSTTHPGADLRENFCRNPDGSITGPWCYTTSPTLRREECSVPVCGQDRVTVEVIPRSGGSTTSQSPLLETCVPDRGREYRGRLAVTTSGSRCLAWSSEQAKALSKDQDFNPAVPLAENFCRNPDGDEEGAWCYVADQPGDFEYCDLNYCEEPVDGDLGDRLGEDPDPDAAIEGRTSEDHFQPFFNEKTFGAGEADCGLRPLFEKKQVQDQTEKELFESYIEGRIVEGQDAEVGLSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTVDDLLVRIGKHSRTRYERKVEKISMLDKIYIHPRYNWKENLDRDIALLKLKRPIELSDYIHPVCLPDKQTAAKLLHAGFKGRVTGWGNRRETWTTSVAEVQPSVLQVVNLPLVERPVCKASTRIRITDNMFCAGYKPGEGKRGDACEGDSGGPFVMKSPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDRLGS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
120	N-linked (GlcNAc...) asparagine	1547238		UniProt
144	N-linked (GlcNAc...) asparagine	1547238		UniProt
419	N-linked (GlcNAc...) asparagine			UniProt
unknown		447725	G57173NZ G87457SB G28916LJ G29130SY G48414YA G84467IZ	GlyConnect