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Complement C4 [Cleaved into: Complement C4 beta chain; Complement C4 alpha chain; C4a anaphylatoxin; Complement C4b; Complement C4 gamma chain]

Summary

UniProt ID

P01030

Gene Symbol

C4

Gene ID

280678

Organism

Bos taurus (domestic cattle)

External Links

Re-Glyco: P01030

Annotation

Keyword: Cleavage on pair of basic residues Complement pathway Direct protein sequencing Disulfide bond Glycoprotein Inflammatory response Phosphoprotein Reference proteome Secreted Signal Sulfation Thioester bond

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	Reference
complement activation, lectin pathway	ISS	GO_REF
inflammatory response	IEA	GO_REF
complement activation	ISS	GO_REF
complement activation	IBA	GO_REF
complement activation	IEA	GO_REF

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

complement activation

activation of immune response [inference]

complement activation

immune response [inference]

humoral immune response [inference]

complement activation

innate immune response [inference]

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

immune response [inference]

humoral immune response [inference]

complement activation

innate immune response [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

Displaying **all 4** entries
GO Term	Evidence Code	Reference
obsolete extracellular space
cell surface	ISS	GO_REF
cell surface	IEA	GO_REF
symbiont cell surface	ISS	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cell surface

other organism part [inference]

symbiont cell surface

Displaying 1 entry
GO Term	Evidence Code	Reference
antigen binding	ISS	GO_REF

GO Hierarchy

molecular function

binding [inference]

antigen binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MRLLWGLIWASCFFALSLQKPRLLLFSPSVVRIGVPLSVAVKLQDAPSGQVVRGSVFLRNPSHVNELCSPKVDFSLSSDRDFILLNVPIPQAQARICFLHLRRVPEVQLMVQSSWLRDSLSKQTDMQGVNLLFSSRRGHLFLQTDQPVYNPGQRVRYRVFALDQKMRPATDILTVTVENSQGFRVQKREVFAPFSIFQDSFLIPDISEPGTWKISARFSDSLDSNSSTQFEVKKYVLPNFEVKIIPENPYILTTPGFLSDIQVIIQARYIYGKPVQGVAYVRFGLLGEDGEKTFLRGLESQTKLVDGQCQISLQKAEFQGVLEKLNISTDDLPGLRLYVAAAVIESPGGEMEEAELTSWRFMSSPFSLDLSKTKQQLIPGVPFLLQALVRDMSGSPASSIPVKVSAKLFSGSTSKNQDFEQNTDGSGQVIVSIGVPRTISEVQLSVSAGSPYPAVGSLTVKAPLSRSSGFLSIEWQNPRPLKVGETLKLNLQAVGISGSFSYFYYMIVSRGQIVSVHREPRSHLTSISVFVDHHLVPSFHLVAFYYHGGVPVANSLRVDVQAGGCEGKLELNVDSSKAYRPGDTVKLNLKTESRALVALGAVDTALYAVGGKSHKPLDMVKVFEAMNSYDLGCGPGGGDTAPQVFKAAGLAFSDGDHRTEIRKSLSCPKESKSRKKRNVNFQKAIHEKLGQYTSPVAKRCCQDGLTRLPMARTCEQRAARVQQPACRKPFLSCCQFAESLRKKARTRGQVGLARAMELLQEEDLIEEDDIPVRSFFPENWLWKVEEVDRFSQLRLLLPDSLTTWEIHGMSLSKTTGLCVATPARLRVFREFHMHLRLPVSVRRFEQLELRPVLYNYLDSDLTVSVHVSPVEGLCLAGGGGLAQQVQVPAGSARPVGFSVVPIAAAAVSLKVVARGSFDFPVGDAISKILQVEREGALHREEMVYELNPLDPLGRTLEIPGNSDPNIIPEGDFKSFVRVTASDPLEALGSEGALSPGGLASLLRLPQGCAEQTMTLLAPTLAASRYLDKTEQWSMLPPETKDRAVDLIQKGYTRIQEFRKRDGSYGAWLHRDSSTWLTAFVLKILSLAQDQVGGSAEKLQETATWLLSQQRDDGPFHDPCPVIHREMQGGLVGSDETVALTAFVVIALHHGLAVLPDKNSEQLRRVENSISRANTFLGAKATSGLLGSHASAITAYALSLTEAPEDLRRVAHNNLMAMAKDIGDKLYWGSVTTSPSNVLSPTPAPRSPADPIPQAPAMSIETTAYGLLHLLLWEGKAELADQAASWLTRQGSFQGGFRSTQDTVVALDALSAYWIASYTAEEKGLNVTLSSLGRSGLKSHVLQLTNHQVHRLEEELQFSLGSKINVEVRGNSKGTLKVLRSYNVMDMTNTTCQDLQIEVTVMGHVEYTMEAEEDYEDYEYEDLLAGDDPEAHSRPVTPLQLFDGRRNRRRREAPKAAEERESRVQYTVCIWRTGKVGLSGMAIADITLLSGFHALRADLEKLTSLSDRYMSHFETEGPHVLLYFDSVPTSRECVGFGAVQEVPVGLVQPASAILYDYYNPEHKCSVFYGAPRKSKLLSTLCSADVCQCAEGKCPRQRRALERGQQDLEGYRMKFACYSPRVDYGFQVKVLREDSRAAFRLFETRITQVLHFTKDARATADQTRNFLVRASCRLQLEPGKEYLIMGLDGATYDLKGDPQYLLDSNSWIEEMPSERMCQSTRHRTPCAQLNSFLQEYGTQGCQV

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 6** entries
Position	Description	Source
60	N-linked (GlcNAc...) asparagine	UniProt
225	N-linked (GlcNAc...) asparagine	UniProt
326	N-linked (GlcNAc...) asparagine	UniProt
1241	O-linked (GalNAc...) threonine	UniProt
1325	N-linked (GlcNAc...) asparagine	UniProt
1388	N-linked (GlcNAc...) asparagine	UniProt