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Collagen alpha-1(IV) chain

Summary

UniProt ID: P02463
Gene Symbol: Col4a1
Gene ID: 12826
Organism: Mus musculus (house mouse)

External Links

PubChem: P02463
RaftProt: P02463
Re-Glyco: P02463

Annotation

Keyword: Angiogenesis Basement membrane Collagen Disulfide bond Glycoprotein Hydroxylation Reference proteome Repeat Signal

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	Reference
branching involved in blood vessel morphogenesis	ISO	GO_REF
branching involved in blood vessel morphogenesis	IEA	GO_REF
brain development	ISO	GO_REF
brain development	IEA	GO_REF
neuromuscular junction development	IMP	PMID

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

collagen-activated tyrosine kinase receptor signaling pathway

collagen-activated signaling pathway [inference]

collagen-activated tyrosine kinase receptor signaling pathway

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to acid chemical [inference]

cellular response to amino acid stimulus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell junction organization [inference]

synapse organization [inference]

neuromuscular junction development

extracellular structure organization [inference]

extracellular matrix organization [inference]

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

multicellular organismal process [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

branching involved in blood vessel morphogenesis

developmental process [inference]

anatomical structure morphogenesis [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

branching involved in blood vessel morphogenesis

tube morphogenesis [inference]

blood vessel morphogenesis

retinal blood vessel morphogenesis

branching morphogenesis of an epithelial tube [inference]

branching involved in blood vessel morphogenesis

epithelial tube morphogenesis [inference]

renal tubule morphogenesis

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

epithelial tube morphogenesis [inference]

renal tubule morphogenesis

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

branching involved in blood vessel morphogenesis

retina vasculature morphogenesis in camera-type eye [inference]

retinal blood vessel morphogenesis

anatomical structure development [inference]

animal organ development [inference]

brain development

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation

response to stimulus [inference]

response to chemical [inference]

response to acid chemical [inference]

response to amino acid [inference]

cellular response to amino acid stimulus

cellular response to acid chemical [inference]

cellular response to amino acid stimulus

cellular response to chemical stimulus [inference]

cellular response to acid chemical [inference]

cellular response to amino acid stimulus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to acid chemical [inference]

cellular response to amino acid stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

collagen-activated tyrosine kinase receptor signaling pathway

collagen-activated signaling pathway [inference]

collagen-activated tyrosine kinase receptor signaling pathway

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	Reference
extracellular region	TAS	Reactome Reactome Reactome Reactome
extracellular region	HDA	PMID
collagen type IV trimer	ISO	GO_REF
collagen type IV trimer	IDA	PMID
collagen type IV trimer	IBA	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

collagen trimer [inference]

network-forming collagen trimer [inference]

collagen type IV trimer

extracellular protein-containing complex [inference]

network-forming collagen trimer [inference]

collagen type IV trimer

cellular anatomical structure [inference]

extracellular region

external encapsulating structure [inference]

extracellular matrix

basement membrane

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	Reference
extracellular matrix structural constituent	ISO	GO_REF
extracellular matrix structural constituent	IEA	GO_REF GO_REF
extracellular matrix structural constituent conferring tensile strength	RCA	PMID PMID
extracellular matrix structural constituent conferring tensile strength	ISO	GO_REF
extracellular matrix structural constituent conferring tensile strength	IBA	GO_REF

GO Hierarchy

molecular function

structural molecule activity [inference]

extracellular matrix structural constituent

extracellular matrix structural constituent conferring tensile strength

binding [inference]

protein binding [inference]

growth factor binding [inference]

platelet-derived growth factor binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MGPRLSVWLLLLFAALLLHEERSRAAAKGDCGGSGCGKCDCHGVKGQKGERGLPGLQGVIGFPGMQGPEGPHGPPGQKGDAGEPGLPGTKGTRGPPGAAGYPGNPGLPGIPGQDGPPGPPGIPGCNGTKGERGPLGPPGLPGFSGNPGPPGLPGMKGDPGEILGHVPGTLLKGERGFPGIPGMPGSPGLPGLQGPVGPPGFTGPPGPPGPPGPPGEKGQMGSSFQGPKGDKGEQGVSGPPGVPGQAQVKEKGDFAPTGEKGQKGEPGFPGVPGYGEKGEPGKQGPRGKPGKDGEKGERGSPGIPGDSGYPGLPGRQGPQGEKGEAGLPGPPGTVIGTMPLGEKGDRGYPGAPGLRGEPGPKGFPGTPGQPGPPGFPTPGQAGAPGFPGERGEKGDQGFPGVSLPGPSGRDGAPGPPGPPGPPGQPGHTNGIVECQPGPPGDQGPPGTPGQPGLTGEVGQKGQKGESCLACDTEGLRGPPGPQGPPGEIGFPGQPGAKGDRGLPGRDGLEGLPGPQGSPGLIGQPGAKGEPGEIFFDMRLKGDKGDPGFPGQPGMPGRAGTPGRDGHPGLPGPKGSPGSIGLKGERGPPGGVGFPGSRGDIGPPGPPGVGPIGPVGEKGQAGFPGGPGSPGLPGPKGEAGKVVPLPGPPGAAGLPGSPGFPGPQGDRGFPGTPGRPGIPGEKGAVGQPGIGFPGLPGPKGVDGLPGEIGRPGSPGRPGFNGLPGNPGPQGQKGEPGIGLPGLKGQPGLPGIPGTPGEKGSIGGPGVPGEQGLTGPPGLQGIRGDPGPPGVQGPAGPPGVPGIGPPGAMGPPGGQGPPGSSGPPGIKGEKGFPGFPGLDMPGPKGDKGSQGLPGLTGQSGLPGLPGQQGTPGVPGFPGSKGEMGVMGTPGQPGSPGPAGTPGLPGEKGDHGLPGSSGPRGDPGFKGDKGDVGLPGMPGSMEHVDMGSMKGQKGDQGEKGQIGPTGDKGSRGDPGTPGVPGKDGQAGHPGQPGPKGDPGLSGTPGSPGLPGPKGSVGGMGLPGSPGEKGVPGIPGSQGVPGSPGEKGAKGEKGQSGLPGIGIPGRPGDKGDQGLAGFPGSPGEKGEKGSAGTPGMPGSPGPRGSPGNIGHPGSPGLPGEKGDKGLPGLDGVPGVKGEAGLPGTPGPTGPAGQKGEPGSDGIPGSAGEKGEQGVPGRGFPGFPGSKGDKGSKGEVGFPGLAGSPGIPGVKGEQGFMGPPGPQGQPGLPGTPGHPVEGPKGDRGPQGQPGLPGHPGPMGPPGFPGINGPKGDKGNQGWPGAPGVPGPKGDPGFQGMPGIGGSPGITGSKGDMGLPGVPGFQGQKGLPGLQGVKGDQGDQGVPGPKGLQGPPGPPGPYDVIKGEPGLPGPEGPPGLKGLQGPPGPKGQQGVTGSVGLPGPPGVPGFDGAPGQKGETGPFGPPGPRGFPGPPGPDGLPGSMGPPGTPSVDHGFLVTRHSQTTDDPLCPPGTKILYHGYSLLYVQGNERAHGQDLGTAGSCLRKFSTMPFLFCNINNVCNFASRNDYSYWLSTPEPMPMSMAPISGDNIRPFISRCAVCEAPAMVMAVHSQTIQIPQCPNGWSSLWIGYSFVMHTSAGAEGSGQALASPGSCLEEFRSAPFIECHGRGTCNYYANAYSFWLATIERSEMFKKPTPSTLKAGELRTHVSRCQVCMRRT

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
126	N-linked (GlcNAc...) asparagine			UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 10** entries
Pathway Name	Organism
Assembly of collagen fibrils and other multimeric structures	Mus musculus
Collagen biosynthesis and modifying enzymes	Mus musculus
Collagen degradation	Mus musculus
Crosslinking of collagen fibrils	Mus musculus
Fibronectin matrix formation	Mus musculus
Integrin cell surface interactions	Mus musculus
Laminin interactions	Mus musculus
NCAM1 interactions	Mus musculus
Non-integrin membrane-ECM interactions	Mus musculus
Signaling by PDGF	Mus musculus

Disease

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0050560	Walker-Warburg syndrome	Alliance of Genome Resources
DOID:0090125	brain small vessel disease 1	Alliance of Genome Resources
DOID:0060263	porencephaly	Alliance of Genome Resources
DOID:557	kidney disease	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements