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Apolipoprotein A-I

Summary

UniProt ID

P02647

Gene Symbol

APOA1

Gene ID

335

Organism

Homo sapiens (human)

External Links

GlyGen: P02647
PubChem: P02647
The Human Metabolome Database: HMDBP01620
RaftProt: P02647
Re-Glyco: P02647

Annotation

Keyword

3D-structure
Amyloid
Amyloidosis
Atherosclerosis
Cholesterol metabolism
Direct protein sequencing
Disease variant
Glycation
HDL
Lipid transport
Neuropathy
Oxidation
Palmitate
Phosphoprotein
Reference proteome
Repeat
Secreted
Signal

Gene Ontology (GO)

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GO Term
endocytic vesicle lumen
spherical high-density lipoprotein particle
secretory granule lumen
extracellular vesicle
extracellular region
extracellular space
plasma membrane
cytoplasmic vesicle
chylomicron
collagen-containing extracellular matrix

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

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GO Term
protein oxidation
regulation of intestinal cholesterol absorption
adrenal gland development
negative regulation of heterotypic cell-cell adhesion
acylglycerol homeostasis
negative regulation of cell adhesion molecule production
cholesterol import
cellular response to lipoprotein particle stimulus
positive regulation of cholesterol metabolic process
positive regulation of CoA-transferase activity

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GO Term
high-density lipoprotein particle binding
phosphatidylcholine-sterol O-acyltransferase activator activity
amyloid-beta binding
phospholipid binding
enzyme binding
identical protein binding
protein homodimerization activity
chemorepellent activity
high-density lipoprotein particle receptor binding
cholesterol transfer activity

Annotation information from UniProt.

Sequence

MKAAVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQGLLPVLESFKVSFLSALEEYTKKLNTQ

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
220			G57321FI	GlyGen
221			G57321FI	GlyGen
228			G57321FI	GlyGen
263	N-linked (Glc) (glycation) lysine	8261628		UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

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Pathway Name	Organism
ABC transporters in lipid homeostasis	Homo sapiens
Amyloid fiber formation	Homo sapiens
Chylomicron assembly	Homo sapiens
Chylomicron remodeling	Homo sapiens
Defective ABCA1 causes TGD	Homo sapiens
HDL assembly	Homo sapiens
HDL clearance	Homo sapiens
HDL remodeling	Homo sapiens
Heme signaling	Homo sapiens
PPARA activates gene expression	Homo sapiens

Disease

Displaying **all 8** entries
DO ID	Disease Name	Source
DOID:0080547	metabolic dysfunction-associated steatohepatitis	Alliance of Genome Resources
DOID:0080958	primary hypoalphalipoproteinemia 2	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:13810	familial hypercholesterolemia	Alliance of Genome Resources
DOID:1387	hypolipoproteinemia	Alliance of Genome Resources
DOID:1936	atherosclerosis	Alliance of Genome Resources
DOID:5844	myocardial infarction	Alliance of Genome Resources
DOID:9074	systemic lupus erythematosus	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements