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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Fibrinogen alpha chain
Summary
- UniProt ID
- P02671
- Gene Symbol
-
- FGA
- Organism
- Homo sapiens (human)
External Links
- GlycoProtDB
- GPDB0011303
- GlyConnect
- GlyGen
- P02671
- PubChem
- P02671
- The Human Metabolome Database
- HMDBP13512
- RaftProt
- P02671
Annotation
- Keyword
-
- 3D-structure
- Adaptive immunity
- Alternative splicing
- Amyloid
- Amyloidosis
- Blood coagulation
- Calcium
- Coiled coil
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Glycoprotein
- Hydroxylation
- Innate immunity
- Isopeptide bond
- Metal-binding
- Phosphoprotein
- Reference proteome
- Secreted
- Signal
- Gene Ontology (GO)
| GO Term |
|---|
| extracellular region |
| fibrinogen complex |
| extracellular space |
| plasma membrane |
| collagen-containing extracellular matrix |
| extracellular exosome |
| extracellular vesicle |
| platelet alpha granule lumen |
| platelet alpha granule |
| endoplasmic reticulum |
| GO Term |
|---|
| signaling receptor binding |
| metal ion binding |
| structural molecule activity |
| extracellular matrix structural constituent |
Sequence
MFSMRIVCLVLSVVGTAWTADSGEGDFLAEGGGVRGPRVVERHQSACKDSDWPFCSDEDWNYKCPSGCRMKGLIDEVNQDFTNRINKLKNSLFEYQKNNKDSHSLTTNIMEILRGDFSSANNRDNTYNRVSEDLRSRIEVLKRKVIEKVQHIQLLQKNVRAQLVDMKRLEVDIDIKIRSCRGSCSRALAREVDLKDYEDQQKQLEQVIAKDLLPSRDRQHLPLIKMKPVPDLVPGNFKSQLQKVPPEWKALTDMPQMRMELERPGGNEITRGGSTSYGTGSETESPRNPSSAGSWNSGSSGPGSTGNRNPGSSGTGGTATWKPGSSGPGSTGSWNSGSSGTGSTGNQNPGSPRPGSTGTWNPGSSERGSAGHWTSESSVSGSTGQWHSESGSFRPDSPGSGNARPNNPDWGTFEEVSGNVSPGTRREYHTEKLVTSKGDKELRTGKEKVTSGSTTTTRRSCSKTVTKTVIGPDGHKEVTKEVVTSEDGSDCPEAMDLGTLSGIGTLDGFRHRHPDEAAFFDTASTGKTFPGFFSPMLGEFVSETESRGSESGIFTNTKESSSHHPGIAEFPSRGKSSSYSKQFTSSTSYNRGDSTFESKSYKMADEAGSEADHEGTHSTKRGHAKSRPVRDCDDVLQTHPSGTQSGIFNIKLPGSSKIFSVYCDQETSLGGWLLIQQRMDGSLNFNRTWQDYKRGFGSLNDEGEGEFWLGNDYLHLLTQRGSVLRVELEDWAGNEAYAEYHFRVGSEAEGYALQVSSYEGTAGDALIEGSVEEGAEYTSHNNMQFSTFDRDADQWEENCAEVYGGGWWYNNCQAANLNGIYYPGGSYDPRNNSPYEIENGVVWVSFRGADYSLRAVRMKIRPLVTQ
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 320 | O-linked (GalNAc...) threonine | |||
| 338 |
|
|||
| 341 |
|
|||
| 351 | O-linked (GalNAc...) serine | |||
| 357 |
|
|||
| 359 |
|
|||
| 375 |
|
|||
| 397 |
|
|||
| 453 | N-linked (GlcNAc...) asparagine; in variant Caracas-2 |
|
||
| 499 |
|
G43417UB
G29068FM
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Amyloid fiber formation | Homo sapiens |
| Common Pathway of Fibrin Clot Formation | Homo sapiens |
| ER-Phagosome pathway | Homo sapiens |
| GRB2:SOS provides linkage to MAPK signaling for Integrins | Homo sapiens |
| IRAK4 deficiency (TLR2/4) | Homo sapiens |
| Integrin cell surface interactions | Homo sapiens |
| Integrin signaling | Homo sapiens |
| MAP2K and MAPK activation | Homo sapiens |
| MyD88 deficiency (TLR2/4) | Homo sapiens |
| MyD88:MAL(TIRAP) cascade initiated on plasma membrane | Homo sapiens |
