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Band 3 anion transport protein

Summary

UniProt ID

P02730

Gene Symbol

SLC4A1
AE1
DI
EPB3

Organism

Homo sapiens (human)

External Links

GlyConnect

1024

GlyGen

P02730

PubChem

P02730

The O-GlcNAc Database

P02730

RaftProt

P02730

O-GlcNAcAtlas

P02730

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Anion exchange
Blood group antigen
Cell membrane
Direct protein sequencing
Disease variant
Elliptocytosis
Glycoprotein
Palmitate
Phosphoprotein
Reference proteome
Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 10** of 14 in total

1

2

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GO Term
transmembrane transport
bicarbonate transport
erythrocyte development
protein localization to plasma membrane
plasma membrane phospholipid scrambling
regulation of intracellular pH
monoatomic anion transport
intracellular monoatomic ion homeostasis
blood coagulation
pH elevation

Displaying **all 9** entries
GO Term
plasma membrane
membrane
cortical cytoskeleton
cytoplasmic side of plasma membrane
extracellular exosome
ankyrin-1 complex
basolateral plasma membrane
Z disc
blood microparticle

Displaying **all 9** entries
GO Term
hemoglobin binding
ankyrin binding
protein homodimerization activity
protein-membrane adaptor activity
chloride transmembrane transporter activity
solute:inorganic anion antiporter activity
monoatomic anion transmembrane transporter activity
bicarbonate transmembrane transporter activity
chloride:bicarbonate antiporter activity

Annotation information from UniProt.

Sequence

MEELQDDYEDMMEENLEQEEYEDPDIPESQMEEPAAHDTEATATDYHTTSHPGTHKVYVELQELVMDEKNQELRWMEAARWVQLEENLGENGAWGRPHLSHLTFWSLLELRRVFTKGTVLLDLQETSLAGVANQLLDRFIFEDQIRPQDREELLRALLLKHSHAGELEALGGVKPAVLTRSGDPSQPLLPQHSSLETQLFCEQGDGGTEGHSPSGILEKIPPDSEATLVLVGRADFLEQPVLGFVRLQEAAELEAVELPVPIRFLFVLLGPEAPHIDYTQLGRAAATLMSERVFRIDAYMAQSRGELLHSLEGFLDCSLVLPPTDAPSEQALLSLVPVQRELLRRRYQSSPAKPDSSFYKGLDLNGGPDDPLQQTGQLFGGLVRDIRRRYPYYLSDITDAFSPQVLAAVIFIYFAALSPAITFGGLLGEKTRNQMGVSELLISTAVQGILFALLGAQPLLVVGFSGPLLVFEEAFFSFCETNGLEYIVGRVWIGFWLILLVVLVVAFEGSFLVRFISRYTQEIFSFLISLIFIYETFSKLIKIFQDHPLQKTYNYNVLMVPKPQGPLPNTALLSLVLMAGTFFFAMMLRKFKNSSYFPGKLRRVIGDFGVPISILIMVLVDFFIQDTYTQKLSVPDGFKVSNSSARGWVIHPLGLRSEFPIWMMFASALPALLVFILIFLESQITTLIVSKPERKMVKGSGFHLDLLLVVGMGGVAALFGMPWLSATTVRSVTHANALTVMGKASTPGAAAQIQEVKEQRISGLLVAVLVGLSILMEPILSRIPLAVLFGIFLYMGVTSLSGIQLFDRILLLFKPPKYHPDVPYVKRVKTWRMHLFTGIQIICLAVLWVVKSTPASLALPFVLILTVPLRRVLLPLIFRNVELQCLDADDAKATFDEEEGRDEYDEVAMPV

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 5** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
162			G49108TO	GlyGen The O-GlcNAc Database
224			G49108TO	GlyGen The O-GlcNAc Database
642	N-linked (GlcNAc...) (complex) asparagine	10861210 24121512 35835865	G03644CB G75568BH G16125XL G44753VC G27947YN G28622IK G90382BL G30970QQ G80479JV G85282JO G79666IR G92135MA G98611JV G43734MM G43669FQ G45395BF G07246CJ G85554PZ G40926MX G43223CG G40574BA G08918WF G00912UN G49906RN G27915IV G87661QW G83646BJ G27058EU G43769HG G60033FS G41071NU G59626AS G01650EU G65184UU G42124LM G90659AW G37399XV G47644PP G72790NZ G10486CT G05049YU G28541PG G18647XP G72787SB G23719VF G11314AS G35029YA G57776ZU G06110VR	UniProt GlyGen GlyConnect
745			G49108TO	GlyGen The O-GlcNAc Database
			G49108TO	GlyConnect

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
Bicarbonate transporters	Homo sapiens
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)	Homo sapiens
Erythrocytes take up carbon dioxide and release oxygen	Homo sapiens
Erythrocytes take up oxygen and release carbon dioxide	Homo sapiens

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

International Collaboration

Acknowledgements