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Transthyretin

Summary

UniProt ID

P02766

Gene Symbol

PALB
TTR

Gene ID

[7276]

Organism

Homo sapiens (human)

External Links

GlyGen: P02766
PubChem: P02766
The Human Metabolome Database: HMDBP01831
RaftProt: P02766
Re-Glyco: P02766

Annotation

Keyword: 3D-structure Amyloid Amyloidosis Cytoplasm Direct protein sequencing Disease variant Gamma-carboxyglutamic acid Glycoprotein Neuropathy Phosphoprotein Proteomics identification Reference proteome Secreted Signal Sulfation Thyroid hormone Transport

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	Reference
retinoid metabolic process	TAS	Reactome
retinoid metabolic process	IEA	GO_REF
negative regulation of glomerular filtration
purine nucleobase metabolic process	IBA	GO_REF
phototransduction, visible light

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

phototransduction [inference]

phototransduction, visible light

metabolic process [inference]

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

purine nucleobase metabolic process

lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

purine nucleobase metabolic process

purine-containing compound metabolic process [inference]

purine nucleobase metabolic process

response to stimulus [inference]

response to external stimulus [inference]

detection of external stimulus [inference]

detection of light stimulus [inference]

phototransduction [inference]

phototransduction, visible light

detection of visible light [inference]

phototransduction, visible light

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

detection of light stimulus [inference]

phototransduction [inference]

phototransduction, visible light

detection of visible light [inference]

phototransduction, visible light

detection of abiotic stimulus [inference]

detection of light stimulus [inference]

phototransduction [inference]

phototransduction, visible light

detection of visible light [inference]

phototransduction, visible light

detection of stimulus [inference]

detection of external stimulus [inference]

detection of light stimulus [inference]

phototransduction [inference]

phototransduction, visible light

detection of visible light [inference]

phototransduction, visible light

detection of abiotic stimulus [inference]

detection of light stimulus [inference]

phototransduction [inference]

phototransduction, visible light

detection of visible light [inference]

phototransduction, visible light

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of glomerular filtration

regulation of cellular process [inference]

signal transduction [inference]

phototransduction [inference]

phototransduction, visible light

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of renal system process [inference]

regulation of glomerular filtration [inference]

negative regulation of glomerular filtration

negative regulation of multicellular organismal process [inference]

negative regulation of glomerular filtration

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	Reference
extracellular region	NAS	PMID
extracellular region	TAS	Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome
extracellular region	IEA	GO_REF GO_REF
extracellular region	HDA	PMID
obsolete extracellular space

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical structure [inference]

extracellular region

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

azurophil granule lumen

intracellular organelle lumen [inference]

vacuolar lumen [inference]

azurophil granule lumen

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

azurophil granule lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	Reference
hormone activity
hormone binding	IEA	GO_REF
identical protein binding	IPI	PMID PMID PMID PMID PMID PMID PMID
protein-containing complex binding	IEA	GO_REF
molecular sequestering activity	TAS	Reactome

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

identical protein binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

hormone activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

hormone activity

molecular sequestering activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
23				GlyGen
118	N-linked (GlcNAc...) asparagine	16335952 19167329		UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 6** entries
Pathway Name	Organism
Amyloid fiber formation	Homo sapiens
Defective visual phototransduction due to STRA6 loss of function	Homo sapiens
Neutrophil degranulation	Homo sapiens
Non-integrin membrane-ECM interactions	Homo sapiens
Retinoid metabolism and transport	Homo sapiens
The canonical retinoid cycle in rods (twilight vision)	Homo sapiens

Disease

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0050638	hereditary systemic amyloidosis 1	Alliance of Genome Resources
DOID:0070466	carpal tunnel syndrome 1	Alliance of Genome Resources
DOID:0080219	dystransthyretinemic hyperthyroxinemia	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:9120	amyloidosis	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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External Links

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International Collaboration

Acknowledgements