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Structural polyprotein

Summary

UniProt ID

P03316

Gene Symbol

Organism

Sindbis virus

External Links

Re-Glyco: P03316

Annotation

Keyword: 3D-structure Clathrin-mediated endocytosis of virus by host Cleavage on pair of basic residues Coiled coil Direct protein sequencing Disulfide bond Fusion of virus membrane with host endosomal membrane Glycoprotein Host Golgi apparatus Host cell membrane Host cytoplasm Host endoplasmic reticulum Host nucleus Palmitate RNA-binding Reference proteome Ribosomal frameshifting Serine protease T=4 icosahedral capsid protein Transmembrane helix Viral attachment to host entry receptor Viral envelope protein Viral ion channel

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	Reference
proteolysis	IEA	GO_REF GO_REF
virion attachment to host cell	IMP	PMID
virion attachment to host cell	IEA	GO_REF
monoatomic ion transmembrane transport	IEA	GO_REF
ion transmembrane transport	IEA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor-mediated endocytosis of virus by host cell [inference]

clathrin-dependent endocytosis of virus by host cell

clathrin-dependent endocytosis [inference]

clathrin-dependent endocytosis of virus by host cell

transmembrane transport [inference]

monoatomic ion transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

membrane organization [inference]

membrane fusion

viral process [inference]

membrane fusion involved in viral entry into host cell [inference]

fusion of virus membrane with host endosome membrane

viral translational frameshifting

biological process involved in interspecies interaction between organisms [inference]

modulation of process of another organism [inference]

symbiont-mediated perturbation of host process [inference]

symbiont-mediated perturbation of host cellular process [inference]

symbiont-mediated perturbation of host signal transduction pathway [inference]

symbiont-mediated suppression of host signal transduction pathway [inference]

symbiont-mediated suppression of host toll-like receptor signaling pathway

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

symbiont-mediated perturbation of host process [inference]

symbiont-mediated perturbation of host cellular process [inference]

symbiont-mediated perturbation of host signal transduction pathway [inference]

symbiont-mediated suppression of host signal transduction pathway [inference]

symbiont-mediated suppression of host toll-like receptor signaling pathway

adhesion of symbiont to host [inference]

adhesion of symbiont to host cell [inference]

virion attachment to host cell

receptor-mediated virion attachment to host cell [inference]

entry receptor-mediated virion attachment to host cell

symbiont entry into host [inference]

symbiont entry into host cell [inference]

endocytosis involved in viral entry into host cell [inference]

receptor-mediated endocytosis of virus by host cell [inference]

clathrin-dependent endocytosis of virus by host cell

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic ion transmembrane transport

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor-mediated endocytosis of virus by host cell [inference]

clathrin-dependent endocytosis of virus by host cell

clathrin-dependent endocytosis [inference]

clathrin-dependent endocytosis of virus by host cell

transmembrane transport [inference]

monoatomic ion transmembrane transport

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor-mediated endocytosis of virus by host cell [inference]

clathrin-dependent endocytosis of virus by host cell

clathrin-dependent endocytosis [inference]

clathrin-dependent endocytosis of virus by host cell

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	Reference
viral envelope	IEA	GO_REF
host cell plasma membrane	EXP	PMID PMID PMID PMID
host cell plasma membrane	IDA	PMID
host cell plasma membrane	IEA	GO_REF
T=4 icosahedral viral capsid	IDA	PMID

GO Hierarchy

cellular component

virion component [inference]

viral capsid [inference]

icosahedral viral capsid [inference]

T=4 icosahedral viral capsid

viral membrane [inference]

viral envelope

cellular anatomical structure [inference]

other organism part [inference]

host cellular component [inference]

host cell part [inference]

host cell membrane [inference]

host cell plasma membrane

host intracellular part [inference]

host intracellular organelle [inference]

host intracellular membrane-bounded organelle [inference]

host cell cytoplasm part [inference]

Displaying **all 5** entries
GO Term	Evidence Code	Reference
RNA binding	IEA	GO_REF
serine-type endopeptidase activity	IEA	GO_REF
structural molecule activity	IEA	GO_REF
channel activity	IEA	GO_REF
ubiquitin-like protein ligase binding	IPI	PMID

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

structural molecule activity

transporter activity [inference]

transmembrane transporter activity [inference]

passive transmembrane transporter activity [inference]

channel activity

binding [inference]

nucleic acid binding [inference]

RNA binding

protein binding [inference]

enzyme binding [inference]

ubiquitin-like protein ligase binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MNRGFFNMLGRRPFPAPTAMWRPRRRRQAAPMPARNGLASQIQQLTTAVSALVIGQATRPQPPRPRPPPRQKKQAPKQPPKPKKPKTQEKKKKQPAKPKPGKRQRMALKLEADRLFDVKNEDGDVIGHALAMEGKVMKPLHVKGTIDHPVLSKLKFTKSSAYDMEFAQLPVNMRSEAFTYTSEHPEGFYNWHHGAVQYSGGRFTIPRGVGGRGDSGRPIMDNSGRVVAIVLGGADEGTRTALSVVTWNSKGKTIKTTPEGTEEWSAAPLVTAMCLLGNVSFPCDRPPTCYTREPSRALDILEENVNHEAYDTLLNAILRCGSSGRSKRSVIDDFTLTSPYLGTCSYCHHTVPCFSPVKIEQVWDEADDNTIRIQTSAQFGYDQSGAASANKYRYMSLKQDHTVKEGTMDDIKISTSGPCRRLSYKGYFLLAKCPPGDSVTVSIVSSNSATSCTLARKIKPKFVGREKYDLPPVHGKKIPCTVYDRLKETTAGYITMHRPRPHAYTSYLEESSGKVYAKPPSGKNITYECKCGDYKTGTVSTRTEITGCTAIKQCVAYKSDQTKWVFNSPDLIRHDDHTAQGKLHLPFKLIPSTCMVPVAHAPNVIHGFKHISLQLDTDHLTLLTTRRLGANPEPTTEWIVGKTVRNFTVDRDGLEYIWGNHEPVRVYAQESAPGDPHGWPHEIVQHYYHRHPVYTILAVASATVAMMIGVTVAVLCACKARRECLTPYALAPNAVIPTSLALLCCVRSANAETFTETMSYLWSNSQPFFWVQLCIPLAAFIVLMRCCSCCLPFLSGCRRLPGEGRRLRTCDHCSKCATDTV

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 5** entries
Position	Description	PubMed ID	Source
278	N-linked (GlcNAc...) asparagine; by host		UniProt
524	N-linked (GlcNAc...) asparagine; by host	12388725	UniProt
646	N-linked (GlcNAc...) asparagine; by host	12388725	UniProt
945	N-linked (GlcNAc...) asparagine; by host	12388725	UniProt
1051	N-linked (GlcNAc...) asparagine; by host	12388725	UniProt