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Coagulation factor XI

Summary

UniProt ID: P03951
Gene Symbol: F11
Gene ID: 2160
Organism: Homo sapiens (human)

External Links

GlycoProtDB

GPDB0011341

GlyConnect

Coagulation factor XI

GlyGen

P03951

PubChem

P03951

Re-Glyco

P03951

Annotation

Keyword: 3D-structure Alternative splicing Blood coagulation Direct protein sequencing Disease variant Disulfide bond Glycoprotein Heparin-binding Proteomics identification Reference proteome Repeat Secreted Serine protease Signal Zymogen

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	Reference
blood coagulation	NAS	PMID
blood coagulation	TAS	PMID
blood coagulation	IDA	PMID
plasminogen activation	IDA	PMID
plasminogen activation	IBA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

zymogen activation [inference]

plasminogen activation

protein maturation [inference]

protein processing [inference]

zymogen activation [inference]

plasminogen activation

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

zymogen activation [inference]

plasminogen activation

protein maturation [inference]

protein processing [inference]

zymogen activation [inference]

plasminogen activation

multicellular organismal process [inference]

coagulation [inference]

blood coagulation

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of fibrinolysis

negative regulation of biological process [inference]

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

positive regulation of fibrinolysis

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

positive regulation of fibrinolysis

negative regulation of multicellular organismal process [inference]

negative regulation of coagulation [inference]

negative regulation of blood coagulation [inference]

positive regulation of fibrinolysis

negative regulation of hemostasis [inference]

negative regulation of blood coagulation [inference]

positive regulation of fibrinolysis

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation [inference]

positive regulation of fibrinolysis

regulation of fibrinolysis [inference]

positive regulation of fibrinolysis

negative regulation of response to external stimulus [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

positive regulation of fibrinolysis

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

positive regulation of fibrinolysis

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

positive regulation of fibrinolysis

regulation of response to stress [inference]

regulation of response to wounding [inference]

regulation of wound healing [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation [inference]

positive regulation of fibrinolysis

regulation of fibrinolysis [inference]

positive regulation of fibrinolysis

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

positive regulation of fibrinolysis

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

positive regulation of fibrinolysis

regulation of multicellular organismal process [inference]

regulation of coagulation [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation [inference]

positive regulation of fibrinolysis

regulation of fibrinolysis [inference]

positive regulation of fibrinolysis

negative regulation of coagulation [inference]

negative regulation of blood coagulation [inference]

positive regulation of fibrinolysis

negative regulation of multicellular organismal process [inference]

negative regulation of coagulation [inference]

negative regulation of blood coagulation [inference]

positive regulation of fibrinolysis

regulation of hemostasis [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation [inference]

positive regulation of fibrinolysis

regulation of fibrinolysis [inference]

positive regulation of fibrinolysis

negative regulation of hemostasis [inference]

negative regulation of blood coagulation [inference]

positive regulation of fibrinolysis

regulation of biological quality [inference]

regulation of body fluid levels [inference]

hemostasis [inference]

blood coagulation

regulation of hemostasis [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation [inference]

positive regulation of fibrinolysis

regulation of fibrinolysis [inference]

positive regulation of fibrinolysis

negative regulation of hemostasis [inference]

negative regulation of blood coagulation [inference]

positive regulation of fibrinolysis

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GO Term	Evidence Code	Reference
extracellular region	NAS	PMID
extracellular region	TAS	Reactome Reactome Reactome
extracellular region	IDA	PMID
extracellular region	IEA	GO_REF GO_REF GO_REF
obsolete extracellular space

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

membrane

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	Reference
serine-type endopeptidase activity	NAS	PMID
serine-type endopeptidase activity	TAS	PMID
serine-type endopeptidase activity	IEA	GO_REF GO_REF
heparin binding
serine-type peptidase activity	IBA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity

serine-type endopeptidase activity

serine-type exopeptidase activity [inference]

serine-type aminopeptidase activity

exopeptidase activity [inference]

aminopeptidase activity [inference]

serine-type aminopeptidase activity

serine-type exopeptidase activity [inference]

serine-type aminopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity

serine-type endopeptidase activity

serine-type exopeptidase activity [inference]

serine-type aminopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity

serine-type endopeptidase activity

serine-type exopeptidase activity [inference]

serine-type aminopeptidase activity

exopeptidase activity [inference]

aminopeptidase activity [inference]

serine-type aminopeptidase activity

serine-type exopeptidase activity [inference]

serine-type aminopeptidase activity

binding [inference]

protein binding [inference]

identical protein binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MIFLYQVVHFILFTSVSGECVTQLLKDTCFEGGDITTVFTPSAKYCQVVCTYHPRCLLFTFTAESPSEDPTRWFTCVLKDSVTETLPRVNRTAAISGYSFKQCSHQISACNKDIYVDLDMKGINYNSSVAKSAQECQERCTDDVHCHFFTYATRQFPSLEHRNICLLKHTQTGTPTRITKLDKVVSGFSLKSCALSNLACIRDIFPNTVFADSNIDSVMAPDAFVCGRICTHHPGCLFFTFFSQEWPKESQRNLCLLKTSESGLPSTRIKKSKALSGFSLQSCRHSIPVFCHSSFYHDTDFLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQASCNEGKGKCYLKLSSNGSPTKILHGRGGISGYTLRLCKMDNECTTKIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLVTNEECQKRYRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTNVVEYVDWILEKTQAV

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 5** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
90	N-linked (GlcNAc...) (complex) asparagine	25092234	G08527WT G15169WU G47518TP G93860XO G11629QQ G58232MG G13661YX G52527GH G08146BT G22310AV G42358LZ G48414YA G06356OH G37868ZX	UniProt GlyGen GlyConnect
126	N-linked (GlcNAc...) (complex) asparagine	16335952 23090970 25092234 29391424 29741879 37074911	G47518TP G93860XO G13661YX G52527GH G56784JY G08146BT G22310AV G40574BA G08918WF G75983OB G00912UN G42358LZ G48414YA G83460ZZ G06356OH G37868ZX G59626AS G80920RR G62765YT G10486CT G31852PQ G41247ZX	GlycoProtDB UniProt GlyGen GlyConnect
163	N-linked (GlcNAc...) (complex) asparagine; atypical	25092234 29391424	G57888GL G42358LZ G48414YA G06356OH G37868ZX	UniProt GlyGen GlyConnect
450	N-linked (GlcNAc...) (complex) asparagine	16335952 19159218 23090970 24190977 25092234 29391424 29741879 37074911	G37881RL G11629QQ G13661YX G52527GH G08146BT G22310AV G45395BF G10846ZT G40574BA G08918WF G00912UN G42358LZ G48414YA G70619PT G06356OH G37868ZX G59626AS G80920RR G62765YT G10486CT G31852PQ	GlycoProtDB UniProt GlyGen GlyConnect
491	N-linked (GlcNAc...) (complex) asparagine	16335952 19159218 1998667 23090970 25092234 29391424 29671580 29741879 37074911	G08527WT G15169WU G06247RL G47518TP G93860XO G11629QQ G58232MG G13661YX G27947YN G52527GH G90382BL G08146BT G22310AV G45395BF G10846ZT G40574BA G08918WF G47737VJ G00912UN G42358LZ G48414YA G83646BJ G45495MK G84452RH G41071NU G70619PT G06356OH G37868ZX G59626AS G80920RR G23863VK G57818FI G62765YT G10486CT G22140GZ G50045TK G31852PQ	UniProt GlyGen GlyConnect

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
Amplification and propagation of coagulation cascade	Homo sapiens
Defective F9 activation	Homo sapiens
FXIIa, PKa activate coagulation factors	Homo sapiens
Regulation of clotting cascade	Homo sapiens

Disease

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:2229	factor XI deficiency	Alliance of Genome Resources
DOID:0060903	thrombosis	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements