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Lysosomal acid glucosylceramidase

Summary

UniProt ID: P04062
Gene Symbol: GBA1 GBA GC GLUC
Gene ID: 2629
Organism: Homo sapiens (human)

External Links

GlycoProtDB

GPDB0011346

GlyConnect

Glucosylceramidase

GlyGen

P04062

PubChem

P04062

SwissLipids

SLP:000001387

The Human Metabolome Database

HMDBP01795

The O-GlcNAc Database

P04062

RaftProt

P04062

O-GlcNAcAtlas

P04062

Re-Glyco

P04062

Annotation

Keyword: 3D-structure Alternative initiation Alternative splicing Cholesterol metabolism Direct protein sequencing Disease variant Disulfide bond Gaucher disease Glycoprotein Glycosidase Glycosyltransferase Ichthyosis Lysosome Membrane Neurodegeneration Parkinson disease Parkinsonism Pharmaceutical Proteomics identification Reference proteome Signal Sphingolipid metabolism

Gene Ontology (GO)

Displaying entries **1 - 5** of 61 in total

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GO Term	Evidence Code	Reference
mitophagy
glucosylceramide catabolic process	IDA	PMID PMID PMID
glucosylceramide catabolic process	IMP	PMID PMID PMID PMID
glucosylceramide catabolic process	IBA	GO_REF
glucosylceramide catabolic process	IEA	GO_REF GO_REF

GO Hierarchy

biological process

immune system process [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

T cell differentiation in thymus

T cell activation [inference]

T cell differentiation [inference]

T cell differentiation in thymus

leukocyte migration [inference]

mononuclear cell migration [inference]

lymphocyte migration

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

T cell differentiation in thymus

T cell activation [inference]

T cell differentiation [inference]

T cell differentiation in thymus

metabolic process [inference]

generation of precursor metabolites and energy [inference]

electron transport chain [inference]

respiratory electron transport chain

catabolic process [inference]

autophagy

autophagy of mitochondrion [inference]

mitophagy

macroautophagy [inference]

mitophagy

macromolecule catabolic process [inference]

protein catabolic process [inference]

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process [inference]

glycosylceramide catabolic process [inference]

glucosylceramide catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process [inference]

glycosylceramide catabolic process [inference]

glucosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process [inference]

glucosylceramide catabolic process

carbohydrate derivative catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process [inference]

glycosylceramide catabolic process [inference]

glucosylceramide catabolic process

glycosyl compound catabolic process [inference]

glycoside catabolic process [inference]

beta-glucoside catabolic process

biosynthetic process [inference]

lipid biosynthetic process [inference]

glycolipid biosynthetic process

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycolipid biosynthetic process

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein metabolic process [inference]

protein catabolic process [inference]

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

glycosylceramide metabolic process [inference]

glucosylceramide metabolic process [inference]

glucosylceramide catabolic process

glycosylceramide catabolic process [inference]

glucosylceramide catabolic process

ceramide biosynthetic process

ceramide catabolic process [inference]

glycosylceramide catabolic process [inference]

glucosylceramide catabolic process

glycosphingolipid metabolic process [inference]

glycosylceramide metabolic process [inference]

glucosylceramide metabolic process [inference]

glucosylceramide catabolic process

glycosylceramide catabolic process [inference]

glucosylceramide catabolic process

glycosphingolipid catabolic process [inference]

glycosylceramide catabolic process [inference]

glucosylceramide catabolic process

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process [inference]

glycosylceramide catabolic process [inference]

glucosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process [inference]

glucosylceramide catabolic process

sphingoid metabolic process [inference]

sphingosine metabolic process [inference]

sphingosine biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

lipid biosynthetic process [inference]

glycolipid biosynthetic process

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process [inference]

glycosylceramide catabolic process [inference]

glucosylceramide catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process [inference]

glycosylceramide catabolic process [inference]

glucosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process [inference]

glucosylceramide catabolic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosylceramide metabolic process [inference]

glucosylceramide metabolic process [inference]

glucosylceramide catabolic process

glycosylceramide catabolic process [inference]

glucosylceramide catabolic process

glycosphingolipid catabolic process [inference]

glycosylceramide catabolic process [inference]

glucosylceramide catabolic process

glycolipid biosynthetic process

glycolipid catabolic process [inference]

glycosphingolipid catabolic process [inference]

glycosylceramide catabolic process [inference]

glucosylceramide catabolic process

protein metabolic process [inference]

protein catabolic process [inference]

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

diol metabolic process [inference]

sphingosine metabolic process [inference]

sphingosine biosynthetic process

diol biosynthetic process [inference]

sphingosine biosynthetic process

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

secondary alcohol metabolic process [inference]

cholesterol metabolic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

carbohydrate derivative metabolic process [inference]

glycoside metabolic process [inference]

glycoside catabolic process [inference]

beta-glucoside catabolic process

carbohydrate derivative catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process [inference]

glycosylceramide catabolic process [inference]

glucosylceramide catabolic process

glycosyl compound catabolic process [inference]

glycoside catabolic process [inference]

beta-glucoside catabolic process

carbohydrate derivative biosynthetic process [inference]

glycolipid biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosylceramide metabolic process [inference]

glucosylceramide metabolic process [inference]

glucosylceramide catabolic process

glycosylceramide catabolic process [inference]

glucosylceramide catabolic process

glycosphingolipid catabolic process [inference]

glycosylceramide catabolic process [inference]

glucosylceramide catabolic process

glycolipid biosynthetic process

glycolipid catabolic process [inference]

glycosphingolipid catabolic process [inference]

glycosylceramide catabolic process [inference]

glucosylceramide catabolic process

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

neuron apoptotic process

cell population proliferation [inference]

glial cell proliferation [inference]

microglial cell proliferation

leukocyte proliferation [inference]

macrophage proliferation [inference]

microglial cell proliferation

stem cell proliferation [inference]

hematopoietic stem cell proliferation

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

myeloid leukocyte differentiation [inference]

macrophage differentiation [inference]

microglia differentiation

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

T cell differentiation in thymus

macrophage differentiation [inference]

microglia differentiation

glial cell differentiation [inference]

microglia differentiation

myeloid cell differentiation [inference]

myeloid leukocyte differentiation [inference]

macrophage differentiation [inference]

microglia differentiation

neuron differentiation [inference]

central nervous system neuron differentiation [inference]

pyramidal neuron differentiation

cell maturation

cell motility [inference]

cell migration [inference]

leukocyte migration [inference]

mononuclear cell migration [inference]

lymphocyte migration

cellular response to stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to stress [inference]

cellular response to starvation

process utilizing autophagic mechanism [inference]

autophagy

autophagy of mitochondrion [inference]

mitophagy

macroautophagy [inference]

mitophagy

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vacuole organization [inference]

lytic vacuole organization [inference]

lysosome organization

autophagosome organization

nutrient storage [inference]

lipid storage

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

T cell differentiation in thymus

T cell activation [inference]

T cell differentiation [inference]

T cell differentiation in thymus

system process [inference]

nervous system process [inference]

neuromuscular process

behavior [inference]

motor behavior

determination of adult lifespan

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

brain morphogenesis

developmental maturation [inference]

anatomical structure maturation [inference]

cell maturation

anatomical structure formation involved in morphogenesis [inference]

cerebellar Purkinje cell layer formation

anatomical structure development [inference]

tissue development [inference]

epidermis development [inference]

skin epidermis development [inference]

establishment of skin barrier

epithelium development [inference]

skin epidermis development [inference]

establishment of skin barrier

animal organ development [inference]

hematopoietic or lymphoid organ development [inference]

thymus development

gland development [inference]

thymus development

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

myeloid leukocyte differentiation [inference]

macrophage differentiation [inference]

microglia differentiation

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

T cell differentiation in thymus

macrophage differentiation [inference]

microglia differentiation

glial cell differentiation [inference]

microglia differentiation

myeloid cell differentiation [inference]

myeloid leukocyte differentiation [inference]

macrophage differentiation [inference]

microglia differentiation

neuron differentiation [inference]

central nervous system neuron differentiation [inference]

pyramidal neuron differentiation

cell maturation

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to starvation

response to starvation [inference]

cellular response to starvation

immune response

response to abiotic stimulus [inference]

response to pH

response to endogenous stimulus [inference]

response to hormone [inference]

response to estrogen

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

response to dexamethasone

response to thyroid hormone

response to nutrient levels [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

response to starvation [inference]

cellular response to starvation

response to chemical [inference]

response to hormone [inference]

response to estrogen

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

response to dexamethasone

response to thyroid hormone

response to lipid [inference]

response to testosterone

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

response to dexamethasone

response to peptide [inference]

response to cytokine [inference]

response to tumor necrosis factor [inference]

cellular response to tumor necrosis factor

cellular response to cytokine stimulus [inference]

cellular response to tumor necrosis factor

response to oxygen-containing compound [inference]

response to ketone [inference]

cellular response to stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to stress [inference]

cellular response to starvation

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

termination of signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of TOR signaling

regulation of MAPK cascade [inference]

negative regulation of MAPK cascade

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

termination of signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

positive regulation of biological process [inference]

positive regulation of action potential [inference]

positive regulation of neuronal action potential

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of mitophagy [inference]

positive regulation of type 2 mitophagy

positive regulation of autophagy of mitochondrion [inference]

positive regulation of mitophagy [inference]

positive regulation of type 2 mitophagy

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of cell communication [inference]

positive regulation of transmission of nerve impulse [inference]

positive regulation of neuronal action potential

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system process [inference]

positive regulation of transmission of nerve impulse [inference]

positive regulation of neuronal action potential

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

termination of signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-6 production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-6 production

negative regulation of protein metabolic process

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

termination of signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of cellular component organization [inference]

negative regulation of protein-containing complex assembly

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

termination of signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

negative regulation of defense response [inference]

negative regulation of inflammatory response

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-6 production

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

termination of signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of TOR signaling

regulation of MAPK cascade [inference]

negative regulation of MAPK cascade

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

regulation of inflammatory response [inference]

negative regulation of inflammatory response

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

termination of signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

negative regulation of defense response [inference]

negative regulation of inflammatory response

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

regulation of response to stress [inference]

regulation of defense response [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response

regulation of inflammatory response [inference]

negative regulation of inflammatory response

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

termination of signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of TOR signaling

regulation of MAPK cascade [inference]

negative regulation of MAPK cascade

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

positive regulation of cell communication [inference]

positive regulation of transmission of nerve impulse [inference]

positive regulation of neuronal action potential

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

termination of signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

regulation of transmission of nerve impulse [inference]

positive regulation of transmission of nerve impulse [inference]

positive regulation of neuronal action potential

regulation of neuronal action potential [inference]

positive regulation of neuronal action potential

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-6 production

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-6 production

regulation of interleukin-6 production [inference]

negative regulation of interleukin-6 production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-6 production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-6 production

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-6 production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-6 production

negative regulation of protein metabolic process

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of mitophagy [inference]

positive regulation of type 2 mitophagy

positive regulation of autophagy of mitochondrion [inference]

positive regulation of mitophagy [inference]

positive regulation of type 2 mitophagy

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of mitophagy [inference]

positive regulation of type 2 mitophagy

positive regulation of autophagy of mitochondrion [inference]

positive regulation of mitophagy [inference]

positive regulation of type 2 mitophagy

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of autophagy [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of mitophagy [inference]

positive regulation of type 2 mitophagy

positive regulation of autophagy of mitochondrion [inference]

positive regulation of mitophagy [inference]

positive regulation of type 2 mitophagy

regulation of macroautophagy

positive regulation of macroautophagy [inference]

positive regulation of mitophagy [inference]

positive regulation of type 2 mitophagy

regulation of mitophagy [inference]

positive regulation of mitophagy [inference]

positive regulation of type 2 mitophagy

regulation of type 2 mitophagy [inference]

positive regulation of type 2 mitophagy

regulation of autophagy of mitochondrion [inference]

regulation of mitophagy [inference]

positive regulation of mitophagy [inference]

positive regulation of type 2 mitophagy

regulation of type 2 mitophagy [inference]

positive regulation of type 2 mitophagy

positive regulation of autophagy of mitochondrion [inference]

positive regulation of mitophagy [inference]

positive regulation of type 2 mitophagy

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of proteasomal protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of protein catabolic process in the vacuole [inference]

regulation of lysosomal protein catabolic process

regulation of ubiquitin-dependent protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-6 production

regulation of interleukin-6 production [inference]

negative regulation of interleukin-6 production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-6 production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-6 production

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-6 production

negative regulation of protein metabolic process

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of proteasomal protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of protein catabolic process in the vacuole [inference]

regulation of lysosomal protein catabolic process

regulation of ubiquitin-dependent protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of protein metabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of proteasomal protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of protein catabolic process in the vacuole [inference]

regulation of lysosomal protein catabolic process

regulation of ubiquitin-dependent protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of protein metabolic process

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

regulation of neuron apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of mitophagy [inference]

positive regulation of type 2 mitophagy

positive regulation of autophagy of mitochondrion [inference]

positive regulation of mitophagy [inference]

positive regulation of type 2 mitophagy

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of cell communication [inference]

positive regulation of transmission of nerve impulse [inference]

positive regulation of neuronal action potential

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-6 production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-6 production

negative regulation of protein metabolic process

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

termination of signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of cellular component organization [inference]

negative regulation of protein-containing complex assembly

regulation of cellular component organization [inference]

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly

negative regulation of cellular component organization [inference]

negative regulation of protein-containing complex assembly

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-6 production

regulation of interleukin-6 production [inference]

negative regulation of interleukin-6 production

regulation of system process [inference]

regulation of nervous system process [inference]

positive regulation of nervous system process [inference]

positive regulation of transmission of nerve impulse [inference]

positive regulation of neuronal action potential

regulation of transmission of nerve impulse [inference]

positive regulation of transmission of nerve impulse [inference]

positive regulation of neuronal action potential

regulation of neuronal action potential [inference]

positive regulation of neuronal action potential

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system process [inference]

positive regulation of transmission of nerve impulse [inference]

positive regulation of neuronal action potential

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-6 production

regulation of action potential [inference]

positive regulation of action potential [inference]

positive regulation of neuronal action potential

regulation of neuronal action potential [inference]

positive regulation of neuronal action potential

regulation of biological quality [inference]

regulation of membrane potential [inference]

regulation of action potential [inference]

positive regulation of action potential [inference]

positive regulation of neuronal action potential

regulation of neuronal action potential [inference]

positive regulation of neuronal action potential

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	Reference
lysosome	IMP	PMID
lysosome	IEA	GO_REF
lysosomal membrane	ISS	PMID
lysosomal membrane	TAS	Reactome
lysosomal membrane	IDA	PMID

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

vacuolar lumen [inference]

lysosomal lumen

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	Reference
galactosylceramidase activity	IEA	GO_REF GO_REF
glucosylceramidase activity	IDA	PMID PMID PMID PMID PMID
glucosylceramidase activity	IMP	PMID PMID PMID PMID PMID
glucosylceramidase activity	IBA	GO_REF
glucosylceramidase activity	IEA	GO_REF GO_REF GO_REF GO_REF GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

hexosyltransferase activity [inference]

glucosyltransferase activity

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds [inference]

glucosidase activity [inference]

beta-glucosidase activity

steryl-beta-glucosidase activity

glycosylceramidase activity [inference]

binding [inference]

protein binding [inference]

signaling receptor binding

scavenger receptor binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 8** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
58	N-linked (GlcNAc...) asparagine	12792654 17139081 29741879	G48584BU G70101JE G65092SV G14260UH G64527OM G05724UK G39188ZX G55037KS	UniProt GlyGen GlyConnect
60				GlyGen
98	N-linked (GlcNAc...) asparagine	12754519 17139081 19159218 24190977 29741879	G62894KT G11314AS	UniProt GlyGen GlyConnect
185	N-linked (GlcNAc...) asparagine	12754519 17139081 24190977 29741879 32125861	G34617SM G25059MC G30769VJ G90093AU G08110WX G25451PN G45495MK G84452RH G46524LG G47448YK G12313PD G62894KT G11870QZ G55383ZG G72291OX G74724QE	GlycoProtDB UniProt GlyGen GlyConnect
187		30059200 34019948 34725712 35254053 38665916 40596516	G49108TO	GlyGen The O-GlcNAc Database
309	N-linked (GlcNAc...) asparagine	12754519 19159218 24190977 29741879 32125861	G86795LJ G81198YO G08146BT G22310AV G71146HJ G75983OB G45495MK G84452RH G80920RR G64527OM G11870QZ G39188ZX G74724QE	GlycoProtDB UniProt GlyGen GlyConnect
310		30059200 34019948 34725712 35254053 38665916 40596516	G49108TO	GlyGen The O-GlcNAc Database
501	N-linked (GlcNAc...) asparagine			UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 2** entries
Pathway Name	Organism
Association of TriC/CCT with target proteins during biosynthesis	Homo sapiens
Glycosphingolipid catabolism	Homo sapiens

Human Protein Atlas

ENSG00000177628

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Disease

Displaying **all 10** entries
DO ID	Disease Name	Source
DOID:12217	Lewy body dementia	Alliance of Genome Resources
DOID:0112250	Gaucher's disease type IIIC	Glyco-Disease Genes Database Alliance of Genome Resources
DOID:0080855	Parkinsonism	Alliance of Genome Resources
DOID:1926	Gaucher's disease	Glyco-Disease Genes Database Glyco-Disease Genes Database Glyco-Disease Genes Database Glyco-Disease Genes Database Alliance of Genome Resources
DOID:14330	Parkinson's disease	Alliance of Genome Resources
DOID:0110960	Gaucher's disease perinatal lethal	Glyco-Disease Genes Database Alliance of Genome Resources
DOID:0110957	Gaucher's disease type I	Glyco-Disease Genes Database Alliance of Genome Resources
DOID:0110958	Gaucher's disease type II	Glyco-Disease Genes Database Alliance of Genome Resources
DOID:0060892	late onset Parkinson's disease	Alliance of Genome Resources
DOID:0110959	Gaucher's disease type III	Glyco-Disease Genes Database Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements