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Envelope glycoprotein gp160

Summary

UniProt ID

P04578

Gene Symbol

Gene ID

155971

Organism

HIV-1 M:B_HXB2R

External Links

PubChem: P04578
Re-Glyco: P04578

Annotation

Keyword: 3D-structure AIDS Apoptosis Clathrin-mediated endocytosis of virus by host Cleavage on pair of basic residues Coiled coil Disulfide bond Fusion of virus membrane with host endosomal membrane Glycoprotein Host cell membrane Host endosome Palmitate Reference proteome Signal Transmembrane helix Viral attachment to host cell Viral envelope protein Viral immunoevasion

Gene Ontology (GO)

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	Reference
actin filament organization	IDA	PMID
virion attachment to host cell	IDA	PMID
virion attachment to host cell	IEA	GO_REF GO_REF
fusion of virus membrane with host plasma membrane	IDA	PMID
fusion of virus membrane with host plasma membrane	IEA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor-mediated endocytosis of virus by host cell [inference]

clathrin-dependent endocytosis of virus by host cell

clathrin-dependent endocytosis [inference]

clathrin-dependent endocytosis of virus by host cell

cellular component organization or biogenesis [inference]

cellular component organization [inference]

membrane organization [inference]

membrane fusion [inference]

fusion of virus membrane with host plasma membrane

supramolecular fiber organization [inference]

actin filament organization

viral process [inference]

viral protein processing

membrane fusion involved in viral entry into host cell [inference]

biological process involved in interspecies interaction between organisms [inference]

modulation of process of another organism [inference]

symbiont-mediated perturbation of host process [inference]

symbiont-mediated perturbation of host defense response [inference]

symbiont-mediated perturbation of host immune response [inference]

symbiont-mediated evasion of host immune response

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

symbiont-mediated perturbation of host process [inference]

symbiont-mediated perturbation of host defense response [inference]

symbiont-mediated perturbation of host immune response [inference]

symbiont-mediated evasion of host immune response

adhesion of symbiont to host [inference]

adhesion of symbiont to host cell [inference]

virion attachment to host cell

symbiont entry into host [inference]

symbiont entry into host cell

endocytosis involved in viral entry into host cell [inference]

receptor-mediated endocytosis of virus by host cell [inference]

clathrin-dependent endocytosis of virus by host cell

response to host [inference]

symbiont-mediated response to host defenses [inference]

response to host immune response [inference]

symbiont-mediated evasion of host immune response

response to other organism [inference]

response to host [inference]

symbiont-mediated response to host defenses [inference]

response to host immune response [inference]

symbiont-mediated evasion of host immune response

response to stimulus [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to host [inference]

symbiont-mediated response to host defenses [inference]

response to host immune response [inference]

symbiont-mediated evasion of host immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to host [inference]

symbiont-mediated response to host defenses [inference]

response to host immune response [inference]

symbiont-mediated evasion of host immune response

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor-mediated endocytosis of virus by host cell [inference]

clathrin-dependent endocytosis of virus by host cell

clathrin-dependent endocytosis [inference]

clathrin-dependent endocytosis of virus by host cell

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor-mediated endocytosis of virus by host cell [inference]

clathrin-dependent endocytosis of virus by host cell

clathrin-dependent endocytosis [inference]

clathrin-dependent endocytosis of virus by host cell

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation [inference]

positive regulation of establishment of T cell polarity

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation [inference]

positive regulation of establishment of T cell polarity

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

positive regulation of T cell activation [inference]

positive regulation of establishment of T cell polarity

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation [inference]

positive regulation of establishment of T cell polarity

regulation of localization [inference]

regulation of protein localization [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to membrane [inference]

positive regulation of receptor clustering

regulation of protein localization to membrane [inference]

regulation of receptor clustering [inference]

positive regulation of receptor clustering

positive regulation of protein localization to membrane [inference]

positive regulation of receptor clustering

regulation of cellular localization [inference]

regulation of plasma membrane raft polarization [inference]

positive regulation of plasma membrane raft polarization

regulation of protein localization to membrane [inference]

regulation of receptor clustering [inference]

positive regulation of receptor clustering

positive regulation of protein localization to membrane [inference]

positive regulation of receptor clustering

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation [inference]

positive regulation of establishment of T cell polarity

positive regulation of cellular process [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

positive regulation of establishment of T cell polarity

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation [inference]

positive regulation of establishment of T cell polarity

positive regulation of cellular component organization [inference]

positive regulation of plasma membrane raft polarization

positive regulation of protein localization to membrane [inference]

positive regulation of receptor clustering

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation [inference]

positive regulation of establishment of T cell polarity

positive regulation of protein localization [inference]

positive regulation of protein localization to membrane [inference]

positive regulation of receptor clustering

regulation of cellular process [inference]

regulation of cell adhesion [inference]

regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

positive regulation of establishment of T cell polarity

regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

positive regulation of establishment of T cell polarity

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

positive regulation of establishment of T cell polarity

regulation of establishment or maintenance of cell polarity [inference]

regulation of establishment of cell polarity [inference]

regulation of establishment of T cell polarity [inference]

positive regulation of establishment of T cell polarity

positive regulation of cellular process [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

positive regulation of establishment of T cell polarity

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation [inference]

positive regulation of establishment of T cell polarity

positive regulation of cellular component organization [inference]

positive regulation of plasma membrane raft polarization

positive regulation of protein localization to membrane [inference]

positive regulation of receptor clustering

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation [inference]

positive regulation of establishment of T cell polarity

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

positive regulation of T cell activation [inference]

positive regulation of establishment of T cell polarity

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation [inference]

positive regulation of establishment of T cell polarity

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation [inference]

positive regulation of establishment of T cell polarity

regulation of cellular component organization [inference]

positive regulation of cellular component organization [inference]

positive regulation of plasma membrane raft polarization

regulation of plasma membrane organization [inference]

regulation of plasma membrane raft polarization [inference]

positive regulation of plasma membrane raft polarization

regulation of cellular localization [inference]

regulation of plasma membrane raft polarization [inference]

positive regulation of plasma membrane raft polarization

regulation of protein localization to membrane [inference]

regulation of receptor clustering [inference]

positive regulation of receptor clustering

positive regulation of protein localization to membrane [inference]

positive regulation of receptor clustering

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation [inference]

positive regulation of establishment of T cell polarity

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

positive regulation of T cell activation [inference]

positive regulation of establishment of T cell polarity

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation [inference]

positive regulation of establishment of T cell polarity

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation [inference]

positive regulation of establishment of T cell polarity

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation [inference]

positive regulation of establishment of T cell polarity

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	Reference
membrane	IEA	GO_REF
viral envelope	IEA	GO_REF GO_REF
host cell plasma membrane	IDA	PMID
host cell plasma membrane	IEA	GO_REF GO_REF
host cell endosome membrane	IEA	GO_REF GO_REF

GO Hierarchy

cellular component

virion component [inference]

viral membrane [inference]

viral envelope

virion membrane

cellular anatomical structure [inference]

membrane

other organism part [inference]

host cellular component [inference]

host cell part [inference]

host cell membrane [inference]

Displaying **all 2** entries
GO Term	Evidence Code	Reference
structural molecule activity	IEA	GO_REF GO_REF
receptor ligand activity	IDA	PMID

GO Hierarchy

molecular function

structural molecule activity

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MRVKEKYQHLWRWGWRWGTMLLGMLMICSATEKLWVTVYYGVPVWKEATTTLFCASDAKAYDTEVHNVWATHACVPTDPNPQEVVLVNVTENFNMWKNDMVEQMHEDIISLWDQSLKPCVKLTPLCVSLKCTDLKNDTNTNSSSGRMIMEKGEIKNCSFNISTSIRGKVQKEYAFFYKLDIIPIDNDTTSYKLTSCNTSVITQACPKVSFEPIPIHYCAPAGFAILKCNNKTFNGTGPCTNVSTVQCTHGIRPVVSTQLLLNGSLAEEEVVIRSVNFTDNAKTIIVQLNTSVEINCTRPNNNTRKRIRIQRGPGRAFVTIGKIGNMRQAHCNISRAKWNNTLKQIASKLREQFGNNKTIIFKQSSGGDPEIVTHSFNCGGEFFYCNSTQLFNSTWFNSTWSTEGSNNTEGSDTITLPCRIKQIINMWQKVGKAMYAPPISGQIRCSSNITGLLLTRDGGNSNNESEIFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTKAKRRVVQREKRAVGIGALFLGFLGAAGSTMGAASMTLTVQARQLLSGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARILAVERYLKDQQLLGIWGCSGKLICTTAVPWNASWSNKSLEQIWNHTTWMEWDREINNYTSLIHSLIEESQNQQEKNEQELLELDKWASLWNWFNITNWLWYIKLFIMIVGGLVGLRIVFAVLSIVNRVRQGYSPLSFQTHLPTPRGPDRPEGIEEEGGERDRDRSIRLVNGSLALIWDDLRSLCLFSYHRLRDLLLIVTRIVELLGRRGWEALKYWWNLLQYWSQELKNSAVSLLNATAIAVAEGTDRVIEVVQGACRAIRHIPRRIRQGLERILL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **1 - 10** of 29 in total

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Position	Description	PubMed ID	Source
88	N-linked (GlcNAc...) asparagine; by host	19965434 26972002	UniProt
136	N-linked (GlcNAc...) asparagine; by host		UniProt
141	N-linked (GlcNAc...) asparagine; by host		UniProt
156	N-linked (GlcNAc...) asparagine; by host	26972002	UniProt
160	N-linked (GlcNAc...) asparagine; by host	26972002	UniProt
186	N-linked (GlcNAc...) asparagine; by host		UniProt
197	N-linked (GlcNAc...) asparagine; by host	11188697 14981267 26972002 9641677	UniProt
230	N-linked (GlcNAc...) asparagine; by host		UniProt
234	N-linked (GlcNAc...) asparagine; by host	11188697 14981267 26972002	UniProt
241	N-linked (GlcNAc...) asparagine; by host		UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 6** entries
Pathway Name	Organism
Alpha-defensins	Homo sapiens
Assembly Of The HIV Virion	Homo sapiens
Binding and entry of HIV virion	Homo sapiens
Budding and maturation of HIV virion	Homo sapiens
Dectin-2 family	Homo sapiens
Synthesis and processing of ENV and VPU	Homo sapiens

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

International Collaboration

Acknowledgements