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MIRAGE
Interleukin-4
Summary
- UniProt ID
- P05112
- Gene Symbol
- IL4
- Gene ID
- 3565
- Organism
- Homo sapiens (human)
Annotation
- Keyword
- 3D-structure Alternative splicing B-cell activation Cytokine Direct protein sequencing Disulfide bond Glycoprotein Growth factor Proteomics identification Reference proteome Secreted Signal
Gene Ontology (GO)
| GO Term | Evidence Code | Reference |
|---|---|---|
| negative regulation of transcription by RNA polymerase II | ||
| immune response | ||
| immune response | ||
| cell surface receptor signaling pathway via JAK-STAT | ||
| cell surface receptor signaling pathway via JAK-STAT |
GO Hierarchy
- positive regulation of cellular respiration
- positive regulation of cellular respiration
- positive regulation of cellular respiration
biological process
cellular process [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
positive regulation of immune system process [inference]
regulation of leukocyte activation [inference]
regulation of immune effector process [inference]
regulation of immune response
regulation of locomotion [inference]
positive regulation of biological process [inference]
positive regulation of immune system process [inference]
positive regulation of cellular process [inference]
positive regulation of metabolic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of cell activation [inference]
positive regulation of response to stimulus [inference]
positive regulation of multicellular organismal process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
positive regulation of response to stimulus [inference]
regulation of immune response
regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
positive regulation of biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
positive regulation of macromolecule biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of macromolecule metabolic process [inference]
regulation of phosphorus metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of macromolecule metabolic process [inference]
regulation of DNA metabolic process [inference]
regulation of RNA metabolic process [inference]
regulation of small molecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
positive regulation of metabolic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of cell activation [inference]
negative regulation of cellular process [inference]
regulation of cell activation [inference]
regulation of multicellular organismal process [inference]
regulation of cytokine production [inference]
regulation of cell activation [inference]
positive regulation of multicellular organismal process [inference]
| GO Term | Evidence Code | Reference |
|---|---|---|
| cytokine activity | ||
| interleukin-4 receptor binding | ||
| interleukin-4 receptor binding | ||
| growth factor activity | ||
| growth factor activity |
GO Hierarchy
Sequence
MGLTSQLLPPLFFLLACAGNFVHGHKCDITLQEIIKTLNSLTEQKTLCTELTVTDIFAASKNTTEKETFCRAATVLRQFYSHHEKDTRCLGATAQQFHRHKQLIRFLKRLDRNLWGLAGLNSCPVKEANQSTLENFLERLKTIMREKYSKCSS
Glycosylation Sites
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Differentiation of naive CD4+ T cells to T helper 2 cells (Th2 cells) | Homo sapiens |
| Interleukin-18 signaling | Homo sapiens |
| Interleukin-4 and Interleukin-13 signaling | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:2048 | autoimmune hepatitis | |
| DOID:3310 | atopic dermatitis | |
| DOID:10652 | Alzheimer's disease | |
| DOID:0050625 | biliary tract benign neoplasm | |
| DOID:8924 | autoimmune thrombocytopenic purpura | |
| DOID:2377 | multiple sclerosis | |
| DOID:2043 | hepatitis B | |
| DOID:2841 | asthma | |
| DOID:1883 | hepatitis C | |
| DOID:13375 | temporal arteritis |
