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Myeloperoxidase

Summary

UniProt ID: P05164
Gene Symbol: MPO
Gene ID: 4353
Organism: Homo sapiens (human)

External Links

GlyConnect

Myeloperoxidase

GlyGen

P05164

PubChem

P05164

The Human Metabolome Database

HMDBP00282

The O-GlcNAc Database

P05164

RaftProt

P05164

O-GlcNAcAtlas

P05164

Re-Glyco

P05164

Annotation

Keyword: 3D-structure Alternative splicing Calcium Direct protein sequencing Disease variant Disulfide bond Glycoprotein Heme Hydrogen peroxide Lysosome Oxidation Proteomics identification Reference proteome Signal

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	Reference
response to yeast
obsolete hypochlorous acid biosynthetic process
respiratory burst involved in defense response
defense response	TAS	PMID
response to oxidative stress	TAS	PMID PMID

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

respiratory burst involved in defense response

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

hydrogen peroxide catabolic process

respiratory burst [inference]

respiratory burst involved in defense response

reactive oxygen species metabolic process [inference]

superoxide metabolic process [inference]

removal of superoxide radicals

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-containing complex remodeling [inference]

protein-lipid complex remodeling [inference]

plasma lipoprotein particle remodeling [inference]

low-density lipoprotein particle remodeling

protein-lipid complex organization [inference]

protein-lipid complex remodeling [inference]

plasma lipoprotein particle remodeling [inference]

low-density lipoprotein particle remodeling

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle remodeling [inference]

low-density lipoprotein particle remodeling

cellular detoxification [inference]

cellular oxidant detoxification [inference]

removal of superoxide radicals

multicellular organismal process [inference]

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle remodeling [inference]

low-density lipoprotein particle remodeling

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

response to fungus [inference]

response to stimulus [inference]

response to stress [inference]

defense response

response to oxidative stress

response to external stimulus [inference]

response to mechanical stimulus

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

response to fungus [inference]

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

response to fungus [inference]

response to abiotic stimulus [inference]

response to mechanical stimulus

response to nutrient levels [inference]

response to food

response to chemical [inference]

response to food

response to lipid [inference]

response to lipopolysaccharide

response to oxygen-containing compound [inference]

response to lipopolysaccharide

response to transition metal nanoparticle [inference]

response to gold nanoparticle

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cellular process [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

detoxification [inference]

cellular detoxification [inference]

cellular oxidant detoxification [inference]

removal of superoxide radicals

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	Reference
extracellular region	TAS	Reactome
extracellular region	IDA	PMID PMID PMID
extracellular region	IEA	GO_REF GO_REF
extracellular region	HDA	PMID
obsolete extracellular space

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

azurophil granule lumen

intracellular organelle lumen [inference]

vacuolar lumen [inference]

azurophil granule lumen

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

azurophil granule lumen

endocytic vesicle lumen [inference]

phagocytic vesicle lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

azurophil granule

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

vacuole [inference]

lytic vacuole [inference]

lysosome

primary lysosome [inference]

azurophil granule

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

azurophil granule

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

vacuole [inference]

lytic vacuole [inference]

lysosome

primary lysosome [inference]

azurophil granule

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

azurophil granule

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

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GO Term	Evidence Code	Reference
chromatin binding	TAS	PMID
peroxidase activity	TAS	PMID
peroxidase activity	IDA	PMID PMID PMID PMID PMID PMID PMID PMID PMID PMID PMID PMID PMID PMID
peroxidase activity	IBA	GO_REF
peroxidase activity	IEA	GO_REF GO_REF GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on peroxide as acceptor [inference]

peroxidase activity

binding [inference]

chromatin binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

tetrapyrrole binding [inference]

heme binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

antioxidant activity [inference]

peroxidase activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MGVPFFSSLRCMVDLGPCWAGGLTAEMKLLLALAGLLAILATPQPSEGAAPAVLGEVDTSLVLSSMEEAKQLVDKAYKERRESIKQRLRSGSASPMELLSYFKQPVAATRTAVRAADYLHVALDLLERKLRSLWRRPFNVTDVLTPAQLNVLSKSSGCAYQDVGVTCPEQDKYRTITGMCNNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPGVKRNGFPVALARAVSNEIVRFPTDQLTPDQERSLMFMQWGQLLDHDLDFTPEPAARASFVTGVNCETSCVQQPPCFPLKIPPNDPRIKNQADCIPFFRSCPACPGSNITIRNQINALTSFVDASMVYGSEEPLARNLRNMSNQLGLLAVNQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSSEMPELTSMHTLLLREHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGPTAMRKYLPTYRSYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNRYQPMEPNPRVPLSRVFFASWRVVLEGGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYNAWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPLLACIIGTQFRKLRDGDRFWWENEGVFSMQQRQALAQISLPRIICDNTGITTVSKNNIFMSNSYPRDFVNCSTLPALNLASWREAS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 10** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
139	N-linked (GlcNAc...) asparagine	16335952 37074911	G83460ZZ	UniProt GlyGen
214				GlyGen
322		28657654 30237853 40596516	G49108TO	GlyGen The O-GlcNAc Database GlyConnect
323	N-linked (GlcNAc...) asparagine	16740002 20332087 29391424 29671580 29741879 30237853 37074911	G15169WU G94917XT G06247RL G47518TP G11629QQ G90093AU G34989PA G00912UN G48414YA G80920RR G29299MO G62765YT G11870QZ G47644PP G05724UK G31852PQ G90575OW G33609NS G39188ZX G41247ZX G02815KT G06110VR G92050GC G92275SC	UniProt GlyGen GlyConnect
355	N-linked (GlcNAc...) asparagine	19159218 20332087 23843990 29391424 29741879 32125861 37074911	G25541YH G37881RL G11629QQ G27947YN G52527GH G56784JY G59536GA G40574BA G75983OB G62765YT G05724UK G31852PQ G82020ZR G39188ZX G41247ZX G80966KZ G02815KT G06110VR G55220VL G92050GC G28681TP	UniProt GlyGen GlyConnect
391	N-linked (GlcNAc...) asparagine	19159218 20332087 23843990 29741879 30237853 37074911	G35697OJ G01650EU G80920RR G37399XV G39188ZX G41247ZX G25637MV G02815KT G06110VR G92050GC G14669DU G28681TP	UniProt GlyGen GlyConnect
481		30237853	G74724QE	GlyGen GlyConnect
483	N-linked (GlcNAc...) asparagine	10766826 16335952 16740002 20332087 23843990 29391424 29671580 29741879 30237853 37074911	G22310AV G88374WZ G40926MX G59536GA G00912UN G48414YA G08293MJ G27058EU G84452RH G96091TT G06356OH G59626AS G08290VR G63041LO G77547TA G29299MO G11870QZ G47644PP G05049YU G18647XP G85269DF G95865ZB G31852PQ G23719VF G49874UX G11314AS G29880MM G41247ZX G25637MV G50282JC G36379GD G94854LT G84349RE G74724QE G82348BZ G92275SC	UniProt GlyGen GlyConnect
553				GlyGen
729	N-linked (GlcNAc...) asparagine	20332087 29391424 37074911	G37881RL G52527GH G22310AV G47644PP	UniProt GlyGen GlyConnect

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 2** entries
Pathway Name	Organism
Events associated with phagocytolytic activity of PMN cells	Homo sapiens
Neutrophil degranulation	Homo sapiens

Human Protein Atlas

ENSG00000005381

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Disease

Displaying entries **1 - 10** of 14 in total

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DO ID	Disease Name	Source
DOID:161	keratosis	Alliance of Genome Resources
DOID:1485	cystic fibrosis	Alliance of Genome Resources
DOID:850	lung disease	Alliance of Genome Resources
DOID:2841	asthma	Alliance of Genome Resources
DOID:783	end stage renal disease	Alliance of Genome Resources
DOID:5082	liver cirrhosis	Alliance of Genome Resources
DOID:1287	cardiovascular system disease	Alliance of Genome Resources
DOID:1324	lung cancer	Alliance of Genome Resources
DOID:0080162	lupus nephritis	Alliance of Genome Resources
DOID:1793	pancreatic cancer	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements