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Interleukin-6

Summary

UniProt ID

P05231

Gene Symbol

IFNB2
IL6

Gene ID

3569

Organism

Homo sapiens (human)

External Links

GlyGen: P05231
PubChem: P05231
The Human Metabolome Database: HMDBP02087
Re-Glyco: P05231

Annotation

Keyword

3D-structure
Acute phase
Cytokine
Direct protein sequencing
Disulfide bond
Glycoprotein
Growth factor
Phosphoprotein
Reference proteome
Secreted
Signal

Gene Ontology (GO)

Displaying **all 4** entries
GO Term
interleukin-6 receptor complex
extracellular region
extracellular space
endoplasmic reticulum lumen

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **31 - 40** of 90 in total

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GO Term
positive regulation of tumor necrosis factor production
positive regulation of peptidyl-serine phosphorylation
positive regulation of MAPK cascade
negative regulation of fat cell differentiation
response to glucocorticoid
cellular response to hydrogen peroxide
cellular response to lipopolysaccharide
hepatocyte proliferation
cellular response to virus
positive regulation of miRNA transcription

Displaying **all 4** entries
GO Term
cytokine activity
growth factor activity
identical protein binding
interleukin-6 receptor binding

Annotation information from UniProt.

Sequence

MNSFSTSAFGPVAFSLGLLLVLPAAFPAPVPPGEDSKDVAAPHRQPLTSSERIDKQIRYILDGISALRKETCNKSNMCESSKEALAENNLNLPKMAEKDGCFQSGFNEETCLVKIITGLLEFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKNLDAITTPDPTTNASLLTKLQAQNQWLQDMTTHLILRSFKEFLQSSLRALRQM

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
73	N-linked (GlcNAc...) asparagine	1883960		UniProt GlyGen
89				GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying entries **1 - 10** of 11 in total

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Pathway Name	Organism
ADORA2B mediated anti-inflammatory cytokines production	Homo sapiens
CD163 mediating an anti-inflammatory response	Homo sapiens
Interleukin-10 signaling	Homo sapiens
Interleukin-4 and Interleukin-13 signaling	Homo sapiens
Interleukin-6 signaling	Homo sapiens
MAPK1 (ERK2) activation	Homo sapiens
MAPK3 (ERK1) activation	Homo sapiens
Post-translational protein phosphorylation	Homo sapiens
Regulation of IGF Activity by IGFBP	Homo sapiens
Senescence-Associated Secretory Phenotype (SASP)	Homo sapiens

Disease

Displaying entries **41 - 44** of 44 in total

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DO ID	Disease Name	Source
DOID:9351	diabetes mellitus	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources
DOID:9744	type 1 diabetes mellitus	Alliance of Genome Resources
DOID:9970	obesity	Alliance of Genome Resources