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Complement C2

Summary

UniProt ID: P06681
Gene Symbol: C2 hCG_43694
Gene ID: 717
Organism: Homo sapiens (human)

External Links

GlycoProtDB

GPDB0011405

GlyConnect

Complement C2

GlyGen

P06681

PubChem

P06681

Re-Glyco

P06681

Annotation

Keyword: 3D-structure Age-related macular degeneration Alternative splicing Complement pathway Direct protein sequencing Disease variant Disulfide bond Glycoprotein Metal-binding Proteomics identification Reference proteome Repeat Secreted Serine protease Signal Sushi

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	Reference
proteolysis	IEA	GO_REF
complement activation	IDA	PMID PMID PMID
complement activation	IMP	PMID
complement activation	IBA	GO_REF
complement activation	IEA	GO_REF GO_REF

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

complement activation

activation of immune response [inference]

complement activation

immune response [inference]

humoral immune response [inference]

complement activation

innate immune response [inference]

complement activation, GZMK pathway

cellular process [inference]

metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

complement activation, GZMK pathway

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

complement activation, GZMK pathway

immune response [inference]

humoral immune response [inference]

complement activation

innate immune response [inference]

complement activation, GZMK pathway

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to other organism [inference]

response to bacterium

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

complement activation, GZMK pathway

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to other organism [inference]

response to bacterium

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

complement activation, GZMK pathway

response to endogenous stimulus [inference]

response to hormone [inference]

response to thyroid hormone

response to nutrient levels [inference]

response to nutrient

response to chemical [inference]

response to nutrient

response to hormone [inference]

response to thyroid hormone

response to lipid [inference]

response to lipopolysaccharide

response to oxygen-containing compound [inference]

response to lipopolysaccharide

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

regulation of localization [inference]

regulation of transport [inference]

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of apoptotic cell clearance

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of apoptotic cell clearance

regulation of phagocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of apoptotic cell clearance

regulation of apoptotic cell clearance [inference]

positive regulation of apoptotic cell clearance

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of apoptotic cell clearance

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of apoptotic cell clearance

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of apoptotic cell clearance

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of apoptotic cell clearance

regulation of phagocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of apoptotic cell clearance

regulation of apoptotic cell clearance [inference]

positive regulation of apoptotic cell clearance

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of apoptotic cell clearance

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of apoptotic cell clearance

regulation of phagocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of apoptotic cell clearance

regulation of apoptotic cell clearance [inference]

positive regulation of apoptotic cell clearance

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	Reference
extracellular region	TAS	PMID Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome
extracellular region	IEA	GO_REF GO_REF
obsolete extracellular space
cell surface	EXP	PMID
cell surface	IEA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

other organism part [inference]

symbiont cell surface

Displaying **all 4** entries
GO Term	Evidence Code	Reference
serine-type endopeptidase activity	EXP	PMID PMID PMID PMID PMID
serine-type endopeptidase activity	IDA	PMID PMID PMID PMID PMID PMID
serine-type endopeptidase activity	IEA	GO_REF GO_REF
metal ion binding

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MGPLMVLFCLLFLYPGLADSAPSCPQNVNISGGTFTLSHGWAPGSLLTYSCPQGLYPSPASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQPYSYDFPEDVAPALGTSFSHMLGATNPTQKTKESLGRKIQIQRSGHLNLYLLLDCSQSVSENDFLIFKESASLMVDRIFSFEINVSVAIITFASEPKVLMSVLNDNSRDMTEVISSLENANYKDHENGTGTNTYAALNSVYLMMNNQMRLLGMETMAWQEIRHAIILLTDGKSNMGGSPKTAVDHIREILNINQKRNDYLDIYAIGVGKLDVDWRELNELGSKKDGERHAFILQDTKALHQVFEHMLDVSKLTDTICGVGNMSANASDQERTPWHVTIKPKSQETCRGALISDQWVLTAAHCFRDGNDHSLWRVNVGDPKSQWGKEFLIEKAVISPGFDVFAKKNQGILEFYGDDIALLKLAQKVKMSTHARPICLPCTMEANLALRRPQGSTCRDHENELLNKQSVPAHFVALNGSKLNINLKMGVEWTSCAEVVSQEKTMFPNLTDVREVVTDQFLCSGTQEDESPCKGESGGAVFLERRFRFFQVGLVSWGLYNPCLGSADKNSRKRAPRSKVPPPRDFHINLFRMQPWLRQHLGDVLNFLPL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 9** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
29	N-linked (GlcNAc...) asparagine		G94917XT	UniProt GlyGen
112	N-linked (GlcNAc...) asparagine	16335952 19159218 23090970 29391424 29741879 37074911	G12341GU G70232NH G06247RL G27947YN G45395BF G40574BA G08918WF G00912UN G48414YA G25418HZ G27058EU G59626AS G80920RR G62765YT G10486CT G28681TP	GlycoProtDB UniProt GlyGen GlyConnect
290	N-linked (GlcNAc...) asparagine	37074911	G72951AH G57776ZS G34989PA G85554PZ G49642SA G58087IP G27126ED G37509XX G49018RC	UniProt GlyGen
333	N-linked (GlcNAc...) asparagine	16335952 17027507 19159218 29391424 29741879 37074911	G70232NH G06247RL G94470IW G81263BG G45395BF G08918WF G00912UN G48414YA	GlycoProtDB UniProt GlyGen GlyConnect
467	N-linked (GlcNAc...) asparagine	16335952 17027507 29391424	G11629QQ G14796IU	GlycoProtDB UniProt GlyGen GlyConnect
471	N-linked (GlcNAc...) asparagine	16335952		GlycoProtDB UniProt GlyGen
621	N-linked (GlcNAc...) asparagine	16335952 17027507 29391424 29741879 37074911	G40206WX G48414YA G01650EU G23294PN G70101JE G80920RR G37399XV G82463GQ G62765YT G05724UK G31852PQ G39188ZX G41247ZX G02815KT G06110VR	GlycoProtDB UniProt GlyGen GlyConnect
651	N-linked (GlcNAc...) (complex) asparagine	16335952 17234210 29391424 29671580 29741879 37074911	G56518TU G78649WQ G70232NH G70888PK G06247RL G11629QQ G22310AV G45395BF G02030ZB G12580WI G40574BA G82830MN G08918WF G75983OB G00912UN G48414YA G27058EU G83460ZZ G06356OH G59626AS G80920RR G62765YT G10486CT G95865ZB G57776ZU	GlycoProtDB UniProt GlyGen GlyConnect
703		29391424	G48414YA	GlyGen GlyConnect

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 3** entries
Pathway Name	Organism
Activation of C3 and C5	Homo sapiens
Initial triggering of complement	Homo sapiens
Regulation of Complement cascade	Homo sapiens

Disease

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0110026	age related macular degeneration 14	Alliance of Genome Resources
DOID:4448	macular degeneration	Alliance of Genome Resources
DOID:8893	psoriasis	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:0060295	complement component 2 deficiency	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements