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Kallikrein-1

Summary

UniProt ID: P06870
Gene Symbol: KLK1
Gene ID: 3816
Organism: Homo sapiens (human)

External Links

GlyConnect

Glandular kallikrein 1

GlyGen

P06870

PubChem

P06870

The Human Metabolome Database

HMDBP13675

Re-Glyco

P06870

Annotation

Keyword: 3D-structure Alternative splicing Direct protein sequencing Disulfide bond Glycoprotein Proteomics identification Reference proteome Serine protease Signal Zymogen

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	Reference
regulation of systemic arterial blood pressure	IBA	GO_REF
zymogen activation	IBA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

zymogen activation

protein maturation [inference]

protein processing [inference]

zymogen activation

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

zymogen activation

protein maturation [inference]

protein processing [inference]

zymogen activation

biological regulation [inference]

regulation of biological quality [inference]

regulation of blood pressure [inference]

regulation of systemic arterial blood pressure

Displaying **all 4** entries
GO Term	Evidence Code	Reference
obsolete extracellular space
nucleus	IDA	PMID
secretory granule	IBA	GO_REF
extracellular exosome	HDA	PMID

GO Hierarchy

cellular component

cellular anatomical structure [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 4** entries
GO Term	Evidence Code	Reference
serine-type endopeptidase activity	NAS	PMID
serine-type endopeptidase activity	TAS	PMID
serine-type endopeptidase activity	IBA	GO_REF
serine-type endopeptidase activity	IEA	GO_REF GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWVLTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHDLMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKILPNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNKPSVAVRVLSYVKWIEDTIAENS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 7** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
93	O-linked (GalNAc...) serine	3163150		UniProt GlyGen
102	N-linked (GlcNAc...) asparagine	3163150 8416919	G60963AS G63065KG G23484GM G29377XJ G20170YB G25350TT G09150LP G72221XM G59361OW G88948CY G85542KD G88417ED G09482NW G96063MG G88461FF	UniProt GlyGen
104	O-linked (GalNAc...) serine	3163150		UniProt GlyGen
108	N-linked (GlcNAc...) asparagine	15651049 3163150 8416919	G60963AS G63065KG G23484GM G29377XJ G20170YB G25350TT G09150LP G72221XM G59361OW G88948CY G85542KD G88417ED G09482NW G96063MG G88461FF	UniProt GlyGen
165	N-linked (GlcNAc...) asparagine; partial	3163150 8416919	G60963AS G63065KG G23484GM G29377XJ G20170YB G25350TT G09150LP G72221XM G59361OW G88948CY G85542KD G88417ED G09482NW G96063MG G88461FF	UniProt GlyGen
167	O-linked (GalNAc...) serine	3163150		UniProt GlyGen
unknown		8416919	G52358QA G60963AS G63065KG G86234IN G23484GM G25379SA G29377XJ G96416FQ G20170YB G25350TT G93683YO G09150LP G72221XM G89098OM G32332VU G59361OW G51640FO G88948CY G50757KG G85542KD G03382KH G88417ED G09482NW G14260UH G23432EQ G96063MG G10256JP G88461FF	GlyGen GlyConnect

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 2** entries
Pathway Name	Organism
Developmental Lineage of Pancreatic Acinar Cells	Homo sapiens
Regulation of IGF Activity by IGFBP	Homo sapiens

Disease

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:784	chronic kidney disease	Alliance of Genome Resources
DOID:5844	myocardial infarction	Alliance of Genome Resources
DOID:783	end stage renal disease	Alliance of Genome Resources
DOID:0050700	cardiomyopathy	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements