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Complement factor H

Summary

UniProt ID: P06909
Gene Symbol: Cfh Hf1
Gene ID: 12628
Organism: Mus musculus (house mouse)

External Links

GlycoProtDB

GPDB0003299

GlyConnect

Complement factor h

GlyGen

P06909

PubChem

P06909

Re-Glyco

P06909

Annotation

Keyword: 3D-structure Complement alternate pathway Disulfide bond Glycoprotein Phosphoprotein Reference proteome Repeat Secreted Signal Sulfation Sushi

Gene Ontology (GO)

Displaying entries **1 - 5** of 52 in total

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GO Term	Evidence Code	Reference
angiogenesis	IMP	PMID
neutrophil homeostasis	IGI	PMID
kidney development	IMP	PMID
kidney development	IGI	PMID
activation of membrane attack complex	IMP	PMID

GO Hierarchy

biological process

immune system process [inference]

leukocyte homeostasis [inference]

neutrophil homeostasis

immune effector process [inference]

immune complex clearance

leukocyte mediated immunity [inference]

lymphocyte mediated immunity [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response

complement activation

activation of immune response [inference]

complement activation

myeloid cell homeostasis [inference]

neutrophil homeostasis

immune response

adaptive immune response [inference]

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response

organ or tissue specific immune response

humoral immune response [inference]

complement activation

innate immune response [inference]

complement activation, alternative pathway

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion [inference]

leukocyte cell-cell adhesion [inference]

leukocyte aggregation [inference]

monocyte aggregation

homotypic cell-cell adhesion [inference]

platelet aggregation

metabolic process [inference]

phosphorus metabolic process [inference]

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

nucleoside triphosphate metabolic process [inference]

purine nucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

mitochondrial gene expression

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

mitochondrial gene expression

protein metabolic process [inference]

proteolysis

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

mitochondrial DNA metabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

nucleoside triphosphate metabolic process [inference]

purine nucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

mitochondrial DNA metabolic process

protein metabolic process [inference]

proteolysis

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

nucleoside triphosphate metabolic process [inference]

purine nucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

carbohydrate derivative metabolic process [inference]

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation [inference]

photoreceptor cell differentiation

muscle cell differentiation [inference]

smooth muscle cell differentiation [inference]

vascular associated smooth muscle cell differentiation

cell development [inference]

neuron development [inference]

photoreceptor cell development [inference]

eye photoreceptor cell development [inference]

retinal rod cell development

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to lipid [inference]

cellular response to lipopolysaccharide

cellular response to oxygen-containing compound [inference]

cellular response to lipopolysaccharide

cellular response to biotic stimulus [inference]

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of light stimulus [inference]

visual perception

neuromuscular process

determination of adult lifespan

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

leukocyte homeostasis [inference]

neutrophil homeostasis

myeloid cell homeostasis [inference]

neutrophil homeostasis

energy homeostasis [inference]

response to dietary excess

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

anatomical structure development [inference]

cell development [inference]

neuron development [inference]

photoreceptor cell development [inference]

eye photoreceptor cell development [inference]

retinal rod cell development

animal gross anatomical part developmental process [inference]

tissue development [inference]

epithelium development [inference]

retinal pigment epithelium development

glomerulus development

animal organ development [inference]

retina development in camera-type eye

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation [inference]

photoreceptor cell differentiation

muscle cell differentiation [inference]

smooth muscle cell differentiation [inference]

vascular associated smooth muscle cell differentiation

cell development [inference]

neuron development [inference]

photoreceptor cell development [inference]

eye photoreceptor cell development [inference]

retinal rod cell development

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

leukocyte homeostasis [inference]

neutrophil homeostasis

myeloid cell homeostasis [inference]

neutrophil homeostasis

energy homeostasis [inference]

response to dietary excess

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

complement activation, alternative pathway

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

inflammatory response to wounding

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

complement activation, alternative pathway

response to wounding [inference]

inflammatory response to wounding

immune response

adaptive immune response [inference]

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response

organ or tissue specific immune response

humoral immune response [inference]

complement activation

innate immune response [inference]

complement activation, alternative pathway

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide [inference]

cellular response to lipopolysaccharide

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

complement activation, alternative pathway

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide [inference]

cellular response to lipopolysaccharide

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

complement activation, alternative pathway

cellular response to biotic stimulus [inference]

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

response to nutrient levels [inference]

response to dietary excess

response to chemical [inference]

response to lipid [inference]

response to lipopolysaccharide [inference]

cellular response to lipopolysaccharide

cellular response to lipid [inference]

cellular response to lipopolysaccharide

cellular response to chemical stimulus [inference]

cellular response to lipid [inference]

cellular response to lipopolysaccharide

cellular response to oxygen-containing compound [inference]

cellular response to lipopolysaccharide

response to peptide [inference]

response to cytokine

response to oxygen-containing compound [inference]

response to lipopolysaccharide [inference]

cellular response to lipopolysaccharide

cellular response to oxygen-containing compound [inference]

cellular response to lipopolysaccharide

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to lipid [inference]

cellular response to lipopolysaccharide

cellular response to oxygen-containing compound [inference]

cellular response to lipopolysaccharide

cellular response to biotic stimulus [inference]

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

regulation of immune effector process [inference]

regulation of complement activation

regulation of complement activation, alternative pathway

regulation of immune response [inference]

regulation of humoral immune response [inference]

regulation of complement activation

regulation of complement activation, alternative pathway

regulation of innate immune response [inference]

regulation of complement activation, alternative pathway

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

regulation of innate immune response [inference]

regulation of complement activation, alternative pathway

regulation of response to external stimulus [inference]

regulation of innate immune response [inference]

regulation of complement activation, alternative pathway

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

regulation of immune response [inference]

regulation of humoral immune response [inference]

regulation of complement activation

regulation of complement activation, alternative pathway

regulation of innate immune response [inference]

regulation of complement activation, alternative pathway

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of innate immune response [inference]

regulation of complement activation, alternative pathway

regulation of cellular process [inference]

regulation of cell killing [inference]

regulation of complement-dependent cytotoxicity

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	Reference
extracellular region	ISS	GO_REF
extracellular region	ISO	GO_REF
extracellular region	IDA	PMID PMID PMID
extracellular region	IEA	GO_REF GO_REF
extracellular region	HDA	PMID

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

peptidase complex [inference]

serine-type peptidase complex [inference]

serine-type endopeptidase complex

endopeptidase complex [inference]

serine-type endopeptidase complex

cellular anatomical structure [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

other organism part [inference]

symbiont cell surface

cell body [inference]

neuronal cell body

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	Reference
complement component C3b binding	IBA	GO_REF
complement component C3b binding	IPI	PMID PMID
heparin binding	ISO	GO_REF
heparin binding	IDA	PMID PMID
heparin binding	IEA	GO_REF

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

opsonin binding [inference]

complement component C3b binding

complement binding [inference]

complement component C3b binding

identical protein binding

proteoglycan binding [inference]

heparan sulfate proteoglycan binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

proteoglycan binding [inference]

heparan sulfate proteoglycan binding

sulfur compound binding [inference]

heparin binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MRLSARIIWLILWTVCAAEDCKGPPPRENSEILSGSWSEQLYPEGTQATYKCRPGYRTLGTIVKVCKNGKWVASNPSRICRKKPCGHPGDTPFGSFRLAVGSQFEFGAKVVYTCDDGYQLLGEIDYRECGADGWINDIPLCEVVKCLPVTELENGRIVSGAAETDQEYYFGQVVRFECNSGFKIEGHKEIHCSENGLWSNEKPRCVEILCTPPRVENGDGINVKPVYKENERYHYKCKHGYVPKERGDAVCTGSGWSSQPFCEEKRCSPPYILNGIYTPHRIIHRSDDEIRYECNYGFYPVTGSTVSKCTPTGWIPVPRCTLKPCEFPQFKYGRLYYEESLRPNFPVSIGNKYSYKCDNGFSPPSGYSWDYLRCTAQGWEPEVPCVRKCVFHYVENGDSAYWEKVYVQGQSLKVQCYNGYSLQNGQDTMTCTENGWSPPPKCIRIKTCSASDIHIDNGFLSESSSIYALNRETSYRCKQGYVTNTGEISGSITCLQNGWSPQPSCIKSCDMPVFENSITKNTRTWFKLNDKLDYECLVGFENEYKHTKGSITCTYYGWSDTPSCYERECSVPTLDRKLVVSPRKEKYRVGDLLEFSCHSGHRVGPDSVQCYHFGWSPGFPTCKGQVASCAPPLEILNGEINGAKKVEYSHGEVVKYDCKPRFLLKGPNKIQCVDGNWTTLPVCIEEERTCGDIPELEHGSAKCSVPPYHHGDSVEFICEENFTMIGHGSVSCISGKWTQLPKCVATDQLEKCRVLKSTGIEAIKPKLTEFTHNSTMDYKCRDKQEYERSICINGKWDPEPNCTSKTSCPPPPQIPNTQVIETTVKYLDGEKLSVLCQDNYLTQDSEEMVCKDGRWQSLPRCIEKIPCSQPPTIEHGSINLPRSSEERRDSIESSSHEHGTTFSYVCDDGFRIPEENRITCYMGKWSTPPRCVGLPCGPPPSIPLGTVSLELESYQHGEEVTYHCSTGFGIDGPAFIICEGGKWSDPPKCIKTDCDVLPTVKNAIIRGKSKKSYRTGEQVTFRCQSPYQMNGSDTVTCVNSRWIGQPVCKDNSCVDPPHVPNATIVTRTKNKYLHGDRVRYECNKPLELFGQVEVMCENGIWTEKPKCRDSTGKCGPPPPIDNGDITSLSLPVYEPLSSVEYQCQKYYLLKGKKTITCRNGKWSEPPTCLHACVIPENIMESHNIILKWRHTEKIYSHSGEDIEFGCKYGYYKARDSPPFRTKCINGTINYPTCV

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 7** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
676	N-linked (GlcNAc...) asparagine			GlycoProtDB UniProt GlyGen
721	N-linked (GlcNAc...) asparagine			UniProt GlyGen
773	N-linked (GlcNAc...) asparagine	16944957 17330941	G57471MV G44437FL G72747WU G02281EI G13749ZZ	GlycoProtDB UniProt GlyGen
801	N-linked (GlcNAc...) asparagine	17330941 20571061	G15569GG G40608DF G80920RR	GlycoProtDB UniProt GlyGen GlyConnect
1030	N-linked (GlcNAc...) asparagine	17330941	G41071NU	GlycoProtDB UniProt GlyGen
1061	N-linked (GlcNAc...) asparagine	16944957 17330941 20571061	G15488CF G39397SW G15569GG G40608DF G40574BA	GlycoProtDB UniProt GlyGen GlyConnect
1225	N-linked (GlcNAc...) asparagine	17330941	G80920RR	GlycoProtDB UniProt GlyGen