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Acetylcholinesterase

Summary

UniProt ID: P07140
Gene Symbol: Ace CG17907
Gene ID: 41625
Organism: Drosophila melanogaster (fruit fly)

External Links

GlyGen: P07140
PubChem: P07140
Re-Glyco: P07140

Annotation

Keyword: 3D-structure Cell membrane Direct protein sequencing Disulfide bond GPI-anchor Neurotransmitter degradation Reference proteome Serine esterase Signal Synapse

Gene Ontology (GO)

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GO Term	Evidence Code	Reference
acetylcholine catabolic process in synaptic cleft	IEA	GO_REF
acetylcholine catabolic process	IDA	PMID
acetylcholine catabolic process	IMP	PMID
acetylcholine catabolic process	IBA	GO_REF
chemical synaptic transmission	IMP	PMID

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

metabolic process [inference]

acetylcholine metabolic process [inference]

acetylcholine catabolic process

acetylcholine catabolic process in synaptic cleft

catabolic process [inference]

acetylcholine catabolic process

acetylcholine catabolic process in synaptic cleft

amine catabolic process [inference]

biogenic amine catabolic process [inference]

choline catabolic process

amine metabolic process [inference]

amine catabolic process [inference]

biogenic amine catabolic process [inference]

choline catabolic process

choline metabolic process

choline catabolic process

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

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GO Term	Evidence Code	Reference
obsolete extracellular space
cytoplasm	IDA	PMID
plasma membrane	IDA	PMID
plasma membrane	IBA	GO_REF
plasma membrane	IEA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytoplasm

membrane [inference]

plasma membrane

cell junction [inference]

synapse

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GO Term	Evidence Code	Reference
acetylcholinesterase activity	IDA	PMID
acetylcholinesterase activity	IMP	PMID PMID
acetylcholinesterase activity	IBA	GO_REF
acetylcholinesterase activity	IEA	GO_REF GO_REF GO_REF
cholinesterase activity	IDA	PMID

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

carboxylic ester hydrolase activity [inference]

cholinesterase activity

acetylcholinesterase activity

serine hydrolase activity

binding [inference]

protein binding [inference]

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

sulfate binding

sulfur compound binding [inference]

sulfate binding

Gene Ontology information from UniProt.

Site Annotations

Displaying 1 entry
Position	Description
569	Not glycosylated

Annotation information from UniProt.

Sequence

MAISCRQSRVLPMSLPLPLTIPLPLVLVLSLHLSGVCGVIDRLVVQTSSGPVRGRSVTVQGREVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATRLSATCVQERYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHPNGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLKTNPAHVMSCMRSVDAKTISVQQWNSYSGILSFPSAPTIDGAFLPADPMTLMKTADLKDYDILMGNVRDEGTYFLLYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAEREAIIFQYTSWEGNPGYQNQQQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYFTHRTSTSLWGEWMGVLHGDEIEYFFGQPLNNSLQYRPVERELGKRMLSAVIEFAKTGNPAQDGEEWPNFSKEDPVYYIFSTDDKIEKLARGPLAARCSFWNDYLPKVRSWAGTCDGDSGSASISPRLQLLGIAALIYICAALRTKRVF

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	Description	PubMed ID	Source
126	N-linked (GlcNAc...) asparagine	1730712	UniProt GlyGen
174	N-linked (GlcNAc...) asparagine	1730712	UniProt GlyGen
331	N-linked (GlcNAc...) asparagine	1730712	UniProt GlyGen
531	N-linked (GlcNAc...) asparagine	1730712	UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 3** entries
Pathway Name	Organism
Aspirin ADME	Drosophila melanogaster
Neurotransmitter clearance	Drosophila melanogaster
Synthesis of PC	Drosophila melanogaster

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Acknowledgements