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Ribonucleoside-diphosphate reductase large subunit

Summary

UniProt ID: P07742
Gene Symbol: Rrm1
Gene ID: 20133
Organism: Mus musculus (house mouse)

External Links

GlyGen: P07742
PubChem: P07742
O-GlcNAcAtlas: P07742
Re-Glyco: P07742

Annotation

Keyword: ATP-binding Acetylation Allosteric enzyme Cytoplasm Deoxyribonucleotide synthesis Disulfide bond Oxidoreductase Phosphoprotein Reference proteome

Gene Ontology (GO)

Displaying entries **1 - 5** of 28 in total

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GO Term	Evidence Code	Reference
DNA synthesis involved in DNA repair	NAS	PMID
pyrimidine nucleobase metabolic process
mitochondrial DNA replication	ISO	GO_REF
mitochondrial DNA replication	IMP	PMID
mitochondrial DNA replication	IEA	GO_REF GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

nucleotide biosynthetic process [inference]

2'-deoxyribonucleotide biosynthetic process

2'-deoxyribonucleotide metabolic process [inference]

2'-deoxyribonucleotide biosynthetic process

nucleoside diphosphate metabolic process [inference]

ribonucleoside diphosphate metabolic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

2'-deoxyribonucleotide biosynthetic process

deoxyribose phosphate biosynthetic process [inference]

2'-deoxyribonucleotide biosynthetic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

nucleotide biosynthetic process [inference]

2'-deoxyribonucleotide biosynthetic process

2'-deoxyribonucleotide metabolic process [inference]

2'-deoxyribonucleotide biosynthetic process

nucleoside diphosphate metabolic process [inference]

ribonucleoside diphosphate metabolic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

2'-deoxyribonucleotide biosynthetic process

organophosphate biosynthetic process [inference]

deoxyribose phosphate biosynthetic process [inference]

2'-deoxyribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

2'-deoxyribonucleotide biosynthetic process

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

deoxyribonucleotide biosynthetic process

nucleobase-containing compound biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

2'-deoxyribonucleotide biosynthetic process

organophosphate biosynthetic process [inference]

deoxyribose phosphate biosynthetic process [inference]

2'-deoxyribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

2'-deoxyribonucleotide biosynthetic process

carbohydrate derivative biosynthetic process [inference]

deoxyribose phosphate biosynthetic process [inference]

2'-deoxyribonucleotide biosynthetic process

deoxyribonucleotide metabolic process [inference]

deoxyribonucleotide biosynthetic process

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication [inference]

DNA-templated DNA replication [inference]

mitochondrial DNA replication

DNA repair

mitochondrial DNA metabolic process [inference]

mitochondrial DNA replication

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

nucleic acid biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

2'-deoxyribonucleotide biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

nucleotide biosynthetic process [inference]

2'-deoxyribonucleotide biosynthetic process

2'-deoxyribonucleotide metabolic process [inference]

2'-deoxyribonucleotide biosynthetic process

nucleoside diphosphate metabolic process [inference]

ribonucleoside diphosphate metabolic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

2'-deoxyribonucleotide biosynthetic process

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication [inference]

DNA-templated DNA replication [inference]

mitochondrial DNA replication

DNA repair

mitochondrial DNA metabolic process [inference]

mitochondrial DNA replication

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

nucleic acid biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

nucleotide biosynthetic process [inference]

2'-deoxyribonucleotide biosynthetic process

2'-deoxyribonucleotide metabolic process [inference]

2'-deoxyribonucleotide biosynthetic process

nucleoside diphosphate metabolic process [inference]

ribonucleoside diphosphate metabolic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

2'-deoxyribonucleotide biosynthetic process

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process

pyrimidine-containing compound metabolic process [inference]

pyrimidine nucleobase metabolic process

carbohydrate derivative metabolic process [inference]

2'-deoxyribonucleotide metabolic process [inference]

2'-deoxyribonucleotide biosynthetic process

carbohydrate derivative biosynthetic process [inference]

deoxyribose phosphate biosynthetic process [inference]

2'-deoxyribonucleotide biosynthetic process

cell population proliferation [inference]

neural precursor cell proliferation [inference]

cell proliferation in forebrain

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein tetramerization [inference]

protein heterotetramerization

protein heterooligomerization [inference]

protein heterotetramerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein tetramerization [inference]

protein heterotetramerization

protein heterooligomerization [inference]

protein heterotetramerization

reproductive process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

male gonad development

developmental process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

male gonad development

anatomical structure development [inference]

animal organ development [inference]

gonad development [inference]

male gonad development

reproductive structure development [inference]

gonad development [inference]

male gonad development

retina development in camera-type eye

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

response to abiotic stimulus [inference]

response to radiation [inference]

response to ionizing radiation

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of cell cycle process [inference]

positive regulation of G0 to G1 transition

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of cell cycle G2/M phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of cell cycle G1/S phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of cell cycle process [inference]

positive regulation of G0 to G1 transition

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of cell cycle G2/M phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of cell cycle G1/S phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle phase transition [inference]

regulation of mitotic cell cycle phase transition [inference]

regulation of G2/M transition of mitotic cell cycle [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of mitotic cell cycle phase transition [inference]

regulation of G1/S transition of mitotic cell cycle [inference]

positive regulation of G1/S transition of mitotic cell cycle

regulation of cell cycle process [inference]

regulation of G0 to G1 transition [inference]

positive regulation of G0 to G1 transition

positive regulation of cell cycle process [inference]

positive regulation of G0 to G1 transition

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of cell cycle G2/M phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of cell cycle G1/S phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

regulation of cell cycle phase transition [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of cell cycle G2/M phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of cell cycle G1/S phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

regulation of mitotic cell cycle phase transition [inference]

regulation of G2/M transition of mitotic cell cycle [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of mitotic cell cycle phase transition [inference]

regulation of G1/S transition of mitotic cell cycle [inference]

positive regulation of G1/S transition of mitotic cell cycle

regulation of cell cycle G2/M phase transition [inference]

regulation of G2/M transition of mitotic cell cycle [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of cell cycle G2/M phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

regulation of cell cycle G1/S phase transition [inference]

positive regulation of cell cycle G1/S phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

regulation of G1/S transition of mitotic cell cycle [inference]

positive regulation of G1/S transition of mitotic cell cycle

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of cell cycle process [inference]

positive regulation of G0 to G1 transition

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of cell cycle G2/M phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of cell cycle G1/S phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	Reference
nuclear envelope	ISO	GO_REF
mitochondrion	IEA	GO_REF
cytosol	ISO	GO_REF
cytosol	IEA	GO_REF
ribonucleoside-diphosphate reductase complex	ISS	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

oxidoreductase complex [inference]

ribonucleoside-diphosphate reductase complex

cellular anatomical structure [inference]

microtubule organizing center [inference]

ciliary basal body

cytosol

organelle envelope [inference]

nuclear envelope

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

cell body [inference]

neuronal cell body

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	Reference
ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	IDA	PMID PMID
ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	IBA	GO_REF
ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	IEA	GO_REF GO_REF GO_REF
ATP binding	IBA	GO_REF
ATP binding	IEA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on CH or CH2 groups [inference]

oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor [inference]

ribonucleoside-diphosphate reductase activity

ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor

binding [inference]

protein binding [inference]

protein domain specific binding [inference]

disordered domain specific binding

identical protein binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MHVIKRDGRQERVMFDKITSRIQKLCYGLNMDFVDPAQITMKVIQGLYSGVTTVELDTLAAETAATLTTKHPDYAILAARIAVSNLHKETKKVFSDVMEDLYNYINPHNGRHSPMVASSTLDIVMANKDRLNSAIIYDRDFSYNYFGFKTLERSYLLKINGKVAERPQHMLMRVSVGIHKEDIDAAIETYNLLSEKWFTHASPTLFNAGTNRPQLSSCFLLSMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYESYEKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTPEHTYDFEKLAEVTKVIVRNLNKIIDINYYPIPEAHLSNKRHRPIGIGVQGLADAFILMRYPFESPEAQLLNKQIFETIYYGALEASCELAKEYGPYETYEGSPVSKGILQYDMWNVAPTDLWDWKPLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWNEEMKNQIIACNGSIQSIPEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTGMYYLRTRPAANPIQFTLNKEKLKDKEKALKEEEEKERNTAAMVCSLENREECLMCGS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites