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MAP kinase kinase PBS2

Summary

UniProt ID: P08018
Gene Symbol: HOG4 J0699 PBS2 SFS4 SSK4 YJL128C
Gene ID: 853313
Organism: Saccharomyces cerevisiae S288C

External Links

GlyGen: P08018
PubChem: P08018
O-GlcNAcAtlas: P08018
Re-Glyco: P08018

Annotation

Keyword: 3D-structure ATP-binding Antibiotic resistance Cytoplasm Phosphoprotein Reference proteome Serine/threonine-protein kinase Tyrosine-protein kinase

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	Reference
MAPK cascade	IBA	GO_REF
protein phosphorylation	IDA	PMID
protein import into nucleus	IMP	PMID
hyperosmotic response	IMP	PMID
actin filament organization	IMP	PMID

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

osmosensory signaling pathway

osmosensory signaling pathway via Sho1 osmosensor

intracellular signaling cassette [inference]

MAPK cascade

p38MAPK cascade

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

intercellular transport [inference]

import into nucleus [inference]

protein import into nucleus

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

protein import into nucleus

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

osmosensory signaling pathway

osmosensory signaling pathway via Sho1 osmosensor

cellular hyperosmotic response

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

osmosensory signaling pathway

osmosensory signaling pathway via Sho1 osmosensor

cellular hyperosmotic response

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to osmotic stress [inference]

osmosensory signaling pathway

osmosensory signaling pathway via Sho1 osmosensor

cellular hyperosmotic response

cellular component organization or biogenesis [inference]

cellular component organization [inference]

supramolecular fiber organization [inference]

actin filament organization

response to stimulus [inference]

response to stress [inference]

response to osmotic stress [inference]

hyperosmotic response

cellular hyperosmotic response

cellular response to osmotic stress [inference]

osmosensory signaling pathway

osmosensory signaling pathway via Sho1 osmosensor

cellular hyperosmotic response

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

osmosensory signaling pathway

osmosensory signaling pathway via Sho1 osmosensor

cellular hyperosmotic response

response to abiotic stimulus [inference]

response to osmotic stress [inference]

hyperosmotic response

cellular hyperosmotic response

cellular response to osmotic stress [inference]

osmosensory signaling pathway

osmosensory signaling pathway via Sho1 osmosensor

cellular hyperosmotic response

cellular response to abiotic stimulus [inference]

cellular response to osmotic stress [inference]

osmosensory signaling pathway

osmosensory signaling pathway via Sho1 osmosensor

cellular hyperosmotic response

response to chemical [inference]

response to antibiotic

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

osmosensory signaling pathway

osmosensory signaling pathway via Sho1 osmosensor

cellular hyperosmotic response

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

osmosensory signaling pathway

osmosensory signaling pathway via Sho1 osmosensor

cellular hyperosmotic response

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

osmosensory signaling pathway

osmosensory signaling pathway via Sho1 osmosensor

cellular hyperosmotic response

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to osmotic stress [inference]

osmosensory signaling pathway

osmosensory signaling pathway via Sho1 osmosensor

cellular hyperosmotic response

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

protein localization to organelle [inference]

protein localization to nucleus [inference]

protein import into nucleus

establishment of localization [inference]

transport [inference]

intercellular transport [inference]

import into nucleus [inference]

protein import into nucleus

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

protein import into nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

protein import into nucleus

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

protein import into nucleus

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

osmosensory signaling pathway

osmosensory signaling pathway via Sho1 osmosensor

intracellular signaling cassette [inference]

MAPK cascade

p38MAPK cascade

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy

regulation of autophagy [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy

regulation of macroautophagy [inference]

positive regulation of macroautophagy

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	Reference
cytoplasm	IDA	PMID
cytoplasm	IEA	GO_REF GO_REF
cellular bud tip	IDA	PMID
cellular bud neck	IDA	PMID
cytoplasmic stress granule	HDA	PMID

GO Hierarchy

cellular component

protein-containing complex [inference]

intracellular protein-containing complex [inference]

protein acetyltransferase complex [inference]

N-terminal protein acetyltransferase complex [inference]

NatB complex

catalytic complex [inference]

transferase complex [inference]

acetyltransferase complex [inference]

protein acetyltransferase complex [inference]

N-terminal protein acetyltransferase complex [inference]

NatB complex

cellular anatomical structure [inference]

cytoplasm

site of polarized growth [inference]

organelle [inference]

membraneless organelle [inference]

intracellular membraneless organelle [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

cytoplasmic stress granule

intracellular organelle [inference]

intracellular membraneless organelle [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

cytoplasmic stress granule

supramolecular complex [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

cytoplasmic stress granule

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	Reference
protein-N-terminal amino-acid acetyltransferase activity	IMP	PMID
protein kinase activity	IEA	GO_REF
protein kinase activity	HDA	PMID
protein serine/threonine kinase activity
MAP kinase kinase activity	ISS	PMID

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

acyltransferase activity, transferring groups other than amino-acyl groups [inference]

acetyltransferase activity [inference]

N-acetyltransferase activity [inference]

protein N-acetyltransferase activity [inference]

protein-N-terminal amino-acid acetyltransferase activity

N-acyltransferase activity [inference]

N-acetyltransferase activity [inference]

protein N-acetyltransferase activity [inference]

protein-N-terminal amino-acid acetyltransferase activity

protein N-acyltransferase activity [inference]

protein N-acetyltransferase activity [inference]

protein-N-terminal amino-acid acetyltransferase activity

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine/tyrosine kinase activity [inference]

MAP kinase kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine/tyrosine kinase activity [inference]

MAP kinase kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine/tyrosine kinase activity [inference]

MAP kinase kinase activity

protein N-acyltransferase activity [inference]

protein N-acetyltransferase activity [inference]

protein-N-terminal amino-acid acetyltransferase activity

structural molecule activity [inference]

protein complex scaffold activity [inference]

MAP kinase scaffold activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

signaling adaptor activity [inference]

MAP kinase scaffold activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MEDKFANLSLHEKTGKSSIQLNEQTGSDNGSAVKRTSSTSSHYNNINADLHARVKAFQEQRALKRSASVGSNQSEQDKGSSQSPKHIQQIVNKPLPPLPVAGSSKVSQRMSSQVVQASSKSTLKNVLDNQETQNITDVNINIDTTKITATTIGVNTGLPATDITPSVSNTASATHKAQLLNPNRRAPRRPLSTQHPTRPNVAPHKAPAIINTPKQSLSARRGLKLPPGGMSLKMPTKTAQQPQQFAPSPSNKKHIETLSNSKVVEGKRSNPGSLINGVQSTSTSSSTEGPHDTVGTTPRTGNSNNSSNSGSSGGGGLFANFSKYVDIKSGSLNFAGKLSLSSKGIDFSNGSSSRITLDELEFLDELGHGNYGNVSKVLHKPTNVIMATKEVRLELDEAKFRQILMELEVLHKCNSPYIVDFYGAFFIEGAVYMCMEYMDGGSLDKIYDESSEIGGIDEPQLAFIANAVIHGLKELKEQHNIIHRDVKPTNILCSANQGTVKLCDFGVSGNLVASLAKTNIGCQSYMAPERIKSLNPDRATYTVQSDIWSLGLSILEMALGRYPYPPETYDNIFSQLSAIVDGPPPRLPSDKFSSDAQDFVSLCLQKIPERRPTYAALTEHPWLVKYRNQDVHMSEYITERLERRNKILRERGENGLSKNVPALHMGGL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
156			G49108TO	GlyGen
269			G49108TO	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 5** entries
Pathway Name	Organism
FCERI mediated MAPK activation	Saccharomyces cerevisiae
NOD1/2 Signaling Pathway	Saccharomyces cerevisiae
Oxidative Stress Induced Senescence	Saccharomyces cerevisiae
PI5P Regulates TP53 Acetylation	Saccharomyces cerevisiae
activated TAK1 mediates p38 MAPK activation	Saccharomyces cerevisiae

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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