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Repository for lectin-assisted multimodality data
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MIRAGE
Collagen alpha-2(I) chain
Summary
- UniProt ID
- P08123
- Gene Symbol
- COL1A2
- Gene ID
- 1278
- Organism
- Homo sapiens (human)
External Links
- GlyConnect
- GlyGen
- P08123
- PubChem
- P08123
- The Human Metabolome Database
- HMDBP01758
- RaftProt
- P08123
- Re-Glyco
- P08123
Annotation
- Keyword
- 3D-structure Calcium Chromosomal rearrangement Collagen Direct protein sequencing Disease variant Disulfide bond Dwarfism Ehlers-Danlos syndrome Extracellular matrix Glycoprotein Hydroxylation Metal-binding Osteogenesis imperfecta Proteomics identification Pyrrolidone carboxylic acid Reference proteome Repeat Signal
Gene Ontology (GO)
| GO Term | Evidence Code | Reference |
|---|---|---|
| skeletal system development | ||
| skeletal system development | ||
| blood vessel development | ||
| transforming growth factor beta receptor signaling pathway | ||
| Rho protein signal transduction |
GO Hierarchy
| GO Term | Evidence Code | Reference |
|---|---|---|
| protease binding | ||
| extracellular matrix structural constituent | ||
| extracellular matrix structural constituent | ||
| extracellular matrix structural constituent conferring tensile strength | ||
| extracellular matrix structural constituent conferring tensile strength |
GO Hierarchy
Sequence
MLSFVDTRTLLLLAVTLCLATCQSLQEETVRKGPAGDRGPRGERGPPGPPGRDGEDGPTGPPGPPGPPGPPGLGGNFAAQYDGKGVGLGPGPMGLMGPRGPPGAAGAPGPQGFQGPAGEPGEPGQTGPAGARGPAGPPGKAGEDGHPGKPGRPGERGVVGPQGARGFPGTPGLPGFKGIRGHNGLDGLKGQPGAPGVKGEPGAPGENGTPGQTGARGLPGERGRVGAPGPAGARGSDGSVGPVGPAGPIGSAGPPGFPGAPGPKGEIGAVGNAGPAGPAGPRGEVGLPGLSGPVGPPGNPGANGLTGAKGAAGLPGVAGAPGLPGPRGIPGPVGAAGATGARGLVGEPGPAGSKGESGNKGEPGSAGPQGPPGPSGEEGKRGPNGEAGSAGPPGPPGLRGSPGSRGLPGADGRAGVMGPPGSRGASGPAGVRGPNGDAGRPGEPGLMGPRGLPGSPGNIGPAGKEGPVGLPGIDGRPGPIGPAGARGEPGNIGFPGPKGPTGDPGKNGDKGHAGLAGARGAPGPDGNNGAQGPPGPQGVQGGKGEQGPPGPPGFQGLPGPSGPAGEVGKPGERGLHGEFGLPGPAGPRGERGPPGESGAAGPTGPIGSRGPSGPPGPDGNKGEPGVVGAVGTAGPSGPSGLPGERGAAGIPGGKGEKGEPGLRGEIGNPGRDGARGAPGAVGAPGPAGATGDRGEAGAAGPAGPAGPRGSPGERGEVGPAGPNGFAGPAGAAGQPGAKGERGAKGPKGENGVVGPTGPVGAAGPAGPNGPPGPAGSRGDGGPPGMTGFPGAAGRTGPPGPSGISGPPGPPGPAGKEGLRGPRGDQGPVGRTGEVGAVGPPGFAGEKGPSGEAGTAGPPGTPGPQGLLGAPGILGLPGSRGERGLPGVAGAVGEPGPLGIAGPPGARGPPGAVGSPGVNGAPGEAGRDGNPGNDGPPGRDGQPGHKGERGYPGNIGPVGAAGAPGPHGPVGPAGKHGNRGETGPSGPVGPAGAVGPRGPSGPQGIRGDKGEPGEKGPRGLPGLKGHNGLQGLPGIAGHHGDQGAPGSVGPAGPRGPAGPSGPAGKDGRTGHPGTVGPAGIRGPQGHQGPAGPPGPPGPPGPPGVSGGGYDFGYDGDFYRADQPRSAPSLRPKDYEVDATLKSLNNQIETLLTPEGSRKNPARTCRDLRLSHPEWSSGYYWIDPNQGCTMDAIKVYCDFSTGETCIRAQPENIPAKNWYRSSKDKKHVWLGETINAGSQFEYNVEGVTSKEMATQLAFMRLLANYASQNITYHCKNSIAYMDEETGNLKKAVILQGSNDVELVAEGNSRFTYTVLVDGCSKKTNEWGKTIIEYKTNKPSRLPFLDIAPLDIGGADQEFFVDIGPVCFK
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 59 |
|
|
||
| 170 |
|
|
||
| 177 |
|
|
||
| 501 |
|
|
||
| 603 |
|
|
||
| 632 |
|
|||
| 756 |
|
|
||
| 860 |
|
|||
| 1132 |
|
|||
| 1138 |
|
G43417UB
G57321FI
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Anchoring fibril formation | Homo sapiens |
| Assembly of collagen fibrils and other multimeric structures | Homo sapiens |
| Cell surface interactions at the vascular wall | Homo sapiens |
| Collagen biosynthesis and modifying enzymes | Homo sapiens |
| Collagen chain trimerization | Homo sapiens |
| Collagen degradation | Homo sapiens |
| Crosslinking of collagen fibrils | Homo sapiens |
| Defective VWF binding to collagen type I | Homo sapiens |
| Defective VWF cleavage by ADAMTS13 variant | Homo sapiens |
| Defective binding of VWF variant to GPIb:IX:V | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0110339 | osteogenesis imperfecta type 3 | |
| DOID:10941 | intracranial aneurysm | |
| DOID:13359 | Ehlers-Danlos syndrome | |
| DOID:0080728 | Ehlers-Danlos syndrome arthrochalasia type 2 | |
| DOID:4079 | heart valve disease | |
| DOID:12347 | osteogenesis imperfecta | |
| DOID:0110341 | osteogenesis imperfecta type 2 | |
| DOID:0080730 | Ehlers-Danlos syndrome cardiac valvular type | |
| DOID:0110340 | osteogenesis imperfecta type 4 | |
| DOID:11476 | osteoporosis |
