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Standards Ontologies Notations
Guidelines
MIRAGE
Interleukin-6 receptor subunit alpha

Summary
UniProt ID
P08887
Gene Symbol
  • IL6R
Gene ID
3570
Organism
Homo sapiens (human)
GlycoProtDB
GPDB0011451
GlyGen
P08887
PubChem
P08887
The O-GlcNAc Database
P08887
Re-Glyco
P08887
Annotation
Keyword
  • 3D-structure
  • Alternative splicing
  • Cell membrane
  • Direct protein sequencing
  • Disulfide bond
  • Glycoprotein
  • Immunoglobulin domain
  • Receptor
  • Reference proteome
  • Repeat
  • Secreted
  • Signal
  • Transmembrane helix
Gene Ontology (GO)
Displaying all 8 entries
GO Term
extracellular region
extracellular space
interleukin-6 receptor complex
ciliary neurotrophic factor receptor complex
plasma membrane
receptor complex
external side of plasma membrane
apical plasma membrane
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Site Annotations
Displaying 1 entry
Position Description
245 Not glycosylated
Annotation information from UniProt.
Sequence
MLAVGCALLAALLAAPGAALAPRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNATVHWVLRKPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYRAGRPAGTVHLLVDVPPEEPQLSCFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNSPAEDFQEPCQYSQESQKFSCQLAVPEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMGTPWTESRSPPAENEVSTPMQALTTNKDDDNILFRDSANATSLPVQDSSSVPLPTFLVAGGSLAFGTLLCIAIVLRFKKTWKLRALKEGKTSMHPPYSLGQLVPERPRPTPVLVPLISPPVSPSSLGSDNTSSHNRPDARDPRSPYDISNTDYFFPR
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying entries 1 - 10 of 12 in total
Position Description PubMed ID GlyTouCan ID Source
55 N-linked (GlcNAc...) asparagine
93 N-linked (GlcNAc...) asparagine
139
197
221 N-linked (GlcNAc...) asparagine
245 N-linked (GlcNAc...) asparagine
320
329
335
350 N-linked (GlcNAc...) asparagine
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying all 6 entries
Pathway Name Organism
Interleukin-4 and Interleukin-13 signaling Homo sapiens
Interleukin-6 signaling Homo sapiens
MAPK1 (ERK2) activation Homo sapiens
MAPK3 (ERK1) activation Homo sapiens
Potential therapeutics for SARS Homo sapiens
Transcriptional regulation of granulopoiesis Homo sapiens
Disease
Displaying all 5 entries
DO ID Disease Name Source
DOID:0080545 hyper IgE syndrome
DOID:10534 stomach cancer
DOID:10652 Alzheimer's disease
DOID:12858 Huntington's disease
DOID:9970 obesity
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025