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Kininogen-1 [Cleaved into: Kininogen-1 heavy chain; Bradykinin; Kininogen-1 light chain]
Summary
- UniProt ID
- P08934
- Gene Symbol
- Kng1 Kng
- Gene ID
- 25087
- Organism
- Rattus norvegicus (Norway rat)
Annotation
- Keyword
- Alternative splicing Blood coagulation Disulfide bond Glycoprotein Inflammatory response Phosphoprotein Reference proteome Repeat Secreted Signal Thiol protease inhibitor Vasodilator
Gene Ontology (GO)
| GO Term | Evidence Code | Reference |
|---|---|---|
| inflammatory response |
|
|
| negative regulation of cell adhesion | ||
| negative regulation of cell adhesion | ||
| blood coagulation |
|
|
| negative regulation of blood coagulation |
GO Hierarchy
| GO Term | Evidence Code | Reference |
|---|---|---|
| extracellular region | ||
| extracellular region |
| GO Term | Evidence Code | Reference |
|---|---|---|
| cysteine-type endopeptidase inhibitor activity | ||
| cysteine-type endopeptidase inhibitor activity |
GO Hierarchy
Sequence
MKLITILLLCSRLLPSLAQEEDAQEMDCNDESLFQAVDTALKKYNAGLKSGNQFVLYQVTEGTKKDGSKTFYSFKYQIKEGNCSVQSGFAWQDCDFKDAEEAATGECTATLEKRRNNKFSIATQICNITPGKGPIVTNEYHCLGCMHPISVDSPELGPVLKHAVEHFNNNTKHTHLFALGEVKSADRQVVAGMNYQIIYSIVQTNCSKEDFPSLHEDCVPLPSGDDGECKGNAFVDIHKTIAGFSDSCEFYPGDDLFELLPEDCPGCPRNIPVDSPELKEALGHSIAQLNAENNHTFYFKIDTVKKATSQVVAGTKYVIEFIARETKCSKESNAELTADCETKRLGQSLNCNANVYMRPWENKVVPTVKCKVLDMTSVIRRPPGFSPFRAPRVKKPKESTTVSPSYIARVQEERDPGNEQGPIHGHGWLHAKQIKNKNHQGHKHGHGIGHGHQKPHGLGHGHQLKLDDLKQQREDGYDHRHPVGHGHGQRHGHGHGHGHGRDKHTNKDKNNVKHTDQRRAPLTSSSEDNTTSTQIQGRTEGFTLNPPLAQPAVISRGFQDSGFTEGVIATTSPYDTETHDDLIPDIHVQPDSLSFKLISDFPEATSHKCPGRPWKPVSRKDPTIETTEFSDFDLLDALS
Glycosylation Sites
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| FXIIa activates plasma kallikrein-kinin system | Rattus norvegicus |
| FXIIa, PKa activate coagulation factors | Rattus norvegicus |
| G alpha (i) signalling events | Rattus norvegicus |
| G alpha (q) signalling events | Rattus norvegicus |
| Peptide ligand-binding receptors | Rattus norvegicus |
| Platelet degranulation | Rattus norvegicus |
| Post-translational protein phosphorylation | Rattus norvegicus |
| Regulation of FXIIa and plasma kallikrein activity | Rattus norvegicus |
| Regulation of IGF Activity by IGFBP | Rattus norvegicus |
