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Heat shock 70 kDa protein 1A

Summary

UniProt ID

P0DMW0

Gene Symbol

Hspa1a
Hsp70-1
Hspa1

Organism

Rattus norvegicus (Norway rat)

External Links

GlyGen: P0DMW0
The O-GlcNAc Database: P0DMW0

Annotation

Keyword

ATP-binding
Acetylation
Chaperone
Cytoskeleton
Methylation
Nucleus
Phosphoprotein
Reference proteome
Secreted
Stress response

Gene Ontology (GO)

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GO Term
positive regulation of microtubule nucleation
protein stabilization
chaperone cofactor-dependent protein refolding
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
negative regulation of transforming growth factor beta receptor signaling pathway
regulation of protein ubiquitination
negative regulation of protein ubiquitination
cellular response to heat
cellular response to unfolded protein
negative regulation of transcription by RNA polymerase II

Displaying entries **1 - 10** of 21 in total

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GO Term
ribonucleoprotein complex
inclusion body
aggresome
basolateral plasma membrane
apical plasma membrane
nuclear speck
mitochondrion
cytosol
membrane raft
zona pellucida receptor complex

Displaying entries **1 - 10** of 22 in total

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GO Term
misfolded protein binding
C3HC4-type RING finger domain binding
heat shock protein binding
denatured protein binding
ubiquitin protein ligase binding
protein folding chaperone
unfolded protein binding
ATP hydrolysis activity
receptor ligand activity
transcription regulator inhibitor activity

Annotation information from UniProt.

Sequence

MAKKTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVVNDGDKPKVQVNYKGENRSFYPEEISSMVLTKMKEIAEAYLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAERYKAEDEVQRERVAAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDSNTLAEKEEFVHKREELERVCNPIISGLYQGAGAPGAGGFGAQAPKGGSGSGPTIEEVD

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
			G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 7** entries
Pathway Name	Organism
AUF1 (hnRNP D0) binds and destabilizes mRNA	Rattus norvegicus
Attenuation phase	Rattus norvegicus
HSF1-dependent transactivation	Rattus norvegicus
HSP90 chaperone cycle for SHRs	Rattus norvegicus
Neutrophil degranulation	Rattus norvegicus
PKR-mediated signaling	Rattus norvegicus
Regulation of HSF1-mediated heat shock response	Rattus norvegicus