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Endothelin-converting enzyme 2

Summary

UniProt ID: P0DPD6
Gene Symbol: ECE2 EEF1AKMT4-ECE2 KIAA0604 UNQ403/PRO740
Gene ID: 110599583 9718
Organism: Homo sapiens (human)

External Links

GlyGen: P0DPD6
PubChem: P0DPD6
The Human Metabolome Database: HMDBP12657
Re-Glyco: P0DPD6

Annotation

Keyword: Alternative splicing Cytoplasmic vesicle Disulfide bond Glycoprotein Golgi apparatus Metal-binding Metalloprotease Methyltransferase Multifunctional enzyme Reference proteome Signal-anchor Transmembrane helix Zinc

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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2

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GO Term	Evidence Code	Reference
G protein-coupled receptor signaling pathway	TAS	Reactome
cell-cell signaling	TAS	PMID
protein processing	IBA	GO_REF
peptide hormone processing	IDA	PMID
peptide hormone processing	IEA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling

signal transduction [inference]

G protein-coupled receptor signaling pathway

metabolic process [inference]

methylation

hormone metabolic process [inference]

peptide hormone processing

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

peptide hormone processing

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GO Term	Evidence Code	Reference
Golgi membrane	ISS	GO_REF
Golgi membrane	IEA	GO_REF
plasma membrane	IBA	GO_REF
transport vesicle membrane	ISS	GO_REF
transport vesicle membrane	TAS	Reactome

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane

transport vesicle membrane

bounding membrane of organelle [inference]

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	Reference
metalloendopeptidase activity	EXP	PMID
metalloendopeptidase activity	TAS	Reactome
metalloendopeptidase activity	IDA	PMID
metalloendopeptidase activity	IBA	GO_REF
metalloendopeptidase activity	IEA	GO_REF GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring one-carbon groups [inference]

methyltransferase activity

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MASPGAGRAPPELPERNCGYREVEYWDQRYQGAADSAPYDWFGDFSSFRALLEPELRPEDRILVLGCGNSALSYELFLGGFPNVTSVDYSSVVVAAMQARHAHVPQLRWETMDVRKLDFPSASFDVVLEKGTLDALLAGERDPWTVSSEGVHTVDQVLSEVGFQKGTRQLLGSRTQLELVLAGASLLLAALLLGCLVALGVQYHRDPSHSTCLTEACIRVAGKILESLDRGVSPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAEQKTQRFYLSCLQVERIEELGAQPLRDLIEKIGGWNITGPWDQDNFMEVLKAVAGTYRATPFFTVYISADSKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGGRPTSTREQMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQALAPSMDWLEFLSFLLSPLELSDSEPVVVYGMDYLQQVSELINRTEPSILNNYLIWNLVQKTTSSLDRRFESAQEKLLETLYGTKKSCVPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMISEIRTAFEEALGQLVWMDEKTRQAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEISEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRNHTACMEEQYNQYQVNGERLNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 9** entries
Position	Description	Source
207	N-linked (GlcNAc...) asparagine	UniProt GlyGen
211	N-linked (GlcNAc...) asparagine	UniProt GlyGen
252	N-linked (GlcNAc...) asparagine	UniProt GlyGen
312	N-linked (GlcNAc...) asparagine	UniProt GlyGen
357	N-linked (GlcNAc...) asparagine	UniProt GlyGen
424	N-linked (GlcNAc...) asparagine	UniProt GlyGen
580	N-linked (GlcNAc...) asparagine	UniProt GlyGen
673	N-linked (GlcNAc...) asparagine	UniProt GlyGen
681	N-linked (GlcNAc...) asparagine	UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
Peptide ligand-binding receptors	Homo sapiens

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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External Links

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International Collaboration

Acknowledgements