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H-2 class II histocompatibility antigen gamma chain

Summary

UniProt ID

P10247

Gene Symbol

Cd74

Gene ID

25599

Organism

Rattus norvegicus (Norway rat)

External Links

PubChem: P10247
Re-Glyco: P10247

Annotation

Keyword

Adaptive immunity
Alternative splicing
Cell membrane
Chaperone
Disulfide bond
Endoplasmic reticulum
Endosome
Golgi apparatus
Lysosome
Phosphoprotein
Proteoglycan
Reference proteome
Secreted
Signal-anchor
Transmembrane helix

Gene Ontology (GO)

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GO Term
extracellular space
nucleus
cytoplasm
lysosome
vacuole
plasma membrane
membrane
protein-containing complex
MHC class II protein complex
late endosome

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 44 in total

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GO Term
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
positive regulation of cytokine-mediated signaling pathway
T cell activation involved in immune response
negative regulation of peptide secretion
positive regulation of type 2 immune response
intracellular protein transport
defense response
positive regulation of gene expression
immunoglobulin mediated immune response
antigen processing and presentation

Displaying **all 10** entries
GO Term
MHC class II protein complex binding
macrophage migration inhibitory factor binding
MHC class II protein binding, via antigen binding groove
amyloid-beta binding
cytokine receptor activity
cytokine binding
nitric-oxide synthase binding
CD4 receptor binding
MHC class II protein binding
protein folding chaperone

Annotation information from UniProt.

Sequence

MDDQRDLISNHEQLPILGQRARAPESNCNRGVLYTSVSVLVALLLAGQATTAYFLYQQQGRLDKLTVTSQNLQLENLRMKLPKSAKPVSPMRMATPLLMRPLSMDNMLQAPVKNVTKYGNMTQDHVMHLLTKSGPVNYPQLKGSFPENLKHLKNSMNGLDWKVFESWMKQWLLFEMSKNSLEEKQPTQTPPKVLTKCQEEVSHIPDVHPGAFRPKCDENGNYMPLQCHGSTGYCWCVFPNGTEVPHTKSRGRHNCSEPLDMEDPSSGLGVTKQDMGQMFL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites