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Lipoprotein lipase

Summary

UniProt ID: P11602
Gene Symbol: LPL
Gene ID: 396219
Organism: Gallus gallus (chicken)

External Links

GlyGen: P11602
PubChem: P11602
Re-Glyco: P11602

Annotation

Keyword: Calcium Cell membrane Chylomicron Disulfide bond Extracellular matrix Glycoprotein Heparin-binding Hydrolase Lipid degradation Metal-binding Nitration Reference proteome Signal VLDL

Gene Ontology (GO)

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	Reference
fatty acid metabolic process	ISS	GO_REF
fatty acid metabolic process	IEA	GO_REF
fatty acid biosynthetic process	IBA	GO_REF
fatty acid biosynthetic process	IEA	GO_REF
positive regulation of macrophage derived foam cell differentiation

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

lipoprotein particle mediated signaling [inference]

low-density lipoprotein particle mediated signaling

metabolic process [inference]

catabolic process [inference]

lipid catabolic process [inference]

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

fatty acid metabolic process

fatty acid biosynthetic process

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

acylglycerol catabolic process [inference]

triglyceride catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

lipid biosynthetic process [inference]

fatty acid biosynthetic process

lipid catabolic process [inference]

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

fatty acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-containing complex remodeling [inference]

protein-lipid complex remodeling [inference]

plasma lipoprotein particle remodeling [inference]

triglyceride-rich lipoprotein particle remodeling [inference]

high-density lipoprotein particle remodeling

protein-lipid complex organization [inference]

protein-lipid complex remodeling [inference]

plasma lipoprotein particle remodeling [inference]

triglyceride-rich lipoprotein particle remodeling [inference]

high-density lipoprotein particle remodeling

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle remodeling [inference]

triglyceride-rich lipoprotein particle remodeling [inference]

high-density lipoprotein particle remodeling

multicellular organismal process [inference]

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle remodeling [inference]

triglyceride-rich lipoprotein particle remodeling [inference]

high-density lipoprotein particle remodeling

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis [inference]

acylglycerol homeostasis [inference]

triglyceride homeostasis

sterol homeostasis [inference]

cholesterol homeostasis

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of lipid localization [inference]

positive regulation of lipid localization [inference]

positive regulation of lipid storage [inference]

positive regulation of cholesterol storage

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of lipid storage [inference]

positive regulation of cholesterol storage

positive regulation of cell differentiation [inference]

positive regulation of response to stimulus [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of adipose tissue development

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of adipose tissue development

positive regulation of lipid localization [inference]

positive regulation of lipid storage [inference]

positive regulation of cholesterol storage

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response

regulation of inflammatory response [inference]

positive regulation of inflammatory response

positive regulation of response to stimulus [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response

regulation of response to stress [inference]

regulation of defense response [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response

regulation of inflammatory response [inference]

positive regulation of inflammatory response

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of macrophage derived foam cell differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

positive regulation of cell differentiation [inference]

regulation of fat cell differentiation [inference]

positive regulation of fat cell differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of adipose tissue development

regulation of adipose tissue development [inference]

positive regulation of adipose tissue development

regulation of cellular process [inference]

signal transduction [inference]

lipoprotein particle mediated signaling [inference]

low-density lipoprotein particle mediated signaling

regulation of lipid storage [inference]

positive regulation of lipid storage [inference]

positive regulation of cholesterol storage

regulation of cholesterol storage [inference]

positive regulation of cholesterol storage

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

regulation of chemokine production [inference]

positive regulation of chemokine production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

regulation of chemokine production [inference]

positive regulation of chemokine production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

regulation of cell differentiation [inference]

regulation of macrophage derived foam cell differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

positive regulation of cell differentiation [inference]

regulation of fat cell differentiation [inference]

positive regulation of fat cell differentiation

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of lipid storage [inference]

positive regulation of cholesterol storage

positive regulation of cell differentiation [inference]

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

regulation of chemokine production [inference]

positive regulation of chemokine production

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of adipose tissue development

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GO Term	Evidence Code	Reference
obsolete extracellular space
plasma membrane	ISS	GO_REF
plasma membrane	IEA	GO_REF
very-low-density lipoprotein particle
chylomicron

GO Hierarchy

cellular component

protein-containing complex [inference]

protein-lipid complex [inference]

lipoprotein particle [inference]

plasma lipoprotein particle [inference]

triglyceride-rich plasma lipoprotein particle [inference]

very-low-density lipoprotein particle

chylomicron

extracellular protein-containing complex [inference]

plasma lipoprotein particle [inference]

triglyceride-rich plasma lipoprotein particle [inference]

very-low-density lipoprotein particle

chylomicron

catalytic complex

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	Reference
lipoprotein lipase activity	ISS	GO_REF
lipoprotein lipase activity	IBA	GO_REF
lipoprotein lipase activity	IEA	GO_REF GO_REF GO_REF GO_REF
triacylglycerol lipase activity	ISS	GO_REF
triacylglycerol lipase activity	IEA	GO_REF GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

lipase activity [inference]

triacylglycerol lipase activity

lipoprotein lipase activity

phospholipase activity [inference]

glycerophospholipase activity [inference]

A1-type glycerophospholipase activity [inference]

glycerophospholipid phospholipase A1 activity

carboxylic ester hydrolase activity [inference]

triacylglycerol lipase activity

lipoprotein lipase activity

A1-type glycerophospholipase activity [inference]

glycerophospholipid phospholipase A1 activity

binding [inference]

protein binding [inference]

identical protein binding [inference]

protein homodimerization activity

proteoglycan binding [inference]

heparan sulfate proteoglycan binding

protein dimerization activity [inference]

protein homodimerization activity

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

protein-containing complex binding [inference]

protein-lipid complex binding [inference]

lipoprotein particle binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

proteoglycan binding [inference]

heparan sulfate proteoglycan binding

sulfur compound binding [inference]

heparin binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MERGRGMGKTALLAVLCLCLRGAAGSDPEAEMNFEGIESKFSLRTPAEPDEDVCYLVPGQMDSLAQCNFNHTSKTFVVIHGWTVTGMYESWVPKLVDALYKREPDSNVIVVDWLVRAQQHYPVSAAYTKLVGKDVAMFIDWMEEKFNYPLNNVHLLGYSLGAHAAGIAGSLTKKKVNRITGLDPAGPTFEYADAPIRLSPDDADFVDVLHTYTRGSPDRSIGIQKPVGHIDIYPNGGGFQPGCNLGEALRLIAEKGFSDVDQLVKCSHERSIHLFIDSLLYEEKPSMAYRCNTKEAFEKGLCLSCRKNRCNNLGYKVNRVRTKRNTKMYLKTRAQMPYKVFHYQVKIHFFGKTNVTKVDQPFLISLYGTLDESENIPFTLPEVSSNKTFSFLIYTEVDIGDLLMLKLQWEKDTFFSWSDWWTPFAFTIQRVRVKSGETQKKVVFCSRDGSSRLGKGEEAAIFVKCLEQPVSRKRGGAKKASKENSAHESA

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	Description	PubMed ID	Source
70	N-linked (GlcNAc...) (complex) asparagine	1985932	UniProt GlyGen
354	N-linked (GlcNAc...) asparagine	1985932	UniProt GlyGen
386	N-linked (GlcNAc...) asparagine	1985932	UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
Assembly of active LPL and LIPC lipase complexes	Gallus gallus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Summary

External Links

Annotation

International Collaboration

Acknowledgements