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Properdin

Summary

UniProt ID: P11680
Gene Symbol: Cfp Pfc
Gene ID: 18636
Organism: Mus musculus (house mouse)

External Links

GlycoProtDB: GPDB0003355
Re-Glyco: P11680

Annotation

Keyword: Complement alternate pathway Disulfide bond Glycoprotein Reference proteome Repeat Secreted Signal

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	Reference
complement activation	NAS	PMID
complement activation, alternative pathway	IMP	PMID
positive regulation of complement activation, alternative pathway	ISO	GO_REF
positive regulation of complement activation, alternative pathway	IEA	GO_REF
positive regulation of immune response	NAS	PMID

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

complement activation

complement activation, alternative pathway

activation of immune response [inference]

complement activation

complement activation, alternative pathway

immune response [inference]

humoral immune response [inference]

complement activation

complement activation, alternative pathway

innate immune response [inference]

complement activation, alternative pathway

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

complement activation, alternative pathway

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

complement activation, alternative pathway

immune response [inference]

humoral immune response [inference]

complement activation

complement activation, alternative pathway

innate immune response [inference]

complement activation, alternative pathway

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

complement activation, alternative pathway

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

complement activation, alternative pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of complement activation [inference]

positive regulation of complement activation, alternative pathway

positive regulation of opsonization

positive regulation of immune response

activation of immune response [inference]

complement activation

complement activation, alternative pathway

positive regulation of humoral immune response [inference]

positive regulation of complement activation [inference]

positive regulation of complement activation, alternative pathway

positive regulation of innate immune response [inference]

positive regulation of complement activation, alternative pathway

regulation of immune effector process [inference]

positive regulation of immune effector process [inference]

positive regulation of complement activation [inference]

positive regulation of complement activation, alternative pathway

positive regulation of opsonization

regulation of complement activation [inference]

regulation of complement activation, alternative pathway [inference]

positive regulation of complement activation, alternative pathway

positive regulation of complement activation [inference]

positive regulation of complement activation, alternative pathway

regulation of opsonization [inference]

positive regulation of opsonization

regulation of immune response [inference]

regulation of humoral immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of complement activation [inference]

positive regulation of complement activation, alternative pathway

regulation of complement activation [inference]

regulation of complement activation, alternative pathway [inference]

positive regulation of complement activation, alternative pathway

positive regulation of complement activation [inference]

positive regulation of complement activation, alternative pathway

regulation of innate immune response [inference]

regulation of complement activation, alternative pathway [inference]

positive regulation of complement activation, alternative pathway

positive regulation of innate immune response [inference]

positive regulation of complement activation, alternative pathway

positive regulation of immune response

activation of immune response [inference]

complement activation

complement activation, alternative pathway

positive regulation of humoral immune response [inference]

positive regulation of complement activation [inference]

positive regulation of complement activation, alternative pathway

positive regulation of innate immune response [inference]

positive regulation of complement activation, alternative pathway

regulation of localization [inference]

regulation of transport [inference]

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of opsonization

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of opsonization

regulation of phagocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of opsonization

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of complement activation [inference]

positive regulation of complement activation, alternative pathway

positive regulation of opsonization

positive regulation of immune response

activation of immune response [inference]

complement activation

complement activation, alternative pathway

positive regulation of humoral immune response [inference]

positive regulation of complement activation [inference]

positive regulation of complement activation, alternative pathway

positive regulation of innate immune response [inference]

positive regulation of complement activation, alternative pathway

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of opsonization

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of complement activation, alternative pathway

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

positive regulation of complement activation, alternative pathway

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of complement activation, alternative pathway

positive regulation of immune response

activation of immune response [inference]

complement activation

complement activation, alternative pathway

positive regulation of humoral immune response [inference]

positive regulation of complement activation [inference]

positive regulation of complement activation, alternative pathway

positive regulation of innate immune response [inference]

positive regulation of complement activation, alternative pathway

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of opsonization

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of complement activation, alternative pathway

regulation of innate immune response [inference]

regulation of complement activation, alternative pathway [inference]

positive regulation of complement activation, alternative pathway

positive regulation of innate immune response [inference]

positive regulation of complement activation, alternative pathway

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of complement activation, alternative pathway

regulation of innate immune response [inference]

regulation of complement activation, alternative pathway [inference]

positive regulation of complement activation, alternative pathway

positive regulation of innate immune response [inference]

positive regulation of complement activation, alternative pathway

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of complement activation, alternative pathway

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

positive regulation of complement activation, alternative pathway

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of complement activation, alternative pathway

positive regulation of immune response

activation of immune response [inference]

complement activation

complement activation, alternative pathway

positive regulation of humoral immune response [inference]

positive regulation of complement activation [inference]

positive regulation of complement activation, alternative pathway

positive regulation of innate immune response [inference]

positive regulation of complement activation, alternative pathway

regulation of immune response [inference]

regulation of humoral immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of complement activation [inference]

positive regulation of complement activation, alternative pathway

regulation of complement activation [inference]

regulation of complement activation, alternative pathway [inference]

positive regulation of complement activation, alternative pathway

positive regulation of complement activation [inference]

positive regulation of complement activation, alternative pathway

regulation of innate immune response [inference]

regulation of complement activation, alternative pathway [inference]

positive regulation of complement activation, alternative pathway

positive regulation of innate immune response [inference]

positive regulation of complement activation, alternative pathway

positive regulation of immune response

activation of immune response [inference]

complement activation

complement activation, alternative pathway

positive regulation of humoral immune response [inference]

positive regulation of complement activation [inference]

positive regulation of complement activation, alternative pathway

positive regulation of innate immune response [inference]

positive regulation of complement activation, alternative pathway

regulation of response to stress [inference]

regulation of defense response [inference]

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

positive regulation of complement activation, alternative pathway

regulation of innate immune response [inference]

regulation of complement activation, alternative pathway [inference]

positive regulation of complement activation, alternative pathway

positive regulation of innate immune response [inference]

positive regulation of complement activation, alternative pathway

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of opsonization

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of opsonization

regulation of phagocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of opsonization

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of opsonization

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of opsonization

regulation of phagocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of opsonization

regulation of opsonization [inference]

positive regulation of opsonization

regulation of biological quality [inference]

regulation of protein stability [inference]

protein stabilization

Displaying **all 5** entries
GO Term	Evidence Code	Reference
obsolete extracellular space
secretory granule	IDA	PMID
cytoplasmic side of Golgi membrane	ISO	GO_REF
cytoplasmic side of Golgi membrane	NAS	PMID
cytoplasmic side of Golgi membrane	IEA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of Golgi membrane

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MPAEMQAPQWLLLLLVILPATGSDPVLCFTQYEESSGRCKGLLGRDIRVEDCCLNAAYAFQEHDGGLCQACRSPQWSAWSLWGPCSVTCSEGSQLRHRRCVGRGGQCSENVAPGTLEWQLQACEDQPCCPEMGGWSEWGPWGPCSVTCSKGTQIRQRVCDNPAPKCGGHCPGEAQQSQACDTQKTCPTHGAWASWGPWSPCSGSCLGGAQEPKETRSRSCSAPAPSHQPPGKPCSGPAYEHKACSGLPPCPVAGGWGPWSPLSPCSVTCGLGQTLEQRTCDHPAPRHGGPFCAGDATRNQMCNKAVPCPVNGEWEAWGKWSDCSRLRMSINCEGTPGQQSRSRSCGGRKFNGKPCAGKLQDIRHCYNIHNCIMKGSWSQWSTWSLCTPPCSPNATRVRQRLCTPLLPKYPPTVSMVEGQGEKNVTFWGTPRPLCEALQGQKLVVEEKRSCLHVPVCKDPEEKKP

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **1 - 10** of 19 in total

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Position	Description	Source
79	C-linked (Man) tryptophan	UniProt
82	C-linked (Man) tryptophan	UniProt
135	C-linked (Man) tryptophan	UniProt
138	C-linked (Man) tryptophan	UniProt
141	C-linked (Man) tryptophan	UniProt
147	O-linked (Fuc...) threonine	UniProt
192	C-linked (Man) tryptophan	UniProt
195	C-linked (Man) tryptophan	UniProt
198	C-linked (Man) tryptophan	UniProt
204	O-linked (Fuc...) serine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 5** entries
Pathway Name	Organism
Activation of C3 and C5	Mus musculus
Alternative complement activation	Mus musculus
Neutrophil degranulation	Mus musculus
O-glycosylation of TSR domain-containing proteins	Mus musculus
Regulation of Complement cascade	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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