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Calcium/calmodulin-dependent protein kinase type II subunit alpha

Summary

UniProt ID: P11798
Gene Symbol: Camk2a
Gene ID: 12322
Organism: Mus musculus (house mouse)

External Links

GlyGen: P11798
PubChem: P11798
The O-GlcNAc Database: P11798
O-GlcNAcAtlas: P11798
Re-Glyco: P11798

Annotation

Keyword: 3D-structure ATP-binding Alternative splicing Calmodulin-binding Cell projection Cytoplasm Direct protein sequencing Magnesium Metal-binding Palmitate Phosphoprotein Reference proteome Serine/threonine-protein kinase Synapse

Gene Ontology (GO)

Displaying entries **1 - 5** of 40 in total

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GO Term	Evidence Code	Reference
G1/S transition of mitotic cell cycle	IMP	PMID
G1/S transition of mitotic cell cycle	IEA	GO_REF
response to ischemia	IMP	PMID
calcium ion transport	IMP	PMID
calcium ion transport	IEA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

cell surface receptor signaling pathway via STAT [inference]

cell surface receptor signaling pathway via JAK-STAT

G protein-coupled receptor signaling pathway [inference]

angiotensin-activated signaling pathway

ligand-gated ion channel signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation [inference]

peptidyl-threonine phosphorylation [inference]

peptidyl-threonine autophosphorylation

protein autophosphorylation [inference]

peptidyl-threonine autophosphorylation

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

peptidyl-threonine phosphorylation [inference]

peptidyl-threonine autophosphorylation

protein autophosphorylation [inference]

peptidyl-threonine autophosphorylation

peptidyl-amino acid modification [inference]

peptidyl-threonine modification [inference]

peptidyl-threonine phosphorylation [inference]

peptidyl-threonine autophosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation [inference]

peptidyl-threonine phosphorylation [inference]

peptidyl-threonine autophosphorylation

protein autophosphorylation [inference]

peptidyl-threonine autophosphorylation

peptidyl-amino acid modification [inference]

peptidyl-threonine modification [inference]

peptidyl-threonine phosphorylation [inference]

peptidyl-threonine autophosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

peptidyl-threonine phosphorylation [inference]

peptidyl-threonine autophosphorylation

protein autophosphorylation [inference]

peptidyl-threonine autophosphorylation

peptidyl-amino acid modification [inference]

peptidyl-threonine modification [inference]

peptidyl-threonine phosphorylation [inference]

peptidyl-threonine autophosphorylation

vesicle-mediated transport [inference]

vesicle-mediated transport to the plasma membrane [inference]

neurotransmitter receptor transport to plasma membrane

cell cycle process [inference]

cell cycle phase transition [inference]

mitotic cell cycle phase transition [inference]

G1/S transition of mitotic cell cycle

cell cycle G1/S phase transition [inference]

G1/S transition of mitotic cell cycle

mitotic cell cycle process [inference]

mitotic cell cycle phase transition [inference]

G1/S transition of mitotic cell cycle

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

neurotransmitter receptor transport to plasma membrane

establishment of protein localization to membrane [inference]

neurotransmitter receptor transport to plasma membrane

vesicle-mediated transport to the plasma membrane [inference]

neurotransmitter receptor transport to plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization [inference]

apoptotic mitochondrial changes [inference]

regulation of mitochondrial membrane permeability involved in apoptotic process

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

dendrite morphogenesis

developmental process [inference]

anatomical structure morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

dendrite morphogenesis

anatomical structure development [inference]

dendritic spine development

response to stimulus [inference]

response to stress [inference]

response to ischemia

response to chemical [inference]

response to peptide [inference]

response to cytokine [inference]

response to type II interferon [inference]

cellular response to type II interferon

response to interferon-beta [inference]

cellular response to interferon-beta

cellular response to cytokine stimulus [inference]

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein transport [inference]

neurotransmitter receptor transport [inference]

neurotransmitter receptor transport to plasma membrane

protein localization to membrane [inference]

neurotransmitter receptor transport to plasma membrane

protein localization to cell periphery [inference]

neurotransmitter receptor transport to plasma membrane

protein-containing complex localization [inference]

neurotransmitter receptor transport [inference]

neurotransmitter receptor transport to plasma membrane

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport

protein transport [inference]

neurotransmitter receptor transport [inference]

neurotransmitter receptor transport to plasma membrane

vesicle-mediated transport [inference]

vesicle-mediated transport to the plasma membrane [inference]

neurotransmitter receptor transport to plasma membrane

establishment of protein localization [inference]

protein transport [inference]

neurotransmitter receptor transport [inference]

neurotransmitter receptor transport to plasma membrane

establishment of protein localization to membrane [inference]

neurotransmitter receptor transport to plasma membrane

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

neurotransmitter receptor transport to plasma membrane

establishment of protein localization to membrane [inference]

neurotransmitter receptor transport to plasma membrane

vesicle-mediated transport to the plasma membrane [inference]

neurotransmitter receptor transport to plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

regulation of endocannabinoid signaling pathway

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

regulation of receptor signaling pathway via STAT [inference]

regulation of receptor signaling pathway via JAK-STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of neurotransmitter secretion

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity

regulation of localization [inference]

regulation of protein localization [inference]

regulation of protein localization to synapse [inference]

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

regulation of protein localization to cell periphery [inference]

regulation of protein localization to membrane [inference]

regulation of transport [inference]

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of calcium ion transport [inference]

positive regulation of calcium ion transport

positive regulation of monoatomic ion transport [inference]

positive regulation of calcium ion transport

regulation of secretion [inference]

regulation of secretion by cell [inference]

regulation of neurotransmitter secretion

positive regulation of transport [inference]

positive regulation of monoatomic ion transport [inference]

positive regulation of calcium ion transport

regulation of neurotransmitter transport [inference]

regulation of neurotransmitter secretion

regulation of cellular localization [inference]

regulation of protein localization to membrane [inference]

regulation of receptor localization to synapse [inference]

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

regulation of locomotion [inference]

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of neuron migration

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of muscle cell apoptotic process [inference]

positive regulation of striated muscle cell apoptotic process [inference]

positive regulation of cardiac muscle cell apoptotic process

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of transport [inference]

positive regulation of monoatomic ion transport [inference]

positive regulation of calcium ion transport

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of ferroptosis

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

regulation of endocannabinoid signaling pathway

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

regulation of receptor signaling pathway via STAT [inference]

regulation of receptor signaling pathway via JAK-STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

cell surface receptor signaling pathway via STAT [inference]

cell surface receptor signaling pathway via JAK-STAT

G protein-coupled receptor signaling pathway [inference]

angiotensin-activated signaling pathway

ligand-gated ion channel signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

regulation of endocannabinoid signaling pathway

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

regulation of receptor signaling pathway via STAT [inference]

regulation of receptor signaling pathway via JAK-STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of neurotransmitter secretion

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

regulation of muscle cell apoptotic process [inference]

positive regulation of muscle cell apoptotic process [inference]

positive regulation of striated muscle cell apoptotic process [inference]

positive regulation of cardiac muscle cell apoptotic process

regulation of striated muscle cell apoptotic process [inference]

positive regulation of striated muscle cell apoptotic process [inference]

positive regulation of cardiac muscle cell apoptotic process

regulation of cardiac muscle cell apoptotic process [inference]

positive regulation of cardiac muscle cell apoptotic process

positive regulation of apoptotic process [inference]

positive regulation of muscle cell apoptotic process [inference]

positive regulation of striated muscle cell apoptotic process [inference]

positive regulation of cardiac muscle cell apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of muscle cell apoptotic process [inference]

positive regulation of striated muscle cell apoptotic process [inference]

positive regulation of cardiac muscle cell apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of ferroptosis

regulation of ferroptosis [inference]

negative regulation of ferroptosis

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of muscle cell apoptotic process [inference]

positive regulation of striated muscle cell apoptotic process [inference]

positive regulation of cardiac muscle cell apoptotic process

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of ferroptosis

regulation of cellular localization [inference]

regulation of protein localization to membrane [inference]

regulation of secretion by cell [inference]

regulation of neurotransmitter secretion

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of neuron migration

regulation of biological quality [inference]

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity

regulation of membrane permeability [inference]

regulation of mitochondrial membrane permeability [inference]

regulation of mitochondrial membrane permeability involved in apoptotic process

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity

regulation of hydrolase activity [inference]

negative regulation of hydrolase activity

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GO Term	Evidence Code	Reference
cytoplasm	IBA	GO_REF
cytoplasm	IEA	GO_REF
mitochondrion	IDA	PMID
calcium- and calmodulin-dependent protein kinase complex	ISS	GO_REF
calcium- and calmodulin-dependent protein kinase complex	ISO	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

intracellular protein-containing complex [inference]

calcium- and calmodulin-dependent protein kinase complex

catalytic complex [inference]

calcium- and calmodulin-dependent protein kinase complex

cellular anatomical structure [inference]

cytoplasm

neuron projection cytoplasm [inference]

dendrite cytoplasm

cytosol [inference]

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

neuron spine [inference]

dendritic spine

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

postsynaptic specialization [inference]

postsynaptic density

cell body [inference]

neuronal cell body

postsynapse [inference]

dendritic spine

Displaying entries **1 - 5** of 24 in total

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GO Term	Evidence Code	Reference
protein serine/threonine kinase activity	ISO	GO_REF
protein serine/threonine kinase activity	IDA	PMID
protein serine/threonine kinase activity	IMP	PMID PMID PMID PMID
protein serine/threonine kinase activity	IEA	GO_REF
calcium/calmodulin-dependent protein kinase activity	ISO	GO_REF GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity

protein kinase activity [inference]

protein serine/threonine kinase activity

calcium/calmodulin-dependent protein kinase activity

protein serine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

calcium/calmodulin-dependent protein kinase activity

protein serine kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

calcium/calmodulin-dependent protein kinase activity

protein serine kinase activity

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

glutamate receptor binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MATITCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSGGKSGGNKKNDGVKESSESTNTTIEDEDTKVRKQEIIKVTEQLIEAISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIHLMGDESACIAYIRITQYLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAPSVLPH

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 5** entries
Position	PubMed ID	GlyTouCan ID	Source
176			GlyGen
253		G49108TO	GlyGen
305	22645316 24052497 32134364 33300544 35822049 40684658 40885482	G49108TO	GlyGen The O-GlcNAc Database
306		G49108TO	GlyGen
335		G63276XU	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 9** entries
Pathway Name	Organism
Ca2+ pathway	Mus musculus
HSF1-dependent transactivation	Mus musculus
Interferon gamma signaling	Mus musculus
Ion homeostasis	Mus musculus
Ion transport by P-type ATPases	Mus musculus
RAF activation	Mus musculus
RAF/MAP kinase cascade	Mus musculus
Trafficking of AMPA receptors	Mus musculus
Unblocking of NMDA receptors, glutamate binding and activation	Mus musculus

Disease

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:3312	bipolar disorder	Alliance of Genome Resources
DOID:0060041	autism spectrum disorder	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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External Links

Annotation

International Collaboration

Acknowledgements