Amyloid-beta precursor protein

Summary
UniProt ID
P12023
Gene Symbol
  • App
  • A4
  • AD1
Organism
Mus musculus (house mouse)
External Links
GlycoProtDB
GPDB0003366
GlyGen
P12023
PubChem
P12023
The O-GlcNAc Database
P12023
RaftProt
P12023
O-GlcNAcAtlas
P12023
Annotation
Keyword
  • 3D-structure
  • Alternative splicing
  • Amyloid
  • Apoptosis
  • Cell adhesion
  • Cell membrane
  • Cell projection
  • Coated pit
  • Copper
  • Cytoplasm
  • Cytoplasmic vesicle
  • Disulfide bond
  • Endocytosis
  • Endoplasmic reticulum
  • Endosome
  • Glycoprotein
  • Golgi apparatus
  • Heparin-binding
  • Iron
  • Isopeptide bond
  • Metal-binding
  • Notch signaling pathway
  • Nucleus
  • Phosphoprotein
  • Reference proteome
  • Secreted
  • Serine protease inhibitor
  • Signal
  • Sulfation
  • Transmembrane helix
  • Ubl conjugation
  • Zinc
Gene Ontology (GO)
Sequence
MLPSLALLLLAAWTVRALEVPTDGNAGLLAEPQIAMFCGKLNMHMNVQNGKWESDPSGTKTCIGTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHTHIVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDSVDSADAEEDDSDVWWGGADTDYADGGEDKVVEVAEEEEVADVEEEEADDDEDVEDGDEVEEEAEEPYEEATERTTSTATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCVPFFYGGCGGNRNNFDTEEYCMAVCGSVSTQSLLKTTSEPLPQDPDKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPHHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHPFGVDSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFGHDSGFEVRHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
Glycosylation Sites
Displaying all 5 entries
Position Description PubMed ID GlyTouCan ID Source
542 N-linked (GlcNAc...) asparagine
571 N-linked (GlcNAc...) asparagine
651
652
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying entries 11 - 12 of 12 in total
Pathway Name Organism
TAK1-dependent IKK and NF-kappa-B activation Mus musculus
TRAF6 mediated NF-kB activation Mus musculus

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 19, 2024