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Collagen alpha-1(XI) chain

Summary

UniProt ID: P12107
Gene Symbol: COL11A1 COLL6
Gene ID: 1301
Organism: Homo sapiens (human)

External Links

GlyConnect

Collagen alpha-1(XI) chain

GlyGen

P12107

PubChem

P12107

The O-GlcNAc Database

P12107

RaftProt

P12107

O-GlcNAcAtlas

P12107

Re-Glyco

P12107

Annotation

Keyword: Alternative splicing Calcium Cataract Collagen Direct protein sequencing Disease variant Disulfide bond Dwarfism Ectodermal dysplasia Extracellular matrix Glycoprotein Hydroxylation Metal-binding Non-syndromic deafness Proteomics identification Reference proteome Repeat Signal Stickler syndrome

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	Reference
cartilage condensation
chondrocyte development
proteoglycan metabolic process
visual perception	IMP	PMID PMID
sensory perception of sound	IMP	PMID

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process

primary metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process

cellular developmental process [inference]

cell differentiation [inference]

endodermal cell differentiation

cell development [inference]

chondrocyte development

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

cell aggregation [inference]

cartilage condensation

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of light stimulus [inference]

visual perception

sensory perception of mechanical stimulus [inference]

sensory perception of sound

detection of mechanical stimulus involved in sensory perception of sound

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

embryonic organ morphogenesis [inference]

embryonic skeletal system morphogenesis

skeletal system morphogenesis [inference]

embryonic skeletal system morphogenesis

embryonic morphogenesis [inference]

inner ear morphogenesis

embryonic organ morphogenesis [inference]

embryonic skeletal system morphogenesis

tissue morphogenesis [inference]

muscle tissue morphogenesis [inference]

cardiac muscle tissue morphogenesis [inference]

ventricular cardiac muscle tissue morphogenesis

anatomical structure development [inference]

cell development [inference]

chondrocyte development

animal gross anatomical part developmental process [inference]

tissue development [inference]

connective tissue development [inference]

tendon development

cellular developmental process [inference]

cell differentiation [inference]

endodermal cell differentiation

cell development [inference]

chondrocyte development

response to stimulus [inference]

response to external stimulus [inference]

detection of external stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of sound

response to mechanical stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of sound

response to abiotic stimulus [inference]

detection of abiotic stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of sound

response to mechanical stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of sound

detection of stimulus [inference]

detection of external stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of sound

detection of abiotic stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of sound

detection of stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of sound

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	Reference
extracellular region	TAS	Reactome Reactome Reactome Reactome Reactome Reactome Reactome
collagen type II trimer
collagen type XI trimer	NAS	PMID PMID
collagen type XI trimer	IDA	PMID
collagen type XI trimer	IEA	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

collagen trimer [inference]

fibrillar collagen trimer [inference]

extracellular protein-containing complex [inference]

fibrillar collagen trimer [inference]

cellular anatomical structure [inference]

extracellular region

external encapsulating structure [inference]

extracellular matrix

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	Reference
extracellular matrix structural constituent	NAS	PMID
extracellular matrix structural constituent	IEA	GO_REF
extracellular matrix structural constituent conferring tensile strength	RCA	PMID PMID
extracellular matrix structural constituent conferring tensile strength	IBA	GO_REF
protein-macromolecule adaptor activity	NAS	PMID

GO Hierarchy

molecular function

structural molecule activity [inference]

extracellular matrix structural constituent

extracellular matrix structural constituent conferring tensile strength

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

extracellular matrix binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MEPWSSRWKTKRWLWDFTVTTLALTFLFQAREVRGAAPVDVLKALDFHNSPEGISKTTGFCTNRKNSKGSDTAYRVSKQAQLSAPTKQLFPGGTFPEDFSILFTVKPKKGIQSFLLSIYNEHGIQQIGVEVGRSPVFLFEDHTGKPAPEDYPLFRTVNIADGKWHRVAISVEKKTVTMIVDCKKKTTKPLDRSERAIVDTNGITVFGTRILDEEVFEGDIQQFLITGDPKAAYDYCEHYSPDCDSSAPKAAQAQEPQIDEYAPEDIIEYDYEYGEAEYKEAESVTEGPTVTEETIAQTEANIVDDFQEYNYGTMESYQTEAPRHVSGTNEPNPVEEIFTEEYLTGEDYDSQRKNSEDTLYENKEIDGRDSDLLVDGDLGEYDFYEYKEYEDKPTSPPNEEFGPGVPAETDITETSINGHGAYGEKGQKGEPAVVEPGMLVEGPPGPAGPAGIMGPPGLQGPTGPPGDPGDRGPPGRPGLPGADGLPGPPGTMLMLPFRYGGDGSKGPTISAQEAQAQAILQQARIALRGPPGPMGLTGRPGPVGGPGSSGAKGESGDPGPQGPRGVQGPPGPTGKPGKRGRPGADGGRGMPGEPGAKGDRGFDGLPGLPGDKGHRGERGPQGPPGPPGDDGMRGEDGEIGPRGLPGEAGPRGLLGPRGTPGAPGQPGMAGVDGPPGPKGNMGPQGEPGPPGQQGNPGPQGLPGPQGPIGPPGEKGPQGKPGLAGLPGADGPPGHPGKEGQSGEKGALGPPGPQGPIGYPGPRGVKGADGVRGLKGSKGEKGEDGFPGFKGDMGLKGDRGEVGQIGPRGEDGPEGPKGRAGPTGDPGPSGQAGEKGKLGVPGLPGYPGRQGPKGSTGFPGFPGANGEKGARGVAGKPGPRGQRGPTGPRGSRGARGPTGKPGPKGTSGGDGPPGPPGERGPQGPQGPVGFPGPKGPPGPPGKDGLPGHPGQRGETGFQGKTGPPGPGGVVGPQGPTGETGPIGERGHPGPPGPPGEQGLPGAAGKEGAKGDPGPQGISGKDGPAGLRGFPGERGLPGAQGAPGLKGGEGPQGPPGPVGSPGERGSAGTAGPIGLPGRPGPQGPPGPAGEKGAPGEKGPQGPAGRDGVQGPVGLPGPAGPAGSPGEDGDKGEIGEPGQKGSKGDKGENGPPGPPGLQGPVGAPGIAGGDGEPGPRGQQGMFGQKGDEGARGFPGPPGPIGLQGLPGPPGEKGENGDVGPMGPPGPPGPRGPQGPNGADGPQGPPGSVGSVGGVGEKGEPGEAGNPGPPGEAGVGGPKGERGEKGEAGPPGAAGPPGAKGPPGDDGPKGNPGPVGFPGDPGPPGEPGPAGQDGVGGDKGEDGDPGQPGPPGPSGEAGPPGPPGKRGPPGAAGAEGRQGEKGAKGEAGAEGPPGKTGPVGPQGPAGKPGPEGLRGIPGPVGEQGLPGAAGQDGPPGPMGPPGLPGLKGDPGSKGEKGHPGLIGLIGPPGEQGEKGDRGLPGTQGSPGAKGDGGIPGPAGPLGPPGPPGLPGPQGPKGNKGSTGPAGQKGDSGLPGPPGSPGPPGEVIQPLPILSSKKTRRHTEGMQADADDNILDYSDGMEEIFGSLNSLKQDIEHMKFPMGTQTNPARTCKDLQLSHPDFPDGEYWIDPNQGCSGDSFKVYCNFTSGGETCIYPDKKSEGVRISSWPKEKPGSWFSEFKRGKLLSYLDVEGNSINMVQMTFLKLLTASARQNFTYHCHQSAAWYDVSSGSYDKALRFLGSNDEEMSYDNNPFIKTLYDGCASRKGYEKTVIEINTPKIDQVPIVDVMINDFGDQNQKFGFEVGPVCFLG

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 10** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
72		30620550 38253038	G49108TO	GlyGen The O-GlcNAc Database
289				GlyGen
462		30620550 38253038	G49108TO	The O-GlcNAc Database
508		30459171	G43417UB	GlyGen
659		30620550 38253038	G49108TO	GlyGen The O-GlcNAc Database
741			G49108TO	GlyGen
822				GlyGen
1058		30620550 38253038	G49108TO	The O-GlcNAc Database
1478		30620550 38253038	G49108TO	The O-GlcNAc Database
1640	N-linked (GlcNAc...) asparagine	29741879 37074911	G39188ZX G41247ZX	UniProt GlyGen GlyConnect

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 7** entries
Pathway Name	Organism
Assembly of collagen fibrils and other multimeric structures	Homo sapiens
Collagen biosynthesis and modifying enzymes	Homo sapiens
Collagen chain trimerization	Homo sapiens
Collagen degradation	Homo sapiens
Developmental Lineage of Pancreatic Ductal Cells	Homo sapiens
MET activates PTK2 signaling	Homo sapiens
Non-integrin membrane-ECM interactions	Homo sapiens

Disease

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0070601	autosomal dominant nonsyndromic deafness 37	Alliance of Genome Resources
DOID:0111510	Marshall syndrome	Alliance of Genome Resources
DOID:0080672	fibrochondrogenesis 1	Alliance of Genome Resources
DOID:0080675	Stickler syndrome 2	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements